153results about How to "Moderate and controllable conditions" patented technology

The invention belongs to the field of pharmaceutical agents, relates to a polymer micelle lyophilized agent encapsulating an insoluble antitumor drug as well as a preparation method and an application thereof. The polymer micelle lyophilized agent is prepared by carrying out molecular self-assembly on a methoxy poly(ethylene glycol) 2000-polyester block copolymer to form micelles, and then encapsulating the insoluble antitumor drug in a hydrophobic core formed by the polyester. The lyophilized agent has high encapsulation rate, high drug loading and small particle size, can significantly improve the water solubility of the insoluble drug and result in passive targeting of more antitumor drugs to concentrate in the tumor tissues, thus improving an anti-tumor treatment effect and reducing the toxic and side effects of drugs, and can be used to prepare the drugs used for the treatment of lung cancer, intestinal cancer, mammary cancer, ovarian cancer, etc. The lyophilized agent can also be quickly dissolved and dispersed to form a transparent micellar solution after water for injection, normal saline solution and the like are added, and is used for the preparation of the drugs for treating primary intestinal cell carcinoma.

The invention discloses a heat resistance and salt tolerance polymer filtrate reducer. The heat resistance and salt tolerance polymer filtrate reducer is prepared from 1% to 3% of sodium carboxymethylcellulose, 5% to 12% of 2-acrylamide-2-methyl propane sulfonic acid, 10% to 40% of sodium acrylate, 0.2% to 0.5% of initiator and 0.01% to 0.03% of cross-linking agent in percentages by weight in an aqueous solution, wherein the initiator is ammonium persulfate or potassium peroxodisulfate; and the cross-linking agent is N,N-methylene bisacrylamide. The heat resistance and salt tolerance polymer filtrate reducer is good in heat stability, low in cost and high in heat resistance and salt tolerance capacity. The invention also discloses a preparation method of the heat resistance and salt tolerance polymer filtrate reducer adopting a graft copolymerization method in the aqueous solution; and the method is simple, convenient and practicable, the preparation reaction temperature does not exceed 80 DEG C, and the condition is mild and controllable.

The invention relates to the technical field of a lithium ion battery, in particular to a preparation method of a spherical hard carbon negative electrode material of a high-capacity lithium ion battery. The preparation method is characterized by comprising the following steps of (1) material mixing; (2) precrosslinked polymerization reaction; (3) crushing and grading; (4) polymer powder pelletizing treatment; (5) oxidation stability treatment; (6) pre-carbonization treatment; (7) carbonization treatment. Compared with the prior art, the preparation method has the advantages that the raw material sources are wide; the preparation process is simple; the structure and the processing performance of a precursor organic carbon source can be effectively improved through the precrosslinked polymerization reaction; the prepared spherical hard carbon has unique appearance and good pore diameter distribution, and also has the advantages of particle granularity distribution uniformity, high stacking density and the like; high capacity, high first coulombic efficiency, excellent high-rate performance and excellent circulation performance are also realized.

The invention provides a preparation method of a two-dimensional / one-dimensional heterogeneous nanochannel film. The method is characterized by comprising the following steps that step 1, graphene oxide is dissolved in an aqueous piperazine solution, and ultrasonic treatment is performed at the room temperature to obtain a uniformly dispersed first solution; step 2, the first solution is added dropwise to the upper layer of a porous aluminum oxide film, and after the solvent is evaporated at the room temperature, a first composite film with a graphene oxide film layer and a porous aluminum oxide film layer is obtained; step 3, a benzenetricarbonyl trichloride solution is added dropwise to the upper surface of the graphene oxide film layer of the first composite film, and drying is carriedout to obtain the two-dimensional / one-dimensional heterogeneous nanochannel film. The invention provides the two-dimensional / one-dimensional heterogeneous nanochannel film prepared by using the methodand application of the two-dimensional / one-dimensional heterogeneous nanochannel film in salt difference energy conversion.

The invention discloses a uric acid detection electrochemical sensor and preparation and application thereof.The electrochemical sensor comprises a glass carbon electrode and a film formed by coating the surface of the glass carbon electrode with electrically reduced graphene oxide and cuprous oxide nano particles.According to the main preparation process of the electrochemical sensor, graphite powder is used as a raw material, graphite oxide is prepared through an improved Hummers method and ultrasonically dispersed in distilled water to obtain graphene oxide sol, then the cuprous oxide nano particles are immobilized on a graphene oxide sheet by ultrasonic action, the surface of the glass carbon electrode is modified with a graphene oxide-cuprous oxide nanocomposite through a dispensing method, and finally the graphene oxide is reduced by a constant potential to obtain the electrically reduced graphene oxide and cuprous oxide nano-composite film.The uric acid detection electrochemical sensor has the advantages of being high in sensitivity, wide in linear range, low in quantity requirement, high in anti-jamming capability, short in detection time, low in cost and the like.

