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Lutein ester and water-soluble lutein ester microcapsule, and preparation methods thereof

A technology of lutein ester and microcapsule, which is applied in the directions of microcapsule, capsule delivery, pharmaceutical formulation, etc., can solve the problem of high cost, and achieve the effects of low equipment requirements, easy storage, and high cost solution.

Inactive Publication Date: 2020-09-29
HENAN ZHONGDA HENGYUAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to overcome the high cost of large-scale production of different specifications of lutein ester microcapsule powder, the embodiment of the present application provides a method for extracting lutein ester and preparing lutein ester microcapsules. Method Firstly, extract lutein esters from marigold granules, and then prepare lutein ester microcapsules through a series of methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 100g of marigold flower granules, put them into a 2L round bottom flask, add 1.5L of ethyl acetate, stir in a water bath at 85°C, keep warm and reflux, mix ethyl acetate and marigold flower granules to extract lutein esters and other fat-soluble substances, until reflux The ethyl acetate becomes colorless, which means the extraction is complete. The ethyl acetate is recovered to obtain the crude extract of lutein ester. The crude extract is washed with a mixture of ethylene glycol: propylene glycol = 1:1 for 3 times, and the detergent is recovered by vacuum heating. , adding a small amount of antioxidants and mixing to obtain lutein esters with a content of 48%.

Embodiment 2

[0038]Weigh 100g of marigold flower granules, put them into a 2L round bottom flask, add 1.5L of n-hexane, stir in a water bath at 80°C, keep warm and reflux, mix ethyl acetate with marigold flower granules to extract lutein esters and other fat-soluble substances, until the reflux Ethyl acetate becomes colorless, which means the extraction is complete. Recover the ethyl acetate to obtain the crude extract of lutein ester. Rinse the crude extract 7 times with a mixture of ethanol: propylene glycol = 5:1, heat in vacuum to recover the detergent, add a small amount of Antioxidants were mixed to obtain lutein esters with a content of 59.5%.

Embodiment 3

[0040] Weigh 100g of marigold flower granules, put them into a 2L round bottom flask, add 1.5L of acetone, stir in a water bath at 65°C, keep warm and reflux, mix pure ethyl acetate with marigold flower granules to extract lutein esters and other fat-soluble substances until reflux The ethyl acetate becomes colorless, which means the extraction is complete. The ethyl acetate is recovered to obtain the crude extract of lutein ester. The crude extract is washed with ethanol for 9 times, the detergent is recovered by vacuum heating, and a small amount of antioxidant is added to mix to obtain a content of 69%. of lutein esters (E1102).

[0041] Two, prepare water-soluble type lutein ester microcapsules by above-mentioned lutein ester

[0042] Example 1

[0043] Weigh 20 g of 48% lutein ester (E768) and 1 g of mixed natural vitamin E and place it in a beaker, add 40 g of soybean oil thereinto, place at 90° C. and stir and heat for 20 min to completely dissolve to obtain the lutein...

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Abstract

The invention discloses a lutein ester and a water-soluble lutein ester microcapsule, and preparation methods thereof. Lutein ester is extracted from marigold particles, the lutein ester is obtained after concentration, washing and residue removal, and the lutein ester microcapsule is prepared from the lutein ester through a secondary embedding process. The lutein ester is extracted from the marigold particles, the raw materials are economical and easy to obtain, separation and purification are not carried out, part of medicinal value of the marigold particles is reserved, the health care effect of the lutein ester is improved, meanwhile, the prepared capsule can be more stable and easier to store by adopting the secondary embedding technology, and the lutein ester capsule is suitable forthe fields of foods, medicines and the like. The technical problem of high requirements on extraction equipment in the prior art is effectively solved, so that the technical effects of low equipment requirements, simple process and greatly reduced production cost are achieved.

Description

technical field [0001] The invention belongs to the technical field of deep processing of bioactive substances, and in particular relates to a method for extracting lutein esters and a method for preparing water-soluble lutein ester microcapsules. Background technique [0002] Marigold (Tagetes erecta L) is native to Mexico. It is distributed all over China and can grow at an altitude of 1150 meters to 1480 meters. Its flowers are large and have a long flowering period, and are often used in flower beds. Used as an aromatic agent; previously used as an antibacterial, sedative, and antispasmodic agent. The same plant Tagetesminuta (T. glanduliflora) contains volatile oil, which has sedative, antihypertensive, bronchial expansion, antispasmodic and anti-inflammatory effects. [0003] Lutein esters are carotenoid fatty acid esters. The chemical name is lutein dipalmitate. They are easily soluble in organic solvents. They are widely found in plants such as corn, cabbage, and m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C403/24A61K31/23A61K9/50A61K47/36A61P27/02A61P27/12A61P39/06A61K36/28A23L33/105A23P10/30A23P10/35
CPCC07C403/24A61K36/28A61K31/23A61K9/5036A61P27/02A61P27/12A61P39/06A23L33/105A23P10/30A23P10/35C07C2601/16A23V2002/00A23V2200/224A23V2200/30A23V2300/14A23V2250/21A61P1/00A61K9/1623A61K9/1664A61K9/1652A61K9/1617A61K9/0053A61K31/21A61K2236/00A61K9/5026A61K9/5063A61K9/5089
Inventor 李宏龙徐小松文雁君李林正章文晋於春峰夏慧婷
Owner HENAN ZHONGDA HENGYUAN BIOTECH CO LTD
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