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Traditional Chinese medicine composition with anti-allergic effect and preparation method of traditional Chinese medicine composition

A composition and anti-allergic technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, drug combinations, etc., can solve the problem that the therapeutic effect cannot meet our needs, the preparation process is complicated, the solubility is low, etc. It can improve the absorption and utilization rate of drugs, the extraction process is efficient and simple, and the process design is reasonable.

Inactive Publication Date: 2020-11-20
SHANGHAI JAKA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Nowadays, with the advancement and development of science and technology, skin eczema has become a problem that we are paying more and more attention to. However, the formulations of medicines that can relieve symptoms such as eczema and atopic dermatitis allergies are relatively complicated, and the preparation process is complicated. Most of the medicines contain natural Plant extracts, this component has poor stability, low solubility, and the therapeutic effect cannot meet our needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0057] S1: Prepare materials;

[0058] S2: Preparation of the first extract:

[0059] Take anhydrous pyridine, add chlorosulfonic acid in an ice-water bath to obtain material A; take lecithin and cholesterol, mix and stir for 5 minutes, add absolute ethanol to dissolve, and obtain material B;

[0060] Take the white fresh skin, crush it, extract it under reflux with 90% ethanol, filter it, dry it in the shade, extract it under reflux twice, filter it, combine the filtrate, add N,N-dimethylformamide, stir for 10 minutes, then add material A, 60°C The reaction was stirred for 3 hours, cooled to room temperature, adjusted to pH 7, precipitated with ethanol for 24 hours, centrifugally filtered, and dialyzed for 72 hours to obtain a mixed solution;

[0061] Take the mixed solution and 1,2-propanediol, mix and stir, dissolve the phosphate buffer solution, then add material B, ultrasonicate for 30s, then place it in a water bath at 40°C, and rotate under reduced pressure until a fil...

example 2

[0074] S1: Prepare materials;

[0075] S2: Preparation of the first extract:

[0076] Take anhydrous pyridine, add chlorosulfonic acid into an ice-water bath to obtain material A; take lecithin and cholesterol, mix and stir for 7 minutes, add absolute ethanol to dissolve, and obtain material B;

[0077] Take white fresh skin, crush it, extract it under reflux with 90% ethanol, filter it, dry it in the shade, extract it under reflux three times, filter it, combine the filtrate, then add N,N-dimethylformamide, stir for 12min, then add material A, 63℃ The mixture was stirred and reacted for 3.2 hours, cooled to room temperature, adjusted to pH 7, ethanol precipitated for 26 hours, centrifugally filtered, and dialyzed for 72 hours to obtain a mixed solution;

[0078] Take the mixed solution and 1,2-propanediol, mix and stir, dissolve the phosphate buffer solution, then add material B, ultrasonicate for 40s, then place it in a water bath at 43°C, and rotate under reduced pressure ...

example 3

[0091] S1: Prepare materials;

[0092] S2: Preparation of the first extract:

[0093]Take anhydrous pyridine, add chlorosulfonic acid in an ice-water bath to obtain material A; take lecithin and cholesterol, mix and stir for 8 minutes, add absolute ethanol to dissolve, and obtain material B;

[0094] Take white fresh skin, crush it, extract it under reflux with 90% ethanol, filter it, dry it in the shade, extract it under reflux three times, filter it, combine the filtrate, then add N,N-dimethylformamide, stir for 15 minutes, then add material A, and heat at 65°C The mixture was stirred and reacted for 3.5 hours, cooled to room temperature, adjusted to pH 7, ethanol precipitated for 28 hours, centrifugally filtered, and dialyzed for 72 hours to obtain a mixed solution;

[0095] Take the mixed solution and 1,2-propanediol, mix and stir, dissolve the phosphate buffer solution, then add material B, ultrasonicate for 50s, put it in a water bath at 45°C, and rotate under reduced p...

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Abstract

The present invention discloses a traditional Chinese medicine composition with an anti-allergic effect and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises a first extract, a second extract, a third extract, a fourth extract, a surfactant and an auxiliary agent, wherein the first extract is prepared from cortex dictamni,anhydrous pyridine, lecithin and other components. The cortex dictamni is dried root barks of rutaceae plant dictamnus dasycarpus and rich in polysaccharides, alkaloids, flavonoids and other ingredients, has effects of clearing heat and drying dampness, dispelling wind and removing toxins, and removing damp-heat and sore-toxin, can be used for skin diseases such as skin pruritus, urticaria and eczema, and has strong anti-allergic and anti-itching effects. The disclosed traditional Chinese medicine composition with the anti-allergic effect is reasonable in process design and adapted in formulacomponents, has excellent anti-microorganism and anti-inflammatory effects, can treat skin surface eczema, atopic dermatitis and other allergic symptoms, also has long-term stability, and reduces lossof medicines.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with antiallergic effects and a preparation method thereof. Background technique [0002] Eczema is a severe itching skin inflammatory reaction caused by various internal and external factors, and it is also one of the most common skin allergy symptoms. Eczema can be divided into three stages: acute, subacute, and chronic. Then infiltration, hypertrophy. Some patients directly show as chronic eczema, and eczema has characteristics such as pleomorphism, symmetry, itching and easy recurrence. [0003] Nowadays, with the advancement and development of science and technology, skin eczema has become a problem that we are paying more and more attention to. However, the formulations of medicines that can relieve symptoms such as eczema and atopic dermatitis allergies are relatively complicated, and the preparation process...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61K47/24A61K47/28A61P37/08A61P17/00
CPCA61K36/282A61K36/488A61K36/65A61K36/71A61K36/75A61K36/752A61K36/8962A61K47/24A61K47/28A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61P17/00A61P37/08A61K2300/00
Inventor 田军卢伊娜
Owner SHANGHAI JAKA BIOTECH CO LTD
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