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A kind of spherical selenium nanoparticle and preparation method thereof

A selenium nano-particle technology, applied in the fields of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problem that the surface modifier cannot perform sufficient surface modification, and the Se source and reducing agent cannot be fully contacted and reacted , complex synthesis methods, etc., to achieve the effect of reducing particle size, increasing the number of nucleation, and accelerating the nucleation speed.

Active Publication Date: 2022-03-25
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At present, most of the methods for preparing Se nanoparticles have problems such as high preparation cost and complicated synthesis methods. Although there are reports on the method of synthesizing Se nanoparticles by low-heat solid-phase method, there are still certain defects. The grinding process of nanoparticles in the report It is to mix the Se source, reducing agent and surface modifier together, which will cause the Se source and reducing agent to not fully contact and react under the condition of the presence of the surface modifying agent, the reduction is not complete, and the surface modifying agent cannot perform sufficient surface modification The problem

Method used

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  • A kind of spherical selenium nanoparticle and preparation method thereof
  • A kind of spherical selenium nanoparticle and preparation method thereof
  • A kind of spherical selenium nanoparticle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] (1) Weigh 0.11g of selenium dioxide and 0.36g of ascorbic acid, the molar ratio of the two is 1:2, put them into a mortar, mix them, and grind them at 20°C for 1 to 10 minutes until they become a red paste;

[0050] (2) Add 20 mL of deionized water to the red paste obtained by grinding in step (1) to disperse;

[0051] (3) Pour the solution obtained in step (2) into a container, add 47 mg of polyvinylpyrrolidone (PVP) to it, carry out ultrasonic treatment at 20°C and 300W for 60min, and centrifuge at 4°C and 10000r / min after the treatment is completed. The supernatant and the precipitate were freeze-dried separately to finally obtain Se nanoparticles.

[0052] figure 1 is a TEM photo of Se nanoparticles taken by a transmission electron microscope (TEM), figure 2 It is obtained by X-ray electron spectroscopy (XPS) test; As can be seen from the figure, the selenium nanoparticle size is 40nm, and the shape is spherical ( figure 1 ); wherein the chemical valence of Se i...

Embodiment 2

[0056] Adjust the mol ratio of selenium dioxide and ascorbic acid in embodiment 1 to be 1:1, 1:3, 1:4 respectively, keep the add-on of polyvinylpyrrolidone (PVP) and account for 10% of the total mass of selenium dioxide and ascorbic acid, Other parameters and preparation method all remain unchanged, obtain the character of Se nanoparticle, as shown in table 2:

[0057] Table 2

[0058] Proportion Size (nm) Hydration radius (nm) Surface charge (eV) 1:1 9 200 -0.06 1:3 65 160 1.32 1:4 50 110 2.66

[0059] Figure 3-5 It is the Se nanoparticle TEM photograph prepared in embodiment 2, wherein image 3 The ratio of selenium dioxide and ascorbic acid is a TEM photo of Se nanoparticles prepared in 1:1, Figure 4 TEM photograph of Se nanoparticles prepared for a ratio of selenium dioxide and ascorbic acid of 1:3, Figure 5 TEM photograph of Se nanoparticles prepared for a ratio of 1:4 of selenium dioxide and ascorbic acid. As can be seen f...

Embodiment 3

[0061] Change the Se source in embodiment 1 to be sodium selenite and selenic acid respectively, keep the mol ratio of Se source and ascorbic acid to be 1:2, keep the add-on of polyvinylpyrrolidone (PVP) accounting for selenium dioxide and ascorbic acid total mass 10%, other parameters and preparation method all remain unchanged, obtain the character of Se nanoparticle, as shown in table 3:

[0062] table 3

[0063] Proportion Size (nm) Hydration radius (nm) Surface charge (eV) Sodium Selenite 50 140 -1.08 selenic acid 40 120 1.13

[0064] Figure 6 It is the Se nanoparticle TEM photograph (selenium source is sodium selenite) prepared in embodiment 3, Figure 7 It is a TEM photo of Se nanoparticles prepared in Example 3 (the selenium source is selenic acid). The particle size of selenium nanoparticles obtained by changing the selenium source will be different. When selenic acid is used as the selenium source, the surface of the selenium n...

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Abstract

The invention discloses a spherical selenium nanoparticle and a preparation method thereof, belonging to the technical field of nanomaterial preparation. The invention adopts a low-heat solid-phase method, utilizes different Se sources and different reducing agents, firstly synthesizes Se nanoparticles quickly, and then synthesizes Se nanoparticles modified by different surface modifiers under the action of ultrasound and surface modifiers in the later stage, and adopts centrifugal separation The product was separated by method, and spherical Se nanoparticles with different sizes were finally obtained. The function of ultrasound is to accelerate the nucleation speed of the experimental product, increase the number of nucleation, and reduce the particle size. In the present invention, the surface modifier is added in the later stage, one is to make the product formation process in the early stage more complete and thorough, and the other is to modify the surface of the formed product so that it has different charges, and particles with different charges enter the organism. The degree of difficulty is different, and neutral and negative charges are more likely to enter the organism to produce effects.

Description

technical field [0001] The invention relates to a spherical selenium nanoparticle and a preparation method thereof, belonging to the technical field of nanomaterial preparation. Background technique [0002] Selenium (Se) is an element particularly beneficial to human health. Studies have shown that Se is a constituent element of glutathione peroxidase in the human body and an important component for maintaining the activity of various enzymes. It has functions such as anti-oxidation, anti-cancer and improving immunity in the human body. Low Se or Se deficiency populations can not only prevent the occurrence of tumors and liver diseases by supplementing selenium in an appropriate amount, but also improve the immune ability of the body, maintain the normal functions of important organs such as the heart, liver, lungs, and stomach, and prevent the development of senile heart and cerebrovascular diseases. occur. Se is not only beneficial to the human body, but also has certai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B19/02B82Y30/00B82Y40/00C05G3/50C05G5/12
CPCC01B19/02B82Y30/00B82Y40/00C05G3/50C05D9/02C05G5/12C01P2004/04C01P2004/64C01P2002/85C01P2004/32
Inventor 王震宇王传洗乐乐曹雪松
Owner JIANGNAN UNIV
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