Polyethyleneimine modified porous silicon dioxide-coating LDH core-shell nano composite material and preparation method thereof

A technology of porous silica and nanocomposite materials, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as poor biological stability, and achieve the effect of low cost, simple operation, and promotion of DC maturity.
CN112007015AInactive Publication Date: 2020-12-01HEILONGJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEILONGJIANG UNIV
Publication Date
2020-12-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a polyethyleneimine modified porous silicon dioxide-coating LDH core-shell nano composite material and a preparation method thereof, and relates to a core-shell structure nanocomposite material and a preparation method thereof. The problems that plasmid DNA combined by an existing LDH-coated SiO2 shell-core nano composite material is easily degraded by nuclease, and the biological stability is poor are solved. The method comprises the following steps: 1, preparing aminated porous silicon dioxide; 2, preparing carboxylated porous silicon dioxide; 3, preparing polyethyleneimine modified porous silicon dioxide; and 4, preparing the polyethyleneimine modified porous silicon dioxide-coating LDH core-shell nano composite material. According to the core-shell nano composite material prepared by the method, plasmid DNA cannot be recognized by protease and nuclease and cannot be degraded, and the core-shell nano composite material has very high biological stability. Theinvention is applied to the field of gene delivery vector materials.
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Description

technical field

[0001] The invention relates to a core-shell structure nanocomposite material and a preparation method thereof. Background technique

[0002] Silica nanoparticles have attracted increasing attention due to their high thermal / chemical stability, large specific surface area, uniform and controllable pore size and particle size, and strong modifiability. At the same time, silica nanoparticles can be biodegraded in the body to generate silicic acid, which can be absorbed by the human body or excreted through the urinary system, which has good biological safety. These characteristics of silica nanoparticles make it a potential nano-drug carrier and gene carrier, with many advantages, such as protecting DNA from nuclease degradation, good penetration effect, and can directly enter cells through biomembrane barriers, Plasmid DNA is released and the corresponding protein is expressed; it is effectively taken up by antigen-presenting cells, processed and presented to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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