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Product for inhibiting viruses and application

A product, virus technology, applied in the field of virus suppression products, can solve problems such as waste, underutilization of natural resources, pollution of the natural environment, etc., and achieve remarkable effects, remarkable application effects, and remarkable suppression effects

Pending Publication Date: 2021-01-15
JIANGSU TAIDE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As traditional food and traditional Chinese medicine raw materials, kelp contains a large amount of fucoidan sulfate residues in traditional processing, which are usually discarded without further processing and utilization, which not only pollutes the natural environment, but also makes precious natural resources Not being fully utilized, resulting in great waste

Method used

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  • Product for inhibiting viruses and application
  • Product for inhibiting viruses and application
  • Product for inhibiting viruses and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Extraction of Fucoidan Sulfate

[0036] Process 1: The conventional extraction, separation and purification process of laminaria fucoidan sulfate (see the literature "Nishino, T. et al: Carbohydr. Res . 1989, 186:119-129."), its preparation method is as follows:

[0037] Kelp (purchased in the market, 100 grams) → dried (60 o C)→crushing→kelp powder (60 mesh)→add acetone (2,000 mL, soak three times, 12h each time)→filter→filter residue→dry (60 o C) → hot water extraction (water 4 L, soaked three times, 80 ~ 95 o C) → filtrate → concentrated under reduced pressure (65 oBelow C) → ethanol (ethanol concentration reaches 30, 70, 85% respectively) → precipitation → crude fucoidan sulfate → make 3% polysaccharide aqueous solution → anion exchange resin (anion exchange resin of Q- Sepharose FF, use H 2 0, 1.0 mol / L and 2.0 mol / L NaCl solution for stepwise elution)→concentration under reduced pressure (65 o Below C)→freeze drying→Fucoidan sulfate (brown powder);...

Embodiment 2

[0042] Example 2 Comparison of Extraction Processes of Laminaria Fucoidan Sulfate

[0043] 1. Experiments were carried out according to the process 1, 2, and 3 for the extraction, separation and purification of fucoidan sulfated laminaria in Example 1, and the weight (mg) of fucoidan laminaria sulfate before and after electron beam irradiation was compared.

[0044] Test results are shown in Tables 1, 2, 3 and figure 1 :

[0045] Extraction time (hours) Experiment 1 Experiment 2 Experiment 3 average Standard deviation (±) 0 0.0000 0.0000 0.0000 0.0000 0.0000 2 2.3010 2.2789 2.3109 2.2969 0.0164 4 3.0123 3.0563 3.0875 3.0520 0.0378 S 3.6801 3.7761 3.7901 3.7488 0.0599 10 3.9806 3.8991 3.9012 3.9270 0.0465 12 4.1205 4.0789 4.0945 4.0980 0.0210

[0046] Promotion time (hours) Real light 1 Experiment 2 Real lights 3 average Standard deviation (±) 0 0.0000 0.0000 0.0000 0.0000...

Embodiment 3

[0064] A virus-inhibiting product, the raw materials and parts by weight are 9 parts of sea salt, 0.1 part of sodium bicarbonate, 0.3 part of citric acid, 0.2 part of sodium citrate, 0.5 part of fucoidan sulfate, prepared into 0.6% by using clean water as a solvent Nasal rinse / nasal spray in (gram / ml) concentration for use in combination with nasal spray or nebuliser for the prevention and treatment of COVID-19 / flu, silicosis, and the treatment of rhinitis, and / or sinusitis, and / or allergic rhinitis.

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Abstract

The invention discloses a medicine for inhibiting viruses, wherein the medicine comprises fuciodan, the viruses are coronavirus and / or avian influenza virus, and further, the coronavirus is gamma coronavirus. The fucoidan and a composition thereof have an inhibition effect on gamma coronavirus (respiratory coronavirus) and avian influenza virus.

Description

technical field [0001] The invention relates to a product for suppressing viruses, in particular to a product for suppressing coronaviruses and / or avian influenza viruses, a preparation method and use thereof. Background technique [0002] Fucoidan sulfate (Fuciodan, also known as fucoidan sulfate, fucoidan sulfate, etc.) is a unique natural water-soluble active polysaccharide containing sulfate in brown algae. It is a water-soluble polysaccharide containing sulfate Heteroglycans, a unique chemical component in brown algae, are metabolites of the interstitial cells of brown algae. At present, the main raw materials that can be used to extract fucoidan sulfate are kelp, seaweed, Ascophyllum nodosum, scalloped seaweed, sargassum, rope algae, etc., and the industrial production is mainly achieved by the first three. [0003] Kelp (Laminaria japonica), also known as Lunbu or Kelp, belongs to Phaeophyta, Laminaria, Laminariaceae, and Laminaria genus. It is a large edible seaweed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K33/14A61P31/14A61P31/16A61P11/02A61P37/08C08B37/00A61K31/194A61K33/00
CPCA61K31/194A61K31/737A61K33/00A61K33/14A61P11/02A61P31/14A61P31/16A61P37/08C08B37/0003C08B37/0063A61K2300/00
Inventor 张丽欣邓博
Owner JIANGSU TAIDE PHARMA CO LTD
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