The invention provides a preparation method of nano hydroxyapatite. The method comprises the steps that after silk fibroin water solution is conducted to sealing incubation, silk fibroin nanosphere water solution is obtained; and the silk fibroin nanosphere water solution is mixed with a phosphate group source and a calcium source, and then nano hydroxyapatite is obtained after reaction. The invention provides another preparation method of nano hydroxyapatite. The method comprises the steps that firstly, silk fibroin water solution is treated under electrostatic field, and silk fibroin nanosphere is obtained; secondly, the silk fibroin nanosphere obtained in the first step is mixed with a phosphate group source and a calcium source, and then nano hydroxyapatite is obtained after reaction. The preparation method has the advantages that noxious solvent is not required to be used, the preparation method is simple, the condition is mild and controllable, the secondary structure of silk fibroin can not be destroyed, and silk fibroin nanosphere with controllable size and appearance can be obtained, so that nano hydroxyapatite with controllable size and appearance can be obtained.

The invention provides an aqueous graphene conductive coating material. The aqueous graphene conductive coating material comprises the raw materials in parts by weight: 1-5 parts of expanded graphite,30-70 parts of water-soluble resin emulsion, 1-5 parts of supramolecular dispersant, 10-50 parts of water and 0.2-3.5 parts of other auxiliaries. According to the aqueous graphene conductive coatingmaterial provided by the invention, the dispersity of graphene in a water-soluble resin matrix is improved greatly; and due to large-flake-diameter graphene, properties of the graphene are better exerted, the framework of a three-dimensional conductive network is facilitated, properties such as electric conductivity, impact resistance, corrosion resistance and adhesive power of products are excellent, the large-scale popularization of industrialization is facilitated, and the application prospect is broad. Stripping and dispersing of the expanded graphite and preparing of the aqueous conductive coating material are completed only through one process link, i.e., high-pressure homogenizing without a grinding medium, so that the process is simple, the cost is low, conditions are moderate andcontrollable, and the whole preparation process is safe and pollution-free.

The invention discloses a method for preparing N-(3,5-dichloropyridyl-4-yl)-3-cyclopropylmethoxy-4-difluoromethoxybenzoyl amine, which is implemented by carrying out amidation reaction on anions of 4-amino- -3,5-dichloropyridine and 3-cyclopropylmethoxy-4-difluoro-aryl-methoxybenzoate under inert solvent neutralized alkaline conditions. The preparation method disclosed by the invention has the advantages of mild reaction conditions, fewer byproducts and simple after-treatment, and obviously lowers the synthesis cost; the purity of the refined product is at least 99.8%; and the invention is more suitable for industrial large-scale production.

The invention provides a preparation method for linear nanometre hydroxylapatite. The preparation method comprises the following steps of: concentrating silk fibroin aqueous solution of a first mass concentration to a second mass concentration, and then performing sealed cultivation to acquire the silk fibroin nanofibre aqueous solution; mixing the silk fibroin nanofiber aqueous solution with a phosphate radical source and a calcium source for reaction to acquire the linear nanometre hydroxylapatite. The invention further provides a preparation method for the nanometre hydroxylapatite. The method comprises the following steps of: firstly, concentrating silk fibroin aqueous solution of a first mass concentration to a second mass concentration, and then performing a sealed cultivation to the mixture to acquire the silk fibroin aqueous solution, wherein in the process, the silk fibroin is self-organized to be silk fibroin nanofiber, so that silk fibroin nanofiber aqueous solution is acquired ; and using the silk fibroin nanofiber aqueous solution as a template to synthetize nanometre hydroxylapatite on the surface of the silk fibroin nanofiber. The silk fibroin interacts with the hydroxylapatite, so that the union of the hydroxylapatite cannot be restrained, but also, the linear nanometre hydroxylapatite can be acquired.

