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A nucleic acid aptamer-modified molybdenum disulfide nanosheet photothermal agent with targeted recognition

A nucleic acid aptamer, molybdenum disulfide technology, applied in the direction of molybdenum sulfide, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of photothermal material retention, poor biocompatibility, poisoning, etc. problem, to achieve the effect of low cost, low toxicity and high metabolic rate

Active Publication Date: 2022-05-31
CHANGCHUN UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

Carbon materials such as carbon nanotubes and graphene have good photothermal conversion efficiency, but the strong hydrophobicity of most carbon materials makes their biocompatibility poor. Poisoning hazard

Method used

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  • A nucleic acid aptamer-modified molybdenum disulfide nanosheet photothermal agent with targeted recognition
  • A nucleic acid aptamer-modified molybdenum disulfide nanosheet photothermal agent with targeted recognition
  • A nucleic acid aptamer-modified molybdenum disulfide nanosheet photothermal agent with targeted recognition

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Experimental program
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Effect test

Embodiment 1

Embodiment 2

Embodiment 3

MoS2‑BSA nanosheets are similar in long strips, and their longitudinal size is smaller, indicating that aptamers reduce BSA aggregation, and MoS2‑

MoS2 in BSA‑Apt nanosheets is about 10 nm in size. The size of MoS2 in MoS2‑BSA Na flakes and MoS2‑BSA‑Apt Na Na flakes is compared

Uniform, about 10 nm.

[0083] MoS2, MoS2-BSA and MoS2-BSA-Apt nanosheet X-ray diffraction (XRD) as shown in Figure 9. It can be seen that three

The main diffraction peaks of the molybdenum disulfide nanosheets are at 40o and 58o, in addition, there is a small bulge near 43o. and

[0085] The results of the solution suspension stability test are shown in Figure 11(a)-(d). Compared with MoS2‑BSA nanosheets, MoS2 nanosheets

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Abstract

The invention discloses a nucleic acid aptamer-modified molybdenum disulfide nanosheet photothermal agent with targeted recognition. The invention constructs a targeted molybdenum disulfide nanosheet photothermal therapy system, which is characterized in that: The size diameter range of the functionalized molybdenum disulfide nanosheet MoS2-BSA-Apt is 80-120nm, and the size of MoS2 in the functionalized molybdenum disulfide nanosheet is 10nm; the functionalized molybdenum disulfide nanosheet is infrared Excellent photothermal effect under light irradiation; the functionalized molybdenum disulfide nanosheet has the ability to specifically recognize tumor cells, can be enriched around tumor cells and moved into target cells, and the nucleic acid aptamer modification of the present invention Molybdenum disulfide nanosheet photothermal agent has excellent biocompatibility, stability, high photothermal conversion efficiency, simple synthesis, low cost, low toxicity, high metabolic rate, targeting and can accurately and efficiently treat tumors Excellent photothermal therapy material.

Description

A nucleic acid aptamer-modified molybdenum disulfide nanosheet photothermal agent with targeted recognition technical field The present invention relates to a kind of nano-sheet photothermal agent with targeted recognition, specifically a kind of nucleic acid with targeted recognition Aptamer-modified molybdenum disulfide nanosheet photothermal agent. Background technique Cancer is a fatal disease that seriously threatens human health and life, and is a major public health problem for the current society. one of the problems. So far, more than 100 cancers have been discovered one after another, and the development and progress of different cancers have been clinically targeted. Appropriate treatment will be taken. The clinical treatment of cancer mainly includes chemotherapy, radiotherapy and surgery. Chemotherapy and radiotherapy In the problem of non-selective damage to normal tissues of the body, while eliminating tumor cells, it will also bring greater side ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/54A61P35/00B82Y30/00B82Y40/00C01G39/06
CPCA61K41/0052A61K47/549A61K41/0057A61P35/00C01G39/06B82Y30/00B82Y40/00C01P2004/64C01P2002/84C01P2004/04C01P2002/72C01P2002/82
Inventor 金丽虹申炳俊高芳芳陈甲琦逄博杨惠茹
Owner CHANGCHUN UNIV OF SCI & TECH
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