Preparation method and application of porous material assembled by graphene oxide and chitosan molecules

A porous material, chitosan technology, used in applications, bandages, surgery, etc., can solve the problems of poor mechanical strength, poor mechanical strength of sponges, inability to exert coagulation effect, etc., and achieve excellent antibacterial properties and improve the effect of coagulation performance.

Active Publication Date: 2021-02-05
FANGDA CARBON NEW MATERIAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in practical applications, chitosan sponges prepared directly from chitosan have poor mechanical strength.
The patent application number 201210545888.8 discloses a porous hemostatic sponge made of

Method used

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  • Preparation method and application of porous material assembled by graphene oxide and chitosan molecules

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Embodiment 1

[0028] A preparation method of a porous material based on graphene oxide and chitosan molecular assembly, specifically comprising the following steps:

[0029] Step 1, taking 2g of chitosan with a degree of deacetylation of 96.2% is dispersed in 80mL of deionized water at a stirring speed of 200rppm, and stirred for 8min to obtain an aqueous dispersion of chitosan;

[0030] Step 2: Take 20 mL of graphene oxide aqueous solution with a concentration of 10 mg / mL, and add it to the chitosan aqueous dispersion under continuous stirring. After 10 minutes, add 10 μL of glutaraldehyde as a cross-linking agent, and continue to heat at 15 ° C, 300 rpm Under the condition of stirring 50min, obtain cross-linked graphene oxide-chitosan aqueous dispersion;

[0031] Step 3: Add 1 mL of glacial acetic acid into the cross-linked graphene oxide-chitosan aqueous dispersion, and continue stirring for 10 h at 25° C. and 1000 rpm to obtain a uniform cross-linked graphene oxide-chitosan solution, fr...

Embodiment 2

[0033] A preparation method of a porous material based on graphene oxide and chitosan molecular assembly, specifically comprising the following steps:

[0034]Step 1, taking 3g of chitosan with a degree of deacetylation of 96.5% is dispersed in 80mL of deionized water at a stirring speed of 300rppm, and stirred for 8min to obtain an aqueous dispersion of chitosan;

[0035] Step 2: Take 20 mL of graphene oxide aqueous solution with a concentration of 5 mg / mL, and add it to the chitosan water dispersion under continuous stirring. After 10 minutes, add 100 μL of glyoxal as a cross-linking agent, and continue at 35 ° C, 100 rpm Under the condition of stirring 40min, obtain cross-linked graphene oxide-chitosan aqueous dispersion;

[0036] Step 3: Add 2 mL of oxalic acid into the cross-linked graphene oxide-chitosan aqueous dispersion, and continue stirring for 5 hours at 45° C. and 1200 rpm to obtain a uniform cross-linked graphene oxide-chitosan solution, freeze-dry, and obtain S...

Embodiment 3

[0038] A preparation method of a porous material based on graphene oxide and chitosan molecular assembly, specifically comprising the following steps:

[0039] Step 1, taking 2g of chitosan with a degree of deacetylation of 86.5% is dispersed in 80mL of deionized water at a stirring speed of 200rppm, and stirred for 8min to obtain an aqueous dispersion of chitosan;

[0040] Step 2: Take 20 mL of graphene oxide aqueous solution with a concentration of 5 mg / mL, and add it to the chitosan water dispersion under continuous stirring. After 10 minutes, add 50 μL of formaldehyde as a cross-linking agent, and continue at 25 ° C and 200 rpm. Down stirring 30min, obtains cross-linked graphene oxide-chitosan aqueous dispersion;

[0041] Step 3: Add 2 mL of concentrated hydrochloric acid into the cross-linked graphene oxide-chitosan aqueous dispersion, and continue stirring for 24 hours at 35° C. and 500 rpm to obtain a uniform cross-linked graphene oxide-chitosan solution, freeze-dry, A...

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Abstract

The invention discloses a porous material based on graphene oxide and chitosan molecule assembly, and also discloses a preparation method of the porous material based on graphene oxide and chitosan molecule assembly, which comprises the following steps: adding a graphene oxide aqueous solution into a chitosan aqueous dispersion, carrying out interface self-assembly, adding a cross-linking agent, adding an acid solution for treatment, and performing freeze drying to obtain the porous material of the cross-linked graphene oxide chitosan. The hemostatic material is prepared by crosslinking and compounding the graphene and the chitosan by using the crosslinking agent, so that the mechanical strength of chitosan macromolecules is improved, and the hemostatic performance and the antibacterial effect of the hemostatic material are also improved.

Description

technical field [0001] The invention relates to the technical field of composite materials. More specifically, the present invention relates to the preparation and application of a porous material assembled with graphene oxide and chitosan molecules. Background technique [0002] Excessive blood loss caused by traumatic hemorrhage is an important cause of death and disability in wartime and clinically. Rapid hemostasis is one of the key measures to treat the disabled in war wound treatment and clinical treatment. The hemostatic material mainly prevents the flow of blood by forming a certain barrier to achieve the purpose of hemostasis. A good hemostatic material can not only effectively stop bleeding, but also protect the wound from contamination and infection by dust particles, bacteria and viruses, provide a good healing environment for the wound, and promote the rapid healing of the wound. The development of a hemostatic material that can quickly stop bleeding, prevent...

Claims

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Application Information

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IPC IPC(8): C08J9/28C08L5/08C08K3/04C08K5/07A61L24/08A61L15/42
CPCC08J9/28A61L24/08A61L15/425C08J2305/08C08J2201/0484C08K3/042C08L5/08
Inventor 拜永孝金丽君党锡江张桂兰
Owner FANGDA CARBON NEW MATERIAL CO LTD
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