The invention discloses a palladium nanoparticle supported layered double hydroxide nano-composite material, a preparation method thereof, and an ammonia borane catalytic decomposition method. The preparation method comprises the following steps: 1, carrying out a coordination polymerization reaction on a cobalt source, 2-methylimidazole, a surfactant and water to prepare a coordination polymer ZIF-67; 2, carrying out a contact reaction on the coordination polymer ZIF-67 and a nickel source in an organic solvent to prepare NiCo LDH; and 3, dispersing a palladium source and the NiCo LDH in water, adjusting the pH value of the obtained system to 9.5-10.5, and carrying out a hydrothermal reaction to prepare the palladium nanoparticle supported layered double hydroxide nano-composite material.The palladium nanoparticle supported layered double hydroxide nano-composite material prepared through the method has an excellent catalysis performance, so the nano-composite material is suitable for catalytic decomposition of ammonia borane; and the preparation method has the advantages of simple steps, mild and controllable conditions, and friendliness to the environment.

The invention discloses a heat conducting nylon material based on sulfonated graphene. The heat conducting nylon material comprises the following raw materials of 95wt percent to 99.9wt percent of nylon-based material and 0.1wt percent to 5wt percent of sulfonated graphene, wherein the radial size of the sulfonated graphene is 500nm to 50mum, the thickness of the sulfonated graphene is 1 to 20nm, and the molar ratio of C (carbon) and S (sulfur) in the sulfonated graphene is (12 to 1) to (6 to 1). The invention also provides a method for preparing the heat conducting nylon material. The heat conducting nylon material has the advantages that the heat conducting coefficient of the heat conducting nylon material along the vertical direction is 0.5 to 10W per (m.k), and the self good mechanical property of the nylon material is maintained and even optimized; the preparation technology is simple, the condition is moderate and controllable, the adding amount of sulfonated graphene is less, and the cost is low; the application prospect is broad in the fields of LED (light emitting diode) lamps, switch outer casings, notebook computer outer casings, mobile phone casings and the like.

The invention discloses a graphene-loaded copper and nickel / cerium oxide nanocomposite material, a preparation method and an ammonia borane catalytic decomposition method. The preparation method comprises the steps of (1) mixing graphene oxide and water to prepare a graphene oxide water solution; (2) dispersing a nickel source, a copper source and a cerium source into the graphene oxide water solution, adding a reducing agent to a system in a nitrogen atmosphere and carrying out reducing reaction to prepare the graphene-loaded copper and nickel / cerium oxide nanocomposite material. The graphene-loaded copper and nickel / cerium oxide nanocomposite material prepared through a one-step method has an excellent catalysis effect on ammonia borane; meanwhile, the preparation method is simple in step, mild and controllable in condition and friendly to environment. In addition, decomposition of the ammonia borane can be efficiently catalyzed by using the graphene-loaded copper and nickel / cerium oxide nanocomposite material.

The invention relates to a method for preparing a carbon quantum dot by carbonizing ketone under an alkaline condition. The method comprises the following steps: uniformly mixing alkali with ketone according to a concentration proportion of 0.1mol / L to 10mol / L; reacting for 12-360 hours at the temperature of 15 to 100 DEG C; after the reaction is finished, regulating the pH of the reactants to be neutral by using concentrated hydrochloric acid; centrifugally separating, washing five times by deionized water and drying in vacuum to obtain carbon quantum dot solid powder. The method disclosed by the invention can be used for obtaining the carbon quantum dot by taking the ketone as a carbon source through a standing reaction at room temperature or through a low-temperature heating method; the method is simple, wide in raw material sources, low in cost and capable of realizing large-scale production.

The invention discloses a graphene loaded palladium-nickel / cerium oxide nano composite material, a preparation method and an amino borane catalytic decomposition method. The preparation method comprises the following steps of: 1) mixing graphene oxide, hexadecyl trimethyl ammonium bromide and water so as to obtain a graphene oxide activating system; and 2) dispersing a nickel source, a palladium source and a cerium source into the graphene oxide activating system, and adding a reducing agent into the system for a reduction reaction, thereby obtaining the graphene loaded palladium-nickel / cerium oxide nano composite material. By adopting the preparation method, the graphene loaded palladium-nickel / cerium oxide nano composite material prepared by using a one-step method has an excellent catalysis effect on amino borane, and meanwhile the preparation method is simple in step, gentle and controllable in condition and good in environment-friendliness. In addition, by adopting the graphene loaded palladium-nickel / cerium oxide nano composite material, decomposition of the amino borane can be efficiently catalyzed.

