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PEEK bone repair material and surface modification method and application thereof

A technology for surface modification and bone repair, which is applied in the fields of pharmaceutical formulation, medical science, tissue regeneration, etc. It can solve the problems of poor performance such as cell adhesion, hydrophilicity, and cell differentiation, and achieve improved hydrophilicity and hydrophilicity. enhanced effect

Inactive Publication Date: 2021-03-23
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention provides a PEEK bone repair material in order to overcome the biological activity of the surface-modified PEEK bone repair material in the prior art, such as poor cell adhesion, hydrophilicity and cell differentiation. Materials and their surface modification methods and applications

Method used

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  • PEEK bone repair material and surface modification method and application thereof
  • PEEK bone repair material and surface modification method and application thereof
  • PEEK bone repair material and surface modification method and application thereof

Examples

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Embodiment 1

[0050] The PEEK powder is the PEEK of model 450G commercially available from Victrex Company, UK.

[0051] A certain amount of PEEK (450G, Victrex, UK) powder was weighed, soaked in acetone for 24 h, rinsed with deionized water several times, and dried at 60 °C for 4 h. PEEK powder was placed in a custom-made mold (Φ10×2mm), and pressed using a tablet press (YP-15T, Jinfulun Technology Co., Ltd, China) at a pressure of 6MPa for 1min, and then the preliminarily formed samples were collected Put it in a muffle furnace, raise the temperature to 345°C for 2h, and keep it warm for 2h to collect the sintered samples. After polishing with sandpaper, use absolute ethanol and deionized water to ultrasonically clean them several times, and dry them at 80°C to obtain the modified Sexual PEEK.

[0052] A femtosecond laser (GLX-200HP-1053, Time-Bandwidth Products AG, Switzerland, FL for short) was used to perform planar scanning ablation on the prepared PEEK to be modified above at differ...

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Abstract

The invention discloses a PEEK bone repair material and a surface modification method and application thereof. The surface modification method of the PEEK bone repair material comprises the followingsteps that femtosecond laser ablation is conducted on the surface of PEEK to be modified, and the surface-modified PEEK bone repair material is obtained; in the femtosecond laser ablation process, thelaser power is 40-160mW; and femtosecond laser ablation is plane scanning ablation conducted on the surface of PEEK to be modified. The PEEK bone repair material is in a micro-nano morphology, has excellent hydrophilicity and surface roughness and can promote cell adhesion, proliferation and cell differentiation.

Description

technical field [0001] The invention relates to a PEEK bone repair material and its surface modification method and application. Background technique [0002] Polyetheretherketone (PEEK) is a polyaryletherketone polymer whose main chain structure is composed of benzene rings, ketone bonds and ether bonds. It was developed and produced in the UK in the 1980s. In the field of orthopedics, PEEK, as an artificial bone repair material for bone repair and replacement, is considered to be the preferred biomaterial to replace traditional metal implants (such as titanium and its alloys and other metal alloys), and has gradually become a traditional metal and other metal alloy in various fields. Substitutes for ceramic materials have been developed and applied. [0003] However, PEEK is biologically inert and hydrophobic, lacks biological activity, and cannot be well osseointegrated with the host bone after implantation, so it needs to be surface modified to improve biological activi...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/50A61L27/56
CPCA61L27/18A61L27/50A61L27/56A61L2400/18A61L2430/02C08L61/16
Inventor 魏杰杨立利梅师奇钱军赵君仝艳芳丁超宋思勤邓晨
Owner EAST CHINA UNIV OF SCI & TECH
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