Charge-controllable polymer material as well as preparation method and application thereof

A technology of polymer materials and charges, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of low immunogenicity, hindering clinical transformation, cytotoxicity, etc., and achieve Excellent biocompatibility, prolonged circulation time, and reduced toxic and side effects

Active Publication Date: 2020-10-02
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, positively charged nanomaterials are also prone to non-specific binding to serum proteins and normal cells, causing immune reactions, cytotoxicity, and reducing drug delivery efficiency, hindering its clinical transformation
In contrast, non-positively charged nanomaterials (i.e., negatively charged or near-neutrally charged) usually exhibit high biocompatibility and low immunogenicity, but are generally difficult to be taken up by cells.

Method used

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  • Charge-controllable polymer material as well as preparation method and application thereof
  • Charge-controllable polymer material as well as preparation method and application thereof
  • Charge-controllable polymer material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Investigate the ability of polymer materials to form coatings on the surface of different materials.

[0047] The polymer material coating of this embodiment is prepared by the following method:

[0048] Mix absolute ethanol, ammonia water, and deionized water at a ratio of 0.5:0.03:1, add Tween 80 solution (final concentration: 10 mM) and stir evenly. Disperse the pre-prepared macroscopic materials glass, plastic, tin foil, or microscopic materials Au NPs, ZnONPs and MSN NPs in the above mixed system, and then add DA and 5-HT in the ratio of 2:3 to the above reaction system in sequence, room temperature Stir in the dark for 24h, then stop stirring. After removing the supernatant, the precipitate was washed 3 times with deionized water to form a PDH coating on the surface of the material.

experiment example

[0050]1. Appearance of macroscopic materials: photographic records of macroscopic materials such as glass, plastic, and tin foil before and after coating with polymer materials. figure 1 Appearance of PDH coating formed on the surface of glass, plastic and tinfoil. It can be seen from the figure that the PDH prepared by the present invention can form a coating on the surface of macroscopic materials such as glass, plastic, and tin foil.

[0051] 2. Microscopic material morphology: observe the morphological changes of Au NPs, ZnO NPs, and MSN NPs before and after coating with PDH. The detection method of the morphology: the sample is dropped on a 400-mesh copper grid covered with a carbon film, placed in a desiccator, and waited for After natural drying, observe under a transmission electron microscope Titan G2-F20. figure 1 It is a transmission electron microscope image of Au, Au / PDH; ZnO, ZnO / PDH; MSN, MSN / PDH NPs. It can be seen from the figure that the PDH prepared by the ...

Embodiment 2

[0054] The PDH coating self-aggregated to form NPs.

[0055] The polymer nanoparticles of this embodiment are prepared by the following method:

[0056] Mix absolute ethanol, ammonia water, and deionized water at a ratio of 0.5:0.03:1, add Tween 80 solution (final concentration is 10mM) and stir evenly; mix different ratios (5-HT:DA 5:0, 4 :1, 3:2, 2:3, 1:4, 0:5, the total monomer concentration is 1.5mg〃mL -1 ) of DA and 5-HT hydrochloride solution were added to the above reaction system, and stirred at room temperature in the dark for 24 hours until the color deepened (such as figure 2 A), stop stirring; centrifuge at 20000rpm for 30min to remove the supernatant, and wash the precipitate with deionized water for 3 times to obtain PDH NPs; characterize the particle size and potential of NPs in different pH environments, and select a suitable 5-HT :DA ratio to further investigate the correlation between the particle size potential of NPs and the total concentration of monome...

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Abstract

The invention provides a charge-controllable polymer material as well as a preparation method and application thereof. The polymer material is synthesized from dopamine and 5-hydroxytryptamine. The preparation method of the material comprises the following steps of: adding dopamine and a 5-hydroxytryptamine hydrochloride solution into a stirred alcohol ammonia solution according to a certain ratio, and stirring for 24 hours at room temperature in a dark place to form the polymer material. The polymer material has the advantages of excellent adhesion, secondary modification, charge controllability and the like, can be used for surface modification of most materials or directly used for drug delivery, and has a huge application prospect in many fields.

Description

technical field [0001] The invention relates to the field of nano-biotechnology, in particular to a charge-controllable polymer material and its preparation method and application. Background technique [0002] The surface properties of a material have an important influence on the application of the material. For example, the surface coating of glass can change the light reflection and light transmission of glass, the surface coating of tires can change the friction and maneuverability, and the surface charge of the material directly affects its adsorption performance (the same sex attracts, the opposite sex repels the principle) Wait. Therefore, it is of great significance to modify the surface of materials and control the surface electrical properties. At the same time, the surface properties of nanomaterials have an important impact on their biomedical applications. With the rapid development of nanotechnology, various nanomaterials and their composites have been wide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/06A61K47/34A61K45/00A61P35/00
CPCA61K45/00A61K47/34A61P35/00C08G73/0672
Inventor 周文虎朱皎皎孟英才余梦真
Owner CENT SOUTH UNIV
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