Strychnine gel preparation and preparation method thereof

A gel preparation, strychnine technology, applied in the directions of anti-inflammatory agents, pharmaceutical formulations, aerosol delivery, etc., can solve the problems of stratum corneum damage, high lipophilicity, skin damage, etc. Spreading, good biocompatibility

Pending Publication Date: 2021-02-23
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Azone has a strong skin penetration-promoting effect, but due to its high lipophilicity, azone will accumulate in the skin for a long time, destroy the stratum corneum, and cause irreversible skin damage, which is very irritating

Method used

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  • Strychnine gel preparation and preparation method thereof
  • Strychnine gel preparation and preparation method thereof
  • Strychnine gel preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] formula Dosage (g) strychnine 10.0 carbomer 8.3 Absolute ethanol 166.7 Propylene Glycol 250.0 5M NaOH 0.05 Ethylenediaminetetraacetic acid 0.83 Ethylparaben 1.67 water 1230.0

[0027] Preparation:

[0028] (1) Add 8.3g of carbomer into water to swell completely, adjust the pH value to about 6 with 5M sodium hydroxide to obtain gel matrix I; (2) dissolve 1.67g of ethylparaben in propylene glycol to obtain solution a, 0.83 g ethylenediaminetetraacetic acid is dissolved in an appropriate amount of water to obtain solution b, 10g strychnine is dissolved in absolute ethanol and solution a to obtain solution c, and solution c and b are mixed uniformly to obtain strychnine solution II; (3) condensation Gum base I is mixed with strychnine solution II and stirred evenly to obtain a strychnine gel preparation.

Embodiment 2

[0030] formula Dosage (g) strychnine 10.0 Hydroxypropylmethylcellulose 33.33 Absolute ethanol 250.0 Propylene Glycol 250.0 0.1M citric acid 0.08 Ethylenediaminetetraacetic acid 0.83 Ethylparaben 1.67 water 1120.0

[0031] Preparation:

[0032] (1) Add 33.33g of hydroxypropyl methylcellulose into water to swell completely to obtain gel matrix I; (2) dissolve 1.67g of ethylparaben in propylene glycol to obtain solution a, and dissolve 0.83g of ethylenediaminetetraacetic acid in Appropriate amount of water is obtained solution b, 10.0g strychnine is dissolved in absolute ethanol and solution a to obtain solution c, solution c and b are mixed uniformly to obtain strychnine solution II; (3) gel matrix I and strychnine Alkaline solution II was mixed, stirred evenly, and 0.1M citric acid was added to adjust the pH value to about 7 to obtain a strychnine gel preparation.

Embodiment 3

[0034] formula Dosage (g) strychnine 10.0 Hydroxypropylmethylcellulose 40.0 Absolute ethanol 200.0 Propylene Glycol 300.0 0.1M citric acid 0.10 water 1450.0

[0035] Preparation:

[0036] (1) Add 40 g of hydroxypropyl methylcellulose to water to swell completely to obtain gel matrix I; (2) dissolve 10 g of strychnine in absolute ethanol and propylene glycol, mix with the remaining prescription amount of water, and stir evenly to obtain strychnine Subalkali solution II; (3) Gel matrix I was mixed with strychnine solution II, stirred evenly, and 0.1M citric acid was added to adjust the pH value to about 7 to obtain a strychnine gel preparation.

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a strychnine gel preparation and a preparation method thereof. The gel preparation comprises 0.5%-1% of strychnine, 0.5%-3% of a gel skeleton, 10%-30% of a cosolvent and the balance of water. According to the prepared strychnine hydrogel, simple pharmaceutic adjuvants are used, no transdermal enhancer isused, but the transdermal effect is excellent, and the strychnine hydrogel is easy to spread, good in biocompatibility, good in skin absorption, good in drug membrane adhesiveness and free of irritation to skin and mucous membranes.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a strychnine gel preparation and a preparation method thereof. Background technique [0002] Knee osteoarthritis is a disease based on degenerative pathological changes. When knee osteoarthritis attacks, the pain is severe, and the pain is localized and deep. Drugs are needed to quickly reach the disease. site, and long-lasting effect. [0003] Nuxynum is bitter and warm in nature; it is very poisonous. It has the effects of dredging collaterals and relieving pain, dissipating stagnation and detumescence. For bruises, fracture swelling and pain, rheumatic obstinate numbness, numbness and paralysis etc. The main active ingredients of Nuxychnium are total alkaloids, which include strychnine, strychnine, strychnine, strychnine, strychnine, ecaine, etc.; Alkali has anti-inflammatory and analgesic effects; strychnine basically has no anti-inflammatory and ana...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/38A61K47/36A61K47/42A61K47/32A61K31/475A61P19/02A61P29/00
CPCA61K9/06A61K9/0014A61K47/38A61K47/36A61K47/42A61K47/32A61K31/475A61P19/02A61P29/00A61K47/10
Inventor 张保献胡杰吴珍珍赵倩薛春美李文慧曹瑛
Owner BEIJING INCREASEPHARM CORP LTD
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