The invention discloses a method for detection of vanillin in food, and belongs to the field of analytical chemistry or the field of food safety. With a graphene-supported cuprous oxide nanoparticle composite film modified acetylene black electrode as a working electrode, the vanillin in the food is detected by an electrochemical method. The detection method has the advantages of wide linear range, high sensitivity, low detection limit, simple operation, fast detection, low detection cost and accurate results.

The invention discloses a high-strength photonic crystal hydrogel, a preparation method and an application thereof. The preparation method of the high-strength photonic crystal hydrogel comprises thefollowing steps: adopting an emulsion polymerization method for compounding a polymer colloidal crystal microsphere; swelling an oil-soluble monomer in the microsphere, thereby acquiring a colloidal crystal emulsion containing dissolved unpolymerized oil-soluble monomer; adding a water-soluble monomer acrylamide for polymerizing, thereby acquiring the high-strength photonic crystal hydrogel. According to the preparation method, the oil-soluble monomer in the microsphere participates into the polymerization of the water-soluble monomer acrylamide so as to form an oil and water bi-phase penetrated polymer netted structure in a hydrogel polymerization process, so that a higher interaction force of microsphere and bottom hydrogel can be acquired and excellent mechanical properties of high tensile and high strength can be realized. The high-strength photonic crystal hydrogel prepared according to the invention has an optical characteristic of force-induced color change, is wide in spectralresponse range, is high in sensitivity and can be applied to the fields of micro-mechanical sensors, structural color regulation, patterning and optical encrypting anti-fake.

The invention discloses a hard carbon negative electrode material for a high-performance lithium ion power battery, and a preparation method and application of the hard carbon negative electrode material, belonging to the field of electrochemistry. The hard carbon negative electrode material disclosed by the invention is doped with phosphorus, the mass ratio of a phosphorus precursor to a hard carbon precursor is (8-11):6, the hard carbon precursor is phenolic resin, the phosphorus precursor is phosphoric acid, and the particle size of the hard carbon negative electrode material ranges from 10 to 50 micrometers. The rate performance of the hard carbon negative electrode material disclosed by the invention is obviously improved, and the hard carbon negative electrode material has wide research prospect in the field of actual application of the power battery.

The invention discloses nano-hydroxyapatite and a preparation method thereof. The particular preparation method is that a regenerated silk fibroin membrane prepared by directly dissolving fibroin fibers in formic acid / calcium salt or hexafluoroisopropanol / calcium salt solutions is used as a template, and spherical nano-hydroxyapatite is prepared by aging, filtration, water washing, alcohol washing and drying at normal temperature in a phosphate solution. The preparation method and equipment of the invention is simple and low in cost, can realize continuous operation, and thus effectively shortens the preparation period; the hydroxyapatite material prepared by the method is excellent in quality, stable in performance, and uniform in particle size, has main morphology of particles, and has a particle size of 10-500 nm.

The invention discloses a phenolic resin / coal tar pitch composite-base modified hard carbon negative electrode material and a preparation method and application thereof, and belongs to the field of electrochemistry. According to the phenolic resin / coal tar pitch composite-base modified hard carbon negative electrode material, phenolic resin and coal tar pitch serve as hard carbon precursors, and the mass ratio of the phenolic resin to the coal tar pitch is 2:1-4. The phenolic resin is modified through phosphoric acid, and the mass ratio of the phosphoric acid to the phenolic resin is 1-5:10. The particle size range of the hard carbon negative electrode material is 10-50 microns. The primary coulombic efficiency of the negative electrode material under the 0.5 C multiplying power is 80.55%, under the 2 C multiplying power, the volume is kept to be about 221 mAh / g after recycling is conducted 300 times, the volume does not greatly differ from the volume under the 0.5 C multiplying power and the 1 C multiplying power, and it shows that good volume maintaining performance and coulombic efficiency are achieved.

The invention discloses a preparation method of a fluorine-doped lithium-rich manganese-based positive electrode material. The lithium-rich manganese-based positive electrode material has a chemical general formula of xLi2MnO3.(1-x) LiMO<2-y>F<2y>, wherein x is larger than or equal to 0.1 and smaller than or equal to 0.9, y is larger than 0 and smaller than or equal to 0.05, and M is one or more of Ni, Co, Mn, Cr, Fe, Ti, Mo, Ru, V, Nb, Zr and Sn. The preparation method comprises the following steps of: preparing a fluorine-doped lithium-rich manganese-based precursor through a precipitation reaction by adopting soluble metal salt, a precipitator, a soluble fluorine-containing compound and water; and uniformly mixing the fluorine-doped lithium-rich manganese-based precursor with a lithium salt, and carrying out presintering and high-temperature sintering to obtain the fluorine-doped lithium-rich manganese-based positive electrode material. According to the method, the soluble fluorine-containing compound is used as a fluorine source, fluorine doping is synchronously realized during coprecipitation of the lithium-rich manganese-based precursor, the doping uniformity is relatively good, and the cycle performance of the doped lithium-rich material is greatly improved.

