Production method of aspirin enteric-coated tablets and powder adding device

Abstract

The invention discloses a production method of aspirin enteric-coated tablets. The production method comprises the following steps: sieving corn starch, crushing cane sugar, granulating dextrin, the sieved corn starch and the crushed cane sugar to obtain blank particles; respectively weighing aspirin, blank particles and dry corn starch, sequentially putting the aspirin, the blank particles and the dry corn starch into a blending barrel, adding the weighed dry corn starch into the blending barrel, and carrying out total mixing and tabletting on the blended aspirin, blank particles and dry cornstarch. The aspirin enteric-coated tablet prepared by mixing the blank particles and aspirin can effectively prevent aspirin from being heated, prevent external moisture from permeating, prevent aspirin hydrolysis and effectively reduce the content of free salicylic acid; meanwhile, aspirin is prevented from disintegration in gastric juice, and the disintegration and dissolution effects of aspirin in the intestinal tract are guaranteed.

Description

technical field [0001] The invention relates to the technical field of tablet production, in particular to a production method of aspirin enteric-coated tablets and a powder adding device. Background technique [0002] Aspirin is an antipyretic and analgesic drug with multiple functions. It was first used for antipyretic and analgesic, and now it is mostly used to prevent diseases such as thrombosis. In addition, aspirin also has the effect of reducing mucocutaneous lymph node syndrome. [0003] Salicylic acid is the main component of aspirin, the product obtained by the hydrolysis of acetylsalicylic acid, and the main component that brings about the side effects of aspirin. Because acetylsalicylic acid is easily hydrolyzed to generate salicylic acid, the aspirin tablets in the prior art more or less all contain a certain amount of free salicylic acid. Headache, dizziness, nausea, vomiting, tinnitus, loss of vision and hearing, etc. may occur, and in severe cases, symptoms...

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Problems solved by technology

[0005] For this reason, the present invention provides a kind of production method of aspirin enteric-coated tablet and powder adding device, in order to solve the production process of existing aspirin enteric-coated tablet in the prior art, needs to add appropriate amount of water to carry out the procedures such as granulation, This leads to the formation of salicylic acid. At the same time, most of the raw materials in aspirin enteric-coated tablets are powders, and it is difficult to accurately control the weight of powders when adding them, so that the ratio of aspirin enteric-coated tablets cannot be well controlled, which affects the aspirin enteric-coated tablets. The problem of the quality of the solution

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