Method for detecting concentration of antiepileptic drug in serum
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An anti-epileptic drug and concentration technology, which can be used in measurement devices, instruments, scientific instruments, etc., can solve the problems of long sample collection time, high configuration requirements, and long sample collection time.
Pending Publication Date: 2020-10-23
南京品生医学检验实验室有限公司
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The article "Simple and AccurateQuantitative Analysis of Ten Antiepileptic Drugs in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry" reported a method for the simultaneous detection of ten antiepileptic drugs. Only two isotope internal standards were used for the ten substances, and matrix interference would be relatively large. Sample collection The time is relatively long, a
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Embodiment 1
[0082] 1. Experimental materials and instruments
[0083] 1. Materials
[0084] The samples came from serum samples collected from the outpatient clinic of Shanghai Zhongshan Hospital in November 2019.
[0086] (2) Reagent consumables: MS grade methanol (Fisher, USA); HPLC grade methanol (Honeywell, USA); MS grade acetonitrile (Fisher, USA); HPLC grade acetonitrile (Honeywell, USA); MS grade formic acid (Fisher, USA) ;Column model: ACQUITY UPLC BEH C 18 (2.1 x 50 mm, 1.7 μm) (Waters Corporation).
[0087] (3) Standards: Stand...
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Abstract
The invention relates to a method for detecting the concentration of an antiepileptic drug in serum. The method is high in sensitivity, high in specificity, good in accuracy and simple in pretreatmentprocess, separation and detection of the antiepileptic drug in serum are completed within 6.0 min, the accuracy and precision of the method basically meet requirements, the method can be used for quantitative analysis of the antiepileptic drugs in the serum clinically, and a simple and rapid detection method is provided for concentration monitoring of the antiepileptic drugs clinically.
Description
technical field [0001] The invention belongs to the technical field of blood detection, and specifically relates to a method for detecting the concentration of antiepileptic drugs in serum, wherein the antiepileptic drugs are respectively: levetiracetam (Levetiracetam, LTT), 10-hydroxycarbazepine (Hydroxycarbazepine, HCBZ ), carbamazepine (CBZ), oxcarbazepine (Oxcarbazepine, OCP), phenytoin (5,5-Diphenylhydantoin, PHT), lamotrigine (Lamotrigine, LMT), valproic acid (2-Propylpentanoic acid, VPA), phenobarbital (Phenobarbital, PBB), topiramate (Topiramate, TPM) and clonazepam (Clonazepam, CNP). Background technique [0002] Epilepsy is a group of chronic diseases caused by a variety of etiologies, with sudden abnormal discharge of brain neurons, characterized by recurrent, paroxysmal, and stereotyped central nervous system dysfunction, leading to transient brain dysfunction. The etiology of epilepsy is complex and diverse, including genetic factors, brain diseases, systemic o...
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