The invention belongs to the technical field of catalysts, and particularly relates to an alkali metal ion modified carbon nitride catalyst, and a preparation method and application thereof. Accordingto the catalyst, carbon nitride is taken as a main body, and the alkali metal ions for modification comprise one or a combination of more selected from Na<+>, K<+> and Cs<+>, wherein the content of the alkali metal ions is 0.1-10 wt%, and the alkali metal ions in the catalyst are adsorbed on deprotonated amino nitrogen of carbon nitride through electrostatic interaction. The catalyst disclosed bythe invention can be used as a catalyst for organic sulfur hydrolysis, and shows good catalytic activity and stability.

The invention relates to the technical field of preparation of graphene, and discloses a method for preparing graphene. The method comprises the following steps of: (1) heating a substrate to growth temperature of the graphene and carrying out annealing processing; (2) filling an organic carbon source and hydrogen into a reaction system, and carrying out growth of the graphene on the surface of the substrate obtained in the step (1); (3) cooling the substrate obtained in the step (2), wherein in the step (1), a temperature rising rate of the heating is 10 to 100 DEG C per minute and time of the annealing is 1 to 60 minutes, in the step (2), a filling flow rate of the organic carbon source to the hydrogen is 1: (1 to 10), and in the step (3), a cooling rate of the cooling is 10 to 100 DEG C per minute. When the method provided by the invention is adopted to prepare the graphene, in the whole preparing process, carrier gas does not need to be used, gas consumption is low and conditions are mild and controllable. A single-layer graphene thin film can be prepared by the method provided by the invention, the surface of the obtained graphene is flat and has no obvious wrinkles, and the obtained graphene has an excellent electrical conductivity and optical property.

The invention discloses a polymeric micelle freeze-dried preparation of taxane anti-tumor drugs as well as a preparation method and an application of the polymeric micelle freeze-dried preparation. The polymeric micelle freeze-dried preparation consists of a polyether / polyester segmented copolymer and taxane drugs, wherein the weight ratio of the polyether / polyester segmented copolymer to the taxane drugs is at (1-99) to 1; and in the polyether / polyester segmented copolymer, the molecular weight ratio of polyether to polyester is at 1 to (0.5-2). According to the taxane anti-tumor drug polymeric micelle freeze-dried preparation prepared by the invention, the physical stability of a redissolved solution is significantly increased; and meanwhile, the occurrence rate of a guinea pig allergic reaction in the taxane anti-tumor drug polymeric micelle freeze-dried preparation prepared from the polyether / polyester segmented copolymer which is subjected to ultrafiltration and freeze-drying treatment is obviously reduced, so that the safety of the taxane anti-tumor drug polymeric micelle freeze-dried preparation is further enhanced.

The invention discloses a preparation method of spherical nano hydroxyapatite particles. The preparation method comprises the following steps: (1) measuring a CQDs (carbon quantum dots) solution in a conical flask, regulating the pH value of the solution up to 10, and uniformly stirring at room temperature; (2) dropwisely adding a CaCl2 solution, and uniformly stirring; (3) dropwisely adding a Na2HPO4.12H2O solution, and standing at room temperature; (4) performing centrifugal separation on the prepared product, discarding the supernate, washing the underlayer product with distilled water and anhydrous ethanol respectively, then taking out the product, and drying in a drying oven to obtain khaki powder; and (5) calcining the powder in a muffle furnace, thereby removing carbon quantum dots to obtain white powder, namely HAP (hydroxyapatite) nanoparticles. According to the invention, the spherical hydroxyapatite nanoparticles are prepared at room temperature by using the carbon quantum dots as effective nucleation inducer through a chemical precipitation method. The hydroxyapatite prepared by the invention is quasi-spherical, and has the advantages of favorable dispersity, particle uniformity and high crystallinity. Besides, the preparation method has the advantages of simplicity, mild and controllable conditions and low cost.

