Preparation method of biomedical metal material loaded with multifunctional composite coating

A composite coating, biomedical technology, applied in the field of preparation of biomedical metal materials, can solve the problems of limited application, difficult combination, easy corrosion, etc., and achieve favorable growth and adhesion, good biocompatibility, and improved corrosion resistance. Effect

Inactive Publication Date: 2021-03-16
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the inertness of the metal material itself, the repair performance of the induced tissue on the surface of the material will be poor, and it is difficult to form a firm combination with the tissue.
In addition, for implants, blood components or cell metabolism can easily lead to the formation of thrombus on the material surface
Furthermore, for magnesium alloys, it is easy to corrode in the physiological environment of the human body, resulting in poor performance in the body, which limits its application.

Method used

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  • Preparation method of biomedical metal material loaded with multifunctional composite coating
  • Preparation method of biomedical metal material loaded with multifunctional composite coating
  • Preparation method of biomedical metal material loaded with multifunctional composite coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Choose Ti6Al4V titanium alloy, after grinding and polishing, immerse it in hydrofluoric acid solution, then take it out, wash it with acetone, ethanol and deionized water respectively, take it out and dry it, and immerse the sample in 0.05mg / ml polyethyleneimine solution Leave it for a period of time, take it out and dry it for later use. Preparation mass fraction is 10% regenerated silk fibroin (RSF) aqueous solution, concentration is the chitosan (CS) solution of 5mg / ml and the gelatin aqueous solution (GEL aqueous solution) of mass fraction 5%: Utilize sodium carbonate (Na 2 CO 3 ) aqueous solution to degumming the silk, dissolving the degummed silk in lithium bromide aqueous solution, centrifuging, filtering and dialysis to obtain regenerated silk fibroin aqueous solution, and concentrating it to 10% by mass. Take a certain amount of chitosan and dissolve it in 2vol.% acetic acid aqueous solution to prepare a chitosan solution with a concentration of 5 mg / ml. Diss...

Embodiment 2

[0031] Choose AZ31B magnesium alloy, after grinding and polishing, dip it in hydrofluoric acid solution, then take it out, wash it with acetone, ethanol and deionized water respectively, take it out and dry it, and dip the sample in 10mg / ml polyethyleneimine solution After a period of time, take it out and dry it for later use. Prepare the RSF aqueous solution that the mass fraction is 15%, the CS solution that the concentration is 15mg / ml and the GEL solution of mass fraction 8%: Utilize sodium carbonate (Na 2 CO 3 ) aqueous solution to degumming the silk, dissolving the degummed silk in lithium bromide aqueous solution, centrifuging, filtering and dialysis to obtain regenerated silk fibroin aqueous solution, and concentrating it to 15% by mass. Take a certain amount of chitosan and dissolve it in 2vol.% acetic acid aqueous solution to prepare a chitosan solution with a concentration of 15mg / ml. Take a certain amount of gelatin and dissolve it in water to prepare an 8% gela...

Embodiment 3

[0033] Select stainless steel, after grinding and polishing, immerse it in hydrofluoric acid solution, then take it out, wash it with acetone, ethanol and deionized water respectively, take it out and dry it, and immerse the sample in 40mg / ml polyethyleneimine solution for a period of time , take out and dry for later use. Preparation mass fraction is 20% RSF aqueous solution, concentration is the CS solution of 25mg / ml and the GEL solution of mass fraction 10%: Utilize sodium carbonate (Na 2 CO 3 ) aqueous solution to degumming the silk, dissolving the degummed silk in lithium bromide aqueous solution, centrifuging, filtering and dialysis to obtain regenerated silk fibroin aqueous solution, and concentrating it to 20% by mass. Take a certain amount of chitosan and dissolve it in 2vol.% acetic acid aqueous solution to prepare a chitosan solution with a concentration of 25mg / ml. Take a certain amount of gelatin and dissolve it in water to prepare a 10% gelatin aqueous solutio...

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Abstract

The invention relates to a preparation method of a biomedical metal material loaded with a multifunctional composite coating, and belongs to the technical field of membrane material preparation. The biomedical metal material is composed of a matrix metal material and a silk fibroin / chitosan / gelatin composite fiber coating loaded on the surface of the matrix metal material. The preparation method comprises the following steps of 1) pretreating the surface of the matrix metal material; 2) preparing a mixed solution of silk fibroin, chitosan and gelatin; 3) preparing a mixed solution containing growth factors and anticoagulant or antibacterial and anti-inflammatory drugs; 4) spinning silk fibroin / chitosan / gelatin composite fibers loaded with the cell growth promoting factors and the anticoagulant or antibacterial and anti-inflammatory drugs on the surface of metal by utilizing electrostatic spinning through mixed spinning and coaxial spinning; and 5) treating the composite coating with high-humidity treatment. The biomedical metal loaded with the multifunctional composite coating prepared by the invention has good biocompatibility and antibacterial property, also has the functions ofslowly releasing drugs, inhibiting thrombosis and the like, and has a good application prospect clinically.

Description

technical field [0001] The invention relates to the fields of membrane material preparation and biomedical materials, in particular to a method for preparing a biomedical metal material loaded with a multifunctional composite coating. Background technique [0002] For human hard tissue (such as bones, teeth and joints, etc.) repair implant materials, it has a wide demand in surgical clinics. Biomedical metal materials, such as titanium alloys and magnesium alloys, have excellent strength and processing technology, so they are often used to prepare materials for artificial bones or joints. However, due to the inertness of the metal material itself, the repair performance of the induced tissue on the surface of the material will be poor, and it is difficult to form a firm combination with the tissue. In addition, for implants, blood components or cell metabolism can easily lead to the formation of thrombus on the material surface. Furthermore, for magnesium alloys, it is eas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/06A61L27/28A61L27/34A61L27/50A61L27/54A61L27/58D01D5/00D01D5/34
CPCA61L27/06A61L27/047A61L27/34A61L27/28A61L27/58A61L27/54A61L27/50D01D5/0084D01D5/0015D01D5/34A61L2300/414A61L2300/42A61L2300/404A61L2300/41A61L2300/406A61L2300/604A61L2300/606A61L2400/18A61L2420/02
Inventor 张超王心如叶玮刘爱辉刘静静柳森周志承
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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