A method for detecting the content of various components in Ammeguasu oral solution by HPLC method

A technology for oral solution and content, which is used in measurement devices, material separation, and analysis of materials, etc., can solve problems such as inaccurate measurement results, and achieve the effects of fast analysis, improved tailing, and prevention of damage.

Active Publication Date: 2021-09-28
SICHUAN FENGCHUN PHARMA
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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for detecting the content of various components in the aminomeguasu oral solution by using the HPLC method, so as to solve the problem of inaccurate measurement results caused by the existing method of simultaneously measuring multiple components in the aminomeguasu compound preparation

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  • A method for detecting the content of various components in Ammeguasu oral solution by HPLC method
  • A method for detecting the content of various components in Ammeguasu oral solution by HPLC method
  • A method for detecting the content of various components in Ammeguasu oral solution by HPLC method

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Embodiment

[0039]1. Chromatographic conditions and system suitability test: use octadecylsilane bonded silica gel as a filler (ACE ExcelC18, 4.6mm×250mm, 5μm) chromatographic column; use phosphate buffer solution (containing sodium dihydrogen phosphate 30mmol / L , sodium octane sulfonate 2.50g / L, adjust pH to 3.0 with phosphoric acid)-methanol (90:10) is mobile phase A, with above-mentioned phosphate buffer solution-acetonitrile (25:75) as mobile phase B, according to the table 1 Carry out gradient elution, the flow rate is 1.0ml per minute, the column temperature is 30°C, and the detection wavelength is 220nm.

[0040] Table 1 Gradient elution

[0041]

[0042] 2. Preparation of the reference substance solution: Take an appropriate amount of paracetamol, dextromethorphan hydrobromide, guaiacol glyceryl ether, phenylephrine hydrochloride, sodium benzoate, and pepropropyl ester, weigh them accurately, and use mobile phase A Dissolve and quantitatively dilute to make about 325.0 μg of p...

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Abstract

The invention discloses a method for detecting the content of various components in the oral solution of Ammeguasu by HPLC. The chromatographic conditions of the HPLC method are as follows: octadecylsilane bonded silica gel is used as filler, and phosphate The mixture of buffer solution and methanol is mobile phase A, the mixture of phosphate buffer solution and acetonitrile is mobile phase B for gradient elution, the flow rate is 0.5-1.5ml per minute, the column temperature is 25-40°C, and the detection wavelength 200‑254nm. The present invention can not only detect acetaminophen, dextromethorphan hydrobromide, guaiacol glyceryl ether, phenylephrine hydrochloride, sodium benzoate and peproterate in the oral solution of Ammegualine simultaneously, but also have a common peak among them All components are identified, have good reproducibility and high accuracy, and are suitable for the quality control of the active component content of the ammeguabu oral solution of the present invention.

Description

technical field [0001] The invention relates to the technical field of drug analysis, in particular to a method for detecting the contents of various components in ammeguabu oral solution by HPLC. Background technique [0002] Ammegualine Oral Solution is composed of active ingredients acetaminophen, dextromethorphan hydrobromide, guaiacol glyceryl ether, phenylephrine hydrochloride and a certain amount of inactive ingredients such as solubilizers, flavoring agents, preservatives It is composed of auxiliary materials such as anti-oxidant, antioxidant, oxygen-promoting agent, PH regulator, etc. It is a medicine for treating children with multi-symptom cold and fever. It can treat and relieve common cold and flu symptoms, such as nasal congestion, cough and mild throat and bronchial inflammation The intensity of the urge to cough can treat and relieve minor aches, headaches, sore throats, temporarily reduce fever, and help loosen the flow of phlegm (mucus) and bronchiolar secr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8679
Inventor 何德中杜鸿儒曲韵智钟茂团钟小莉刘亚
Owner SICHUAN FENGCHUN PHARMA
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