Preparation method and application of hollow mesoporous inorganic oxide nanosphere solid alkali

Abstract

The invention belongs to the field of heterogeneous catalysis, and discloses a preparation method of hollow mesoporous inorganic oxide nanosphere solid alkali, which comprises the following steps: adding nano colloidal carbon spheres into an inorganic metal salt solution/inorganic metal salt mixed solution, stirring, adsorbing, filtering, and washing to obtain a hollow mesoporous inorganic oxide carbon sphere precursor; drying the hollow mesoporous inorganic oxide carbon sphere precursor, grinding the dried hollow mesoporous inorganic oxide carbon sphere precursor into powder, and carrying outgradient heating calcination on the powder to obtain hollow mesoporous inorganic oxide nanosphere solid alkali. The invention also discloses an application of the hollow mesoporous inorganic oxide nanosphere solid base prepared by the preparation method. The hollow mesoporous inorganic oxide nanosphere solid base is used for catalyzing selective O-alkylation reaction of phenolic compounds. The hollow mesoporous inorganic oxide nanosphere solid alkali prepared by the method is uniform in particle size, proper in pore diameter and rich in porous structure, can be easily separated from a productafter catalyzing the selective O-alkylation reaction of phenolic compounds, and is convenient to recycle.

Description

technical field [0001] The invention belongs to the field of heterogeneous catalysis, and in particular relates to a preparation method and application of a hollow mesoporous inorganic oxide nanosphere solid base. Background technique [0002] O-alkylation products of phenolic compounds are widely used in pharmaceuticals, fine chemicals and petrochemicals. Among them, anisole can be used to prepare spices, pesticides, cosmetics and dyes, etc.; diphenol monoethers, such as 2-methoxyphenol, can be used to produce various fine chemicals and valuable synthetic intermediates; 3-methoxy Phenylphenol and 4-methoxyphenol can be used as UV inhibitors, oil antioxidants and polymerization inhibitors. Therefore, the selective synthesis of O-alkylated products of phenolic compounds is particularly important. [0003] The traditional method of O-alkylation of phenolic compounds has the following disadvantages: ①Stoichiometric strong base is required, such as Na 2 CO 3 、K 2 CO 3 , KO...

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Problems solved by technology

[0003] The traditional method of O-alkylation of phenolic compounds has the following disadvantages: ①Stoichiometric strong base is required, such as Na 2 CO 3 、K 2 CO 3 , KOH or NaOH to generate phenol anions, most of these inorganic bases cannot be miscible with organic raw materials, so toxic water-soluble solvents and phase transfer systems have to be used in the selection of reaction solvents, which cause separation problems

However, due to its inert reaction, it needs to be effectively carried out under the catalysis of high temperature and highly active solid base. The solid base reported in the literature can only realize the selective O-alkylation of phenolic compounds under the condition of more than 300 °C. The highest selectivity of O-alkylated products is only 84%, and C-alkylated by-products are inevitably generated

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