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Application of polyurethane-based interpenetrating network polymer in surface modification of medical catheter

An interpenetrating network and polyurethane-based technology, applied in the field of functional polymer materials, can solve the problems of complex process, high cost, storage stability of isocyanate-terminated prepolymers, etc.

Active Publication Date: 2021-01-29
JIANGSU OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Photochemical grafting modification of the surface of the catheter substrate to obtain hydrophilic and antibacterial properties requires high technical requirements and a relatively complicated process. In addition, the production of homopolymers is also the reason for the high cost of this method
CN109354706 uses functionalized isocyanate-terminated prepolymers to chemically modify the surface of PU catheters, so that it has water lubrication and antibacterial functions, but the storage stability of isocyanate-terminated prepolymers is a problem

Method used

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  • Application of polyurethane-based interpenetrating network polymer in surface modification of medical catheter
  • Application of polyurethane-based interpenetrating network polymer in surface modification of medical catheter
  • Application of polyurethane-based interpenetrating network polymer in surface modification of medical catheter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Step 1: Preparation of polyether type cross-linked polyurethane-1.

[0069] Add 25 kg of polyether diol DL-2000D with a mass average molecular weight of 2000 produced by Shandong Bluestar Dongda Chemical Co., Ltd. and 3.5 kg of trimethylolethane into the reaction kettle, and vacuum dry at 100°C to remove water for 2.5 hours , after which the material in the reactor was cooled to room temperature, N 2 Under protection and stirring, add 0.02 kg of dibutyltin dilaurate and 0.05 kg of triethylamine. After stirring evenly, continuously add a mixture of 30 kg of toluene diisocyanate (TDI80 / 20) and 30 kg of dehydrated acetone, and gradually increase the The temperature of the material is 60-65°C for 1 hour, and 70-80°C for 2 hours to prepare a viscous solution of polyether type cross-linked polyurethane-1 for later use.

[0070] Step 2: Preparation of functional polyurethane prepolymer-1

[0071] Add 20 kg of 6950F brand toluene isocyanate trimer with a solid content of abou...

Embodiment 2

[0078] Embodiment 2 Preparation of polyurethane-based interpenetrating network polymer-2

[0079] According to the method and operation steps of Example 1, the polyether diol DL-2000D with an average molecular weight of 2000 in Step 1 of Example 1 was replaced with hydroxyl-terminated polybutadiene diol-4000 (Shenzhen Hongyuan New Material Technology Co., Ltd.), the

[0080] Described trimethylolethane is changed into triethanolamine, and the quaternary ammonium cationic polyether glycol of structure shown in the formula (2-1) in embodiment 1 step 2 is changed into the quaternary ammonium cationic polyether glycol of structure shown in formula (2-2) Ammonium cationic polyether diols to prepare a viscous solution of polyurethane-based interpenetrating network polymer-2. Wherein the structure of the quaternary ammonium cationic polyether diol is shown in formula (2-2), and p+q in the formula (2-2) is equal to 20.

[0081]

Embodiment 3

[0082] Example 3 Preparation of Polyurethane-based Interpenetrating Network Polymer-3

[0083] According to the method and operating steps of Example 1, the polyether diol DL-2000D with the average molecular weight of 2000 in Step 1 of Example 1 was replaced with Polyethylene Glycol-4000 (Tianjin Zhonghe Shengtai Chemical Co., Ltd.), The quaternary ammonium cationic polyether diol of the structure shown in the formula (2-1) in the step 2 of embodiment 1 is changed into the quaternary ammonium cationic polyether diol of the structure shown in the formula (2-2), makes polyurethane base Viscous solution of interpenetrating network polymer-3. Wherein the structure of the quaternary ammonium cationic polyether diol is shown in formula (2-2), and p+q in the formula (2-2) is equal to 20.

[0084]

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Abstract

The invention provides an application of a polyurethane-based interpenetrating network polymer in surface modification of a medical catheter. The application comprises the following steps: respectively carrying out addition reaction on hydrophilic substances including hydroxyl-terminated polyethylene glycol alkyl ether, single hydroxyl-terminated polyvinylpyrrolidone and hydroxyl-terminated polyether quaternary ammonium salt and a polyisocyanate tripolymer to prepare a functional polyurethane prepolymer; and blending the functional polyurethane prepolymer with quaternary ammonium cationized dihydric alcohol with antibacterial and bactericidal functions, and carrying out step-by-step addition polymerization reaction to obtain the polyurethane-based interpenetrating network polymer which isused for surface hydrophilic antibacterial modification of medical catheters.

Description

technical field [0001] The invention relates to the application of polyurethane in the surface modification of medical catheters, in particular to the multifunctional polyurethane-based interpenetrating network polymerization of side chains hanging alkoxy polyethylene glycol chains, polyvinylpyrrolidone chains and quaternary ammonium cationic polyether chains The invention relates to the application of the substance in the modification of the surface of medical catheters for hydrophilic sterilization, and belongs to the field of functional polymer materials. Background technique [0002] As a commonly used diagnosis and treatment equipment, interventional catheters have been widely used in clinical treatment. According to reports, in 2015, about 5.7 billion catheters of various types were produced worldwide in different materials. With the widespread use of catheters, the requirements for catheter performance are also increasing. The materials currently used to make cathet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/62C08G18/50C08G18/48C08G18/12A61L29/08A61L29/16
CPCC08G18/4063C08G18/6283C08G18/482C08G18/5021C08G18/12A61L29/085A61L29/16A61L2300/404A61L2300/606A61L2300/208C08G18/6674C08G18/6677C08L75/04
Inventor 斯琴高娃于法港王正建陈星月张田林
Owner JIANGSU OCEAN UNIV
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