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Composite material for liquid medicine packaging bag

A composite material and packaging bag technology, applied in packaging, wrapping paper, transportation and packaging, etc., can solve the problems of short shelf life, no antibacterial and anti-mildew effect, not durable, etc., and achieve the effect of increasing shelf life

Inactive Publication Date: 2020-10-02
SICHUAN HUILI IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above packaging materials cannot meet the needs well in specific applications.
[0005] In order to better meet the requirements of pharmaceutical packaging materials, it is proposed to use high barrier resin ethylene-vinyl alcohol copolymer, referred to as EVOH, EVOH not only has high gas barrier properties, but also has super oil resistance, organic resistance Solvent performance and environmental protection, so it is favored by pharmaceutical packaging, but EVOH has high cost and poor impact resistance. Studies have proved that the composite material of EVOH and LDPE can reduce the cost of only EVOH on the one hand, and can improve the performance of EVOH. Impact resistance, making it easier to process
[0006] Another requirement for pharmaceutical packaging materials is antibacterial and anti-mildew. Generally, the base material of packaging materials has no direct anti-bacterial and anti-mildew effect. The common method is to sterilize the packaging bags, packaging bottles or packaging films. Add antifungal agent, etc., and then seal it for storage, but in the process of medicinal use, bacteria and mold will inevitably enter, resulting in a relatively short shelf life of the drug. How to improve the antibacterial and antifungal effect of the drug packaging from the packaging materials is the basic principle. One of the problems to be solved in the field
[0007] In the prior art, silver and / or titanium dioxide are often added to the substrate to improve the antibacterial and antifungal effect of the material, but the antibacterial and antifungal effect is uncontrollable and not durable, and needs to be further improved

Method used

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  • Composite material for liquid medicine packaging bag
  • Composite material for liquid medicine packaging bag
  • Composite material for liquid medicine packaging bag

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] like figure 1 As shown, a composite material for a liquid medicine packaging bag is composed of a barrier layer, an antibacterial layer, and a waterproof and breathable layer from the outer layer to the inner layer. The antibacterial layer includes an antibacterial material and a viscose material. The antibacterial material is silver and The composite of PLGA, the viscose material is polyurethane, and the material of the waterproof breathable layer is PE.

[0037] The mass ratio of EVOH and LDPE is 3:1.

[0038] EVOH and LDPE are prepared by conventional co-extrusion method.

[0039] The specific form of the antibacterial layer is: nano silver powder and PLGA are evenly mixed into the viscose layer.

[0040] The specific preparation method is: dissolve PLGA in dichloromethane to form a PLGA solution, add nano-silver powder under stirring conditions and stir evenly, then stir at a low speed until the dichloromethane is completely volatilized to obtain a uniformly mixed...

Embodiment 2

[0048] The difference between this embodiment and Example 1 is that the specific form of the antibacterial material is: silver is the core, PLGA is the microsphere of the shell, the microspheres are distributed in the viscose material, and the shell of PLGA can Nano-silver package, in the early stage, before PLGA is degraded, nano-silver cannot be released. At this time, it can be antibacterial and anti-mildew by the sterilized packaging material or the anti-fungal agent in the drug itself, and as the water vapor in the liquid drug enters To the antibacterial layer, the PLGA shell is degraded until the nano-silver is released, thereby supplementing the antibacterial and antifungal properties of the drug.

[0049] The antibacterial material is prepared by a microemulsion method.

[0050] Specifically, nano-silver is added to the PLGA solution, and is emulsified into microspheres under the stirring condition of a high-pressure homogenizer, and the solution of the PLGA is that PL...

Embodiment 3

[0054] Embodiment 3 The difference between this embodiment and Embodiment 1 is that the mass ratio of EVOH and LDPE is 2:1.

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Abstract

The invention discloses a composite material for a liquid medicine packaging bag. The problems that the antibacterial and mildew-proof effects of a liquid medicine packaging material in the prior artare uncontrollable and not lasting and need to be further improved are solved. The composite material sequentially comprises a blocking layer, an antibacterial layer and a waterproof breathable layerfrom an outer layer to an inner layer, wherein the antibacterial layer comprises an antibacterial material and a viscose material, the antibacterial material is a compound of silver and PLGA, the viscose material is polyurethane, and the waterproof breathable layer is made of polyethylene. The composite material has the advantages of being lasting in antibacterial and mildew-proof effect and the like.

Description

technical field [0001] The invention relates to the technical field of liquid medicine packaging materials, in particular to a composite material for liquid medicine packaging bags. Background technique [0002] As the last link of drug production, drug packaging is also a crucial link. The quality of drug packaging materials directly affects the shelf life and even efficacy of drugs. [0003] The specific requirements of pharmaceuticals for their packaging materials are: high barrier properties, preventing the entry of water vapor and oxygen; ensuring stable drug quality characteristics and ingredients, light weight, easy to carry, cheap, convenient for clinical use, and environmentally friendly. [0004] Existing pharmaceutical packaging materials include plastic, glass, metal, and rubber. For plastic packaging materials, polyethylene, polypropylene, polyester, and polyvinylidene chloride are commonly used. At present, the metals on the market are mainly aluminum materials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B65D65/40B65D65/38
CPCB65D65/40B65D65/38
Inventor 张辉李中明肖瑶
Owner SICHUAN HUILI IND
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