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Preparation method of adsorbent for removing LDL through extracorporeal circulation of blood and perfusion device

An adsorbent and external circulation technology, which is applied in the field of perfusion devices, can solve the problems that quinoline has irritating odor, affects product safety, and prolongs reaction time, so as to shorten reaction time, facilitate collection or recycling, and react short cycle effect

Active Publication Date: 2021-03-30
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The condensing agent EEDQ is very unstable and needs to be stored and transported at 2°C to 8°C. It is prone to decomposition and becomes invalid when the temperature rises. In order to maintain the activity of EEDQ during the reaction, both US5476715A and CN109248668A set the reaction temperature to room temperature. Using a relatively low reaction temperature, the reaction time is extended to more than 12 hours, and the reaction speed is slow
EEDQ and its decomposed products are insoluble in water and most organic solvents, and are not easy to remove from LDL adsorbents. Residues in the product affect the safety of the product. By-products such as quinoline also have a pungent odor.
Moreover, the reaction usually requires an excess of EEDQ to promote the reaction, and the excess condensing agent will also directly remain

Method used

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  • Preparation method of adsorbent for removing LDL through extracorporeal circulation of blood and perfusion device
  • Preparation method of adsorbent for removing LDL through extracorporeal circulation of blood and perfusion device
  • Preparation method of adsorbent for removing LDL through extracorporeal circulation of blood and perfusion device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The present embodiment adopts following steps to prepare adsorbent:

[0037] Step 1: The carrier resin containing epoxy groups is subjected to a ring-opening reaction with an amine. Specifically: take 20 mL of polyglycidyl methacrylate resin, mix it with an aminating agent, stir and react at 50° C. for 1.5 h, and make the epoxy group on the carrier resin undergo a ring-opening reaction. Among them, the volume ratio of polyglycidyl methacrylate resin to the aminating agent is 1: (1-5); the aminating agent is a mixture of lower amines (including ethylenediamine, etc.) The volume ratio is 1:(1-3); after the ring-opening reaction, the obtained resin is washed with water until the effluent is neutral.

[0038] Step 2: reacting the product of step 1 with epichlorohydrin to graft hydrocarbyl chloride. Specifically: add a mixture of 10 mL of epichlorohydrin and 20 mL of water to the resin obtained in step 1, stir and react at 45°C for 3 hours, so that the carrier resin has a ...

Embodiment 2

[0045] The present embodiment adopts following steps to prepare adsorbent:

[0046] Step 1: Ring-opening reaction with amine after epoxidation of cellulose carrier. Specifically: take 20mL of cellulose balls, use epichlorohydrin or 1,4-butanediol diglycidyl ether for epoxidation, control the pH to 8-11, stir and react at 30°C for 3 hours, and obtain the epoxidized Carrier. After the carrier is washed, it is mixed with an aminating agent, stirred and reacted at 50° C. for 1.5 h, so that the ring-opening reaction of the epoxy group on the carrier occurs. Among them, the volume ratio of the carrier to the aminating agent is 1: (1 to 5); the aminating agent is a mixture of lower amines (including ammonia, ethylenediamine, etc.) and water, and the volume ratio of the lower amines to water is 1:( 1-3); after the ring-opening reaction is completed, the obtained product is washed with water until the effluent is neutral.

[0047] Step 2: reacting the product of step 1 with epichlor...

Embodiment 3

[0054] The present embodiment adopts the chlorination reaction process route different from embodiment 1 to prepare adsorbent, comprises the following steps:

[0055] Step 1: Take 20mL of polyglycidyl methacrylate resin, add 2mL of concentrated hydrochloric acid and 80mL of acetone mixture, stir and react at 45°C for 3h, so that the epoxy groups on the carrier resin undergo a ring-opening reaction to obtain Carriers with hydrocarbyl chloride groups, the obtained resin is washed with water until the effluent is neutral.

[0056] Step 2: The product of step 1 is subjected to an acid hydrolysis reaction with polyacrylic acid to obtain an adsorbent. For parameters such as reaction conditions, refer to Step 3 of Example 1. Specifically, 20 mL of polyacrylic acid aqueous solution was added to the product obtained in Step 1, and stirred and reacted at 45° C. for 4 h to obtain an adsorbent. Among them, the mass ratio of polyacrylic acid to water is 1.5:5; the pH of the solution is ad...

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Abstract

The invention relates to a preparation method of an adsorbent for removing LDL through extracorporeal circulation of blood and a perfusion apparatus, and the preparation method comprises the followingsteps: step 1, carrying out ring-opening reaction on a carrier containing amino and a halogenated epoxy compound to obtain an intermediate product containing halogenated hydrocarbon; and 2, carryingout an acidolysis reaction on the intermediate product and polyanions to obtain the adsorbent. According to the preparation method, the production efficiency can be improved, and the product safety can be improved.

Description

technical field [0001] The invention relates to the technical field of extracorporeal blood purification, and specifically includes an adsorbent capable of removing low-density lipoprotein, total cholesterol and triglyceride in blood extracorporeal circulation, a preparation method thereof, and a perfusion device. Background technique [0002] Lipid metabolism disorder is an important factor that causes atherosclerosis and subsequently cardiovascular and cerebrovascular diseases. Epidemiological investigations have been confirmed. [0003] Active lipid-lowering therapy plays an important role in cardiovascular and cerebrovascular diseases. The vast majority of patients with lipid metabolism disorders can control the disease well through active diet control, appropriate physical activity and appropriate lipid-lowering drugs, but patients with congenital homozygous familial hypercholesterolemia need to be treated regularly. Lipid-lowering treatment, otherwise coronary heart ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30A61M1/36
CPCB01J20/265B01J20/3085A61M1/3621
Inventor 董凡谢煜
Owner JAFRON BIOMEDICAL
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