Visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and preparation method thereof

A healing hydrogel and photocatalytic technology, applied in medical science, bandages, etc., can solve the problems of tissue damage, no reduction in infection, etc., achieve the effect of simple method, reduce bacterial infection, and promote wound healing

Pending Publication Date: 2021-04-16
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional medical dressings, such as absorbent cotton gauze, gauze strips, cotton balls, and cotton membranes, are clinically used to protect wounds and have the function of p

Method used

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  • Visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and preparation method thereof
  • Visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and preparation method thereof
  • Visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034]Example 1:

[0035]It is weighed 20 mg collagen in a 2 ml of 1% acetic acid solution, and thoroughly stirred it to dissolve, and then the pH was adjacent to neutral sodium hydroxide solution, and the collagen solution was obtained. It is weighted 40 mg of alginate sodium alginate in 2 ml of deionized water, thoroughly stirring to dissolve, and sodium alginate solution. Under stirring, the alginate solution is added to the collagen solution, thoroughly stirred, and the collagen-alginate solution is obtained. The graphite phase breened carbon nanchi was dispersed in deionized water, and 30 min was tested for 30 min, and a uniform 0.6 mg / ml graphite phase nitrocarbon nano-dispersion was dispersed, and 1 ml of carbon nitride nano sheet dispersion and collagen-alginate Solution mixing (graphite phase nitrocarbon nanofin is used as 1% of collagen and the total mass of sodium alginate), stirring at normal temperature for 2 h, centrifugation, inserted into the mold, stand, add 6ml 1 wt...

Example Embodiment

[0036]Example 2:

[0037]It is weighed 20 mg collagen in a 2 ml of 1% acetic acid solution, and thoroughly stirred it to dissolve, and then the pH was adjacent to neutral sodium hydroxide solution, and the collagen solution was obtained. It is weighted 40 mg of alginate sodium alginate in 2 ml of deionized water, thoroughly stirring to dissolve, and sodium alginate solution. Under stirring, the alginate solution is added to the collagen solution, thoroughly stirred, and the collagen-alginate solution is obtained. The graphite phase-propelled carbon nanchi was dispersed in deionized water, and 30 min was tested for 30 min. Solution mixing (graphite phase nitrocarbon nanofer is used as 2% of collagen and the total mass of sodium alginate), stirring at normal temperature for 2 h, centrifugation, pour into the mold, stand, add 6ml 1 wt% CaCl2The solution crosslinked for 1 h, and then washed three-time visible light response to the photocatalytic antibacterial initiaturized hydrophilic gel ...

Example Embodiment

[0038]Example 3:

[0039]It is weighed 20 mg collagen in a 2 ml of 1% acetic acid solution, and thoroughly stirred it to dissolve, and then the pH was adjacent to neutral sodium hydroxide solution, and the collagen solution was obtained. It is weighted 40 mg of alginate sodium alginate in 2 ml of deionized water, thoroughly stirring to dissolve, and sodium alginate solution. Under stirring, the alginate solution is added to the collagen solution, thoroughly stirred, and the collagen-alginate solution is obtained. The graphite phase breened carbon nanchi was dispersed in deionized water, and 30 min was tested for 30 min. Solution mixing (graphite phase breened carbon nanofer is used as 3% of collagen and the total mass of sodium alginate), stirring at normal temperature for 2 h, centrifugation, inserted into the mold, stand, add 6 ml 1 wt% CaCl2The solution crosslinked for 1 h, and then washed three-time visible light response to the photocatalytic antibacterial initiaturized hydrophili...

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Abstract

The invention discloses visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: preparing bulk-phase graphite-phase carbon nitride by taking melamine as a raw material, and stripping the bulk-phase graphite-phase carbon nitride into ultrathin carbon nitride nanosheets by adopting acid etching and ultrasonic treatment; then mixing the prepared carbon nitride nanosheet dispersion liquid with a collagen sodium alginate solution to obtain a gel precursor; and crosslinking the gel precursor by using a calcium chloride solution to obtain the visible-light-responsive photocatalytic antibacterial healing-promoting hydrogel. The hydrogel prepared by the preparation method not only has an excellent photocatalytic antibacterial effect in response to visible light, but also has good biocompatibility and swelling property, and can absorb redundant tissue fluid to provide a wet environment for wound repair, so that the effect of promoting wound healing is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a visible light-responsive photocatalytic antibacterial and healing-promoting hydrogel and a preparation method thereof. Background technique [0002] Wound healing is often accompanied by bacterial infection, which usually requires treatment with antibiotics. However, overuse of antibiotics can lead to the development of drug resistance and superbugs, which can also lead to side effects that damage the immune system. Although some inorganic antibacterial drugs and organic antibacterial agents have broad-spectrum antibacterial ability, most of them are toxic in vivo and act slowly. [0003] The main function of medical dressings is to cover and protect damaged skin and provide an environment conducive to wound healing. Traditional medical dressings, such as absorbent cotton gauze, gauze strips, cotton balls, and cotton membranes, are clinically used to ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24A61L26/00C08L5/04C08L89/00C08K3/28
Inventor 陈敬华张慧杰叶宝婷
Owner JIANGNAN UNIV
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