The invention discloses a preparation method of a mixed organic acid and salts thereof. The preparation method of the mixed organic acid and the salts thereof comprises the following steps: taking a biomass, pretreating the biomass, reacting with oxidants and catalysts to obtain the mixed organic acid and the salts thereof, wherein the biomass is selected from at least one of cellulose, hemicelluloses, lignin, crop straw, corncob, Chinese silvergrass, pine, white birch and poplar. The preparation method of the mixed organic acid and the salts thereof is low in production cost, free of pollution to environment, simple in process, short in production cycle and high in yield, and is suitable for mass production.

The invention discloses a spinel phase coated lithium-rich material Li1.87Mn0.94Ni0.19O3, a preparation method and an application therefor, and belongs to the electrochemical technical field. The invention discloses a new material used as a lithium ion battery positive electrode, namely the spinel phase coated lithium-rich material Li1.87Mn0.94Ni0.19O3, and the preparation method is simple. When the material is used as the positive electrode material of a button lithium battery, the cycling stability of the button lithium battery under a high rate of 1C (250 mA / g) can be improved, and a relatively high specific capacity can be ensured as well; at present, the stable cycling performance of the button lithium battery under the rate of 1C is improved to be more than 200 circles; and meanwhile, the capacity is kept at about 180mA / g.

The invention provides a preparation method of nano-composite hydrogel and application of the nano-composite hydrogel in promoting healing of diabetic wounds. The method comprises the following steps: preparing a functionally modified natural high-molecular polymer and functional metal oxide nanoparticles, mixing the functionally modified natural high-molecular polymer solution with the functional metal oxide nanoparticles, and finally preparing the nano composite hydrogel by means of enzymatic crosslinking and photo-crosslinking. The hydrogel prepared by the method has multiple functions, and can be used for adjusting the pathological microenvironment of the diabetic wound to promote the healing of the diabetic wound.

The invention discloses a sugarcoated-haws-on-stick shaped one-dimensional gold nano-particle preparation method. The preparation method comprises the steps of using an anionic surfactant-biomolecule A-HAuC14 mixed system as a reaction system, performing reaction at room temperature to produce one-dimensional sugarcoated-haws-on-stick shaped gold nano-particles. The sugarcoated-haws-on-stick shaped one-dimensional gold nano-particle preparation method has the advantages that the reaction system is simple and easy to operate and moderate in condition; a reducing agent is bio-molecules and has the environment-friendly characteristic; a product is controllable in shape and particle size, large in yield and clear in structure and the like.

The invention discloses a preparation process of a phosphorus-doped biomass three-dimensional porous carbon nano electrode material for a long-service-life sodium ion battery; the preparation processcomprises the steps of sequentially carrying out ultrasonic cleaning on a biomass waste by using deionized water and ethanol, and then performing drying, and crushing into powder, and sieving to obtain a powdery A; adding a phosphoric acid solution into the powdery A, and carrying out ultrasonic-assisted mixing to obtain a mixture B; transferring the mixture B into a hydrothermal induction kettle,and adding carbon cloth as a sensing source, transferring the hydrothermal induction kettle into hydrothermal induction heating equipment for reaction, and then cooling to room temperature, taking out the carbon cloth, scraping the obtained product and carrying out cleaning and suction filtration by deionized water and ethyl alcohol, and drying to obtain C; mixing the C and the phosphorus source,calcining, cooling to room temperature, washing the obtained product with deionized water and ethyl alcohol, and centrifuging to obtain D; and activating the D to obtain the phosphorus-doped biomassthree-dimensional porous carbon nano electrode material

The invention relates to the technical field of batteries, in particular to a hard carbon composite material and a preparation method and application thereof. The preparation method of the hard carbon composite material comprises the following steps: carrying out heat treatment on a mixture of a hard carbon material and asphalt under an inert gas condition; the preparation method of the hard carbon material comprises the following steps: sequentially carrying out phosphoric acid treatment, curing treatment, carbonization treatment and crushing treatment on phenolic resin. Phenolic resin is used as a precursor, phosphoric acid is used for carrying out modification treatment, then curing, carbonization and smashing treatment are carried out, a hard carbon material is obtained, asphalt is used as a precursor for carrying out surface coating treatment on the hard carbon material, and the hard carbon composite material is obtained. The method is simple, conditions are mild and controllable, and the obtained hard carbon composite material can endow the battery with excellent cycle performance and rate capability.