Small-size transcatheter artificial heart valve and preparation method thereof

An artificial heart valve, small-sized technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of increasing the size of the delivery, increasing the hardness of the valve, increasing the elastic modulus, etc. Effect of reduction and small conveying size

Pending Publication Date: 2020-09-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thinner tissue is less resistant to tension and prone to early tearing of the valve, too thick tissue increases delivery size, making it difficult to implant at the target site and possible complications during delivery, and less flexible
And thicker tissue can cause excessive compression during loading, which can cause damage to the valve tissue
[0004] In the prior art, the size of the valve is reduced by applying a compressive force during the cross-linking process. A disadvantage of this method is that the substrate is in close contact with the tissue, making it difficult for the cross-linking solvent to penetrate into the stressed tissue. If the bottom is made into a liquid-permeable structure, it is difficult to ensure the flatness of the tissue surface, resulting in a rough structure on the tissue surface, which is unfavorable for the hemodynamics of the valve.
Moreover, when the method compresses the thickness of the valve leaflet, due to the significant increase in the cross-linking density, it often leads to an increase in the elastic modulus, resulting in an increase in the hardness of the valve, and an increase in the stress received by the collagen fibers during bending. It is easy to cause the decline of mechanical properties and shorten the life of the valve
[0005] In the prior art, the thickness of the valve is also reduced by removing tissue surface material, but this method is easy to cause damage to the valve tissue, and this method will cause a decrease in mechanical properties due to the removal of a part of the tissue

Method used

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  • Small-size transcatheter artificial heart valve and preparation method thereof
  • Small-size transcatheter artificial heart valve and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preferred embodiment of the present invention provides a method for preparing a small-sized transcatheter artificial heart valve, and the specific steps are as follows:

[0038] Take fresh porcine pericardium, spread and fix it on a plastic plate, and dry it naturally. After 3 hours of drying, the film becomes transparent, and its thickness is less than 30% of the initial thickness. Then it is placed in glycerin solution for 3 weeks, and then placed In sterile normal saline for 1 week, its thickness increased, but less than the initial thickness, and then cross-linked using 0.625 wt% glutaraldehyde aqueous solution containing 25 wt% glycerin, the cross-linking time was 1 week, and the cross-linking was completed Afterwards, the valve was placed in glycerol solution for 3 weeks, and the leaflet tissue was obtained, the thickness of which was reduced by more than 25% compared with that of the pericardial tissue directly subjected to cross-linking treatment, and the mecha...

Embodiment 2

[0040] A preferred embodiment of the present invention provides a method for preparing a small-sized transcatheter artificial heart valve, and the specific steps are as follows:

[0041]Take fresh porcine pericardium, spread and fix it in the middle of a plastic plate, and freeze-dry it. After drying for 6 hours, its thickness is less than 20% of the original thickness, and then put it in glycerol solution for 3 weeks, and then put it in sterile normal saline 1 week, the thickness increased, but less than the initial thickness, then cross-linked using 0.625 wt% glutaraldehyde aqueous solution containing 25 wt% glycerin, the cross-linking time was 1 week, after the cross-linking was completed, the valve was placed in glycerin After 3 weeks in the solution, the valve leaflet tissue was obtained, the thickness of which was reduced by more than 30% compared with that of the pericardial tissue directly subjected to cross-linking treatment, and the mechanical properties and elastic m...

Embodiment 3

[0043] A preferred embodiment of the present invention provides a method for preparing a small-sized transcatheter artificial heart valve, and the specific steps are as follows:

[0044] Take fresh bovine pericardium, spread and fix in the middle of a plastic plate, freeze-dry, after drying for 6 hours, its thickness is less than 10% of the original thickness, then put it in glycerol solution for 3 weeks, then put it in sterile normal saline 1 week, the thickness increased, but less than the initial thickness, then cross-linked using 0.625 wt% glutaraldehyde aqueous solution containing 25 wt% glycerin, the cross-linking time was 1 week, after the cross-linking was completed, the valve was placed in glycerin After 3 weeks in the solution, the leaflet tissue was obtained, the thickness of which was reduced by more than 50% relative to the thickness of the pericardial tissue directly subjected to cross-linking treatment, and the mechanical properties and elastic modulus had no sig...

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PUM

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Abstract

The invention discloses a small-size transcatheter artificial heart valve and a preparation method thereof, and belongs to the technical field of medical equipment. The valve prepared by the method has a smaller delivery size than a valve prepared by an existing method, so that the implantation of the valve is facilitated, and complications in the delivery process are reduced. By the method of theinvention, a raw material can be cut and attached to a frame tissue in a certain geometrical shape after the size of the raw material is reduced, and therefore the implantable artificial heart valveis prepared. The implantable artificial heart valve is installed into a catheter delivery system before an operation, and the artificial heart valve can reach a designated part through a blood vesselthrough the delivery system to complete the replacement of the valve.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a small-sized transcatheter artificial heart valve and a preparation method thereof. Background technique [0002] Prosthetic heart valves are used to replace damaged or diseased heart valves. Where heart valve replacement is required, the dysfunctional valve is usually replaced with a mechanical or biological valve. Bioprosthetic valves are usually superior to mechanical valves because they usually do not require long-term anticoagulant therapy, especially currently bioprosthetic valves can be implanted through the catheter, which greatly reduces the risk of surgery and shortens the patient's recovery period. The most common transcatheter bioprosthetic valve is composed of bovine or porcine pericardium. After cross-linking, the pericardium is connected to a collapsible frame structure, which can be compressed on the delivery system for transcatheter implan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50
CPCA61L27/3625A61L27/3687A61L27/3691A61L27/50A61L2430/20A61L2430/40
Inventor 王云兵郭高阳
Owner SICHUAN UNIV
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