Application of USP4 as autoimmune liver disease biomarker

A technology of autoimmunity and markers, applied in the field of medical testing, can solve problems such as limited means and unclear results, and achieve the effect of obvious technical effect and important clinical application value
CN112646880APending Publication Date: 2021-04-13THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
Publication Date
2021-04-13

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Abstract

The invention discloses an application of USP4 as an autoimmune liver disease biomarker, and belongs to the field of medical detection. USP4 is applied to preparation of the autoimmune liver disease marker. The USP4 is also applied to preparation of a fluorescent quantitative detection kit for diagnosing or predicting the autoimmune liver disease, and the kit is used for detecting the expression level of the USP4 in peripheral blood mononuclear cells. Experiments prove for the first time that the expression level of USP4 in peripheral blood mononuclear cells of patients with autoimmune liver diseases is significantly increased compared with the expression level of USP4 in healthy subjects. The USP4 expression quantity in the peripheral blood provided by the invention is used as a molecular marker, so that noninvasive detection can be carried out on the autoimmune liver disease, noninvasive dynamic monitoring can be carried out, and the kit has important clinical application value.
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Description

technical field

[0001] The invention relates to the field of medical detection, in particular to the application of USP4 as a biomarker for autoimmune liver disease. Background technique

[0002] Autoimmune liver disease (AILD) is a group of chronic inflammatory diseases of the hepatobiliary system mediated by autoimmune reactions, mainly involving liver damage, mainly including primary biliary cirrhosis (primary biliary cirrhosis, PBC), autoimmune hepatitis (autoimmune hepatitis, AIH) and primary sclerosing cholangitis (primary sclerosing cholangitis, PSC), etc. There is no clear clinical standard for the diagnosis of autoimmune liver disease. However, if the disease is not controlled, it can lead to progressive liver fibrosis and cirrhosis after long-term development. Therefore, early diagnosis of autoimmune liver disease is very necessary.

[0003] Deubiquitination is a reversible process of ubiquitination by the removal of ubiquitin protein groups by deubiquitinating e...

Claims

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