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Preparation method of low-aldehyde alpha-cyanoacrylate medical adhesive

A cyanoacrylic acid and adhesive technology, which is applied in the preparation of organic compounds, the preparation of carboxylic acid nitrile, and surgical adhesives, etc., can solve the problem of high formaldehyde content, and achieve high bonding strength, simple operation, and good film-forming properties. Effect

Active Publication Date: 2021-01-26
诺一迈尔(山东)医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The object of the present invention is to provide a kind of preparation method of simple low-aldehyde α-cyanoacrylate medical adhesive, the preparation method of the present invention overcomes the higher formaldehyde content in the existing α-cyanoacrylate synthetic method defects, avoiding adverse symptoms such as skin allergic reactions and irritations caused by excessive formaldehyde content; and improving the bonding strength

Method used

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  • Preparation method of low-aldehyde alpha-cyanoacrylate medical adhesive

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Effect test

Embodiment 1

[0029] A preparation method of low aldehyde α-cyanoacrylate medical adhesive, specifically as follows:

[0030] One, the preparation of paraformaldehyde reaction solution:

[0031] Add paraformaldehyde and 1,8-diazabicycloundec-7-ene (organic base) into ethyl acetate (dehydrating agent), and react at 40°C for 1 hour to prepare paraformaldehyde reaction liquid; control the concentration of the paraformaldehyde in the ethyl acetate to be 0.3g / mL; the concentration of the 1,8-diazabicycloundec-7-ene in the ethyl acetate 5mg / mL;

[0032] 2. Preparation of low-aldehyde α-cyanoacrylate medical adhesives:

[0033] (1) Take 200.0 g of the paraformaldehyde reaction solution prepared above, 2.0 g of cetylpyridinium bromide and 70.0 g of triisobutyl phosphate and mix them uniformly, and heat to 45° C. to obtain a mixed solution;

[0034] (2) then add 320.0g n-butyl cyanoacetate in the mixed solution, and react for 2 hours;

[0035] (3) After the reaction, add 16.0 g of sulfuric acid ...

Embodiment 2

[0038] A preparation method of low aldehyde α-cyanoacrylate medical adhesive, specifically as follows:

[0039] One, the preparation of paraformaldehyde reaction solution:

[0040] Add paraformaldehyde and 2-picoline (organic base) into cyclopentane (dehydrating agent), and react at 60° C. for 0.5 hour to prepare a paraformaldehyde reaction liquid; control the paraformaldehyde in the The concentration in cyclopentane is 0.2g / mL; the concentration of the 2-picoline in the cyclopentane is 4mg / mL;

[0041] 2. Preparation of low-aldehyde α-cyanoacrylate medical adhesives:

[0042] (1) Take 250.0 g of the paraformaldehyde reaction solution prepared above, 1.5 g of octadecyldimethylbenzyl quaternary ammonium chloride and 65.0 g of dioctyl p-hydroxyphthalate and mix them uniformly, and heat to 50°C , to obtain a mixture;

[0043] (2) Then add 350.0 g of isooctyl cyanoacetate in the above mixed solution, and react for 1.5 hours;

[0044] (3) After the reaction, add 15.0 g of boron...

Embodiment 3

[0047] A preparation method of low aldehyde α-cyanoacrylate medical adhesive, specifically as follows:

[0048] One, the preparation of paraformaldehyde reaction solution:

[0049] Add paraformaldehyde and ethylenediamine (organic base) to petroleum ether (dehydrating agent), and react at 50°C for 2 hours to prepare a paraformaldehyde reaction liquid; control the paraformaldehyde in the petroleum ether The concentration of the ethylenediamine is 0.2g / mL; the concentration of the ethylenediamine in the petroleum ether is 2mg / mL;

[0050] 2. Preparation of low-aldehyde α-cyanoacrylate medical adhesives:

[0051] (1) Take 220.0 g of the paraformaldehyde reaction solution prepared above, 2.5 g of ammonium dodecylbenzenesulfonate and 50.0 g of (2-ethylhexyl) phthalate and mix them uniformly, and heat to 60° C. to obtain mixed solution;

[0052] (2) Then add 300.0 g of isooctyl cyanoacetate to the above mixed solution, and react for 1 hour;

[0053] (3) After the reaction, add 2...

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Abstract

The invention discloses a preparation method of a low-aldehyde alpha-cyanoacrylate medical adhesive. The method comprises the following steps: preparation of paraformaldehyde reaction liquid: adding paraformaldehyde and organic alkali into a dehydrating agent for a reaction to prepare the paraformaldehyde reaction liquid; and preparation of the low-aldehyde alpha-cyanoacrylate medical adhesive: (1) mixing the paraformaldehyde reaction liquid, a catalyst and a heat conduction solution, and carrying out heating to obtain a mixed solution; (2) adding cyanoacetate into the mixed solution for a reaction; (3) after the reaction, adding a polymerization inhibitor to terminate a polymerization reaction, adding a stabilizer, and cracking the reaction product to obtain a crude alpha-cyanoacrylate product; and (4) distilling the crude alpha-cyanoacrylate product, and carrying out sterile filtration to obtain the low-aldehyde alpha-cyanoacrylate medical adhesive. The preparation method disclosed by the invention is simple, the prepared alpha-cyanoacrylate medical adhesive is low in formaldehyde content, and the low-aldehyde alpha-cyanoacrylate medical adhesive is good in film-forming property,high in bonding strength and excellent in stability.

Description

technical field [0001] The invention relates to the technical field of medical adhesives, in particular to a preparation method of a low-aldehyde α-cyanoacrylate medical adhesive. Background technique [0002] With the continuous development of science and technology and medical level, and the continuous improvement of people's requirements for the quality and efficiency of medical treatment, there are more and more types of medical adhesives, which can be mainly divided into two categories, namely, soft tissue adhesives And hard tissue adhesives, among which soft tissue adhesives can be used for bonding skin, organs, nerves, blood vessels, mucous membranes and other parts, most of which use medical α-cyanoacrylate glue and fibrin biotype glue, Since fibrin bio-glue is produced in blood, there is a possibility of mutual transmission of infectious diseases such as hepatitis and AIDS during use. Although autologous blood can be used, it is not suitable for emergency treatment,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C253/30C07C253/34C07C255/23A61L24/00
CPCC07C253/30C07C253/34A61L24/00C07C255/23
Inventor 李强张文彩郭刚王丽王志修
Owner 诺一迈尔(山东)医学科技有限公司
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