Anti-inflammatory composition, preparation method and application

Abstract

The invention discloses an anti-inflammatory composition, a preparation method and an application. The anti-inflammatory composition comprises beta-sitosterol, pseudo-ceramide, glycyrrhetinic acid compounds and fatty acid compounds. The composition has the technical effects that the beta-sitosterol, the pseudo-ceramide and the fatty acid compounds are adopted, so that repair of lipid bilayers of skin cells in an inflammatory region is promoted, the barrier function of the skin in the inflammatory region is recovered, and the anti-inflammatory factor capacity of the skin is improved; the anti-inflammatory effect of the composition is improved through cooperation with an anti-inflammatory agent; the pseudo-ceramide is easy to absorb and can promote cell synthesis to supplement ceramide in the lipid bilayers; and the beta-sitosterol can play a role of a fatty acid compound antioxidant, so that stimulation to the skin after peroxidation of the fatty acid compound is avoided, the use amountof the fatty acid compound in the composition is increased, recovery of the lipid bilayers of the skin cells is further promoted, and the anti-inflammatory factor capacity of the composition is improved.

Description

technical field [0001] The invention relates to the fields of skin anti-inflammatory preparations and fat replacement preparations, in particular to an anti-inflammatory composition, preparation method and application. Background technique [0002] When skin inflammation occurs, anti-inflammatory preparations can be used to treat the skin externally. When inflammation occurs, skin lipids will be lost, which will reduce the ability of anti-inflammatory factors in skin cells and lower the barrier function of the skin, leading to further development of inflammation and slow recovery . [0003] In the prior art, the external application preparation used in the case of skin inflammation uses a combination of anti-inflammatory agent and lipid, wherein the anti-inflammatory agent is used to play an anti-inflammatory effect, and the lipid is used to form a layer of lipid film on the skin surface, through which the lipid film The water-absorbing and water-storage properties of the s...

AI Technical Summary

Problems solved by technology

[0002] When skin inflammation occurs, anti-inflammatory preparations can be used to treat the skin externally. When inflammation occurs, skin lipids will be lost, which will reduce the ability of anti-inflammatory factors in skin cells and lower the barrier function of the skin, leading to further development of inflammation and slow recovery

[0003] In the prior art, the external application preparation used in the case of skin inflammation adopts the combination of anti-inflammatory agent and lipid, wherein the anti-inflammatory agent is used to play an anti-inflammatory effect, and the lipid is used to form a layer of lipid film on the skin surface, and the lipid film passes through the lipid film. The water-absorbing and water-storage properties of the skin can moisturize the skin and reduce the discomfort of the skin, but none of them can improve the anti-inflammatory factor ability of the skin cells themselves; at the same time, the lipid film affects the normal physiological functions of the cells

External application preparations mainly include the following dosage forms: cream, which contains a large amount of emulsifier, which has a wash-off effect, and the use of a large amount of emulsifier will lead to further loss of skin surface lipids, making the skin dry and aggravating the effect of skin inflammation; water-based Preparations, which cannot be miscible with lipids, need to use solubilizers such as emulsifiers to disperse lipids, but the addition of solubilizers will still cause further loss of lipids on the skin surface; encapsulated dosage forms, which have a monolayer of water and oil on the microscopic scale Or multi-layered small particles, which have good water-oil dispersion effect, but the preparation process is extremely complicated and the formulation stability is poor

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