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Nano-hydroxyapatite and preparation method thereof

A technology of nano-hydroxyapatite and hydroxyapatite, which is applied in the direction of nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of expensive raw materials, unsuitable for large-scale production, cumbersome preparation process, etc. Controllable, mild and controllable conditions, simple preparation method

Active Publication Date: 2014-04-23
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods can obtain hydroxyapatite nanomaterials, but the preparation process is cumbersome and the required raw materials are expensive, which is not suitable for large-scale production

Method used

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  • Nano-hydroxyapatite and preparation method thereof

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Effect test

Embodiment 1

[0020] A preparation method of nano-hydroxyapatite, comprising the steps of:

[0021] (1) Natural mulberry silk was degummed by boiling 0.05% sodium carbonate solution for 30 min, and the pure silk fibroin fiber was obtained after repeated 3 times; the silk fibroin fiber was dissolved in the mixed solution of formic acid / calcium chloride, Wherein the mass ratio of silk fibroin fiber and calcium chloride is 1:0.5, magnetically stirred at room temperature for 3 hours to obtain a regenerated silk fibroin solution with a mass fraction of 5%, the regenerated silk fibroin solution is formed into a film, dried, washed with water, and then dried , to obtain a regenerated silk fibroin film;

[0022] (2) will (NH 4 ) 2 HPO 4 Prepared into 0.5mol / L (NH 4 ) 2 HPO 4 aqueous solution, and adjust the pH value of the solution to 11 with ammonia water; put the regenerated silk fibroin film into 0.5mol / L (NH 4 ) 2 HPO 4 In an aqueous solution, aging at room temperature for 3 hours, fil...

Embodiment 2

[0025] (1) Natural mulberry silk was degummed by boiling with 0.05% sodium carbonate solution for 30 min, and the pure silk fibroin fiber was obtained after repeated 3 times; the silk fibroin fiber was dissolved in the mixed solution of formic acid / calcium nitrate, wherein The mass ratio of silk fibroin fiber and calcium nitrate is 1:1, and magnetically stirred at room temperature for 3 hours to obtain a regenerated silk fibroin solution with a mass fraction of 20%. The regenerated silk fibroin solution is formed into a film, dried, washed with water, and then dried to obtain regenerated silk fibroin film;

[0026] (2) put H 3 PO 4 Prepared into 0.1mol / L H 3 PO 4 aqueous solution, and adjust the pH value of the solution to 7 with ammonia water; put the regenerated silk fibroin film into 0.1mol / L H 3 PO 4 In the aqueous solution, stand at room temperature for aging reaction for 120 hours, filter, wash with deionized water and absolute ethanol for 10 minutes, and then dry a...

Embodiment 3

[0028] (1) Natural tussah silk was degummed by boiling with 0.5% sodium carbonate solution for 30 minutes, and the pure silk fibroin fiber was obtained after repeated 3 times; the silk fibroin fiber solution was dissolved in hexafluoroisopropanol / calcium chloride In the mixed solution, wherein the mass ratio of silk fibroin fiber and calcium chloride is 20:1, magnetically stirred at room temperature for 6h to obtain a regenerated silk fibroin solution with a mass fraction of 0.2%, the regenerated silk fibroin solution is formed into a film, and dried , washed with water, and then dried to obtain a regenerated silk fibroin film;

[0029] (2) will (NH 4 ) 2 HPO 4 Prepared into 0.2mol / L (NH 4 ) 2 HPO 4 aqueous solution, and the pH value of the solution was adjusted to 6 with hydrochloric acid; the regenerated silk fibroin film was placed in 0.2mol / L (NH 4 ) 2 HPO 4 In the aqueous solution, stand at room temperature for aging reaction for 24 hours, filter, wash with deioni...

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Abstract

The invention discloses nano-hydroxyapatite and a preparation method thereof. The particular preparation method is that a regenerated silk fibroin membrane prepared by directly dissolving fibroin fibers in formic acid / calcium salt or hexafluoroisopropanol / calcium salt solutions is used as a template, and spherical nano-hydroxyapatite is prepared by aging, filtration, water washing, alcohol washing and drying at normal temperature in a phosphate solution. The preparation method and equipment of the invention is simple and low in cost, can realize continuous operation, and thus effectively shortens the preparation period; the hydroxyapatite material prepared by the method is excellent in quality, stable in performance, and uniform in particle size, has main morphology of particles, and has a particle size of 10-500 nm.

Description

technical field [0001] The invention relates to an inorganic nano material and a preparation method thereof, in particular to a nano-hydroxyapatite and a preparation method thereof. Background technique [0002] Hydroxyapatite is an important inorganic component that constitutes the hard tissue of the human body. It has good biocompatibility, bone conduction performance, high chemical stability, and does not produce harmful substances after degradation. It can promote the growth of new bone when implanted in the body. An ideal implant carrier material. The preparation methods of hydroxyapatite can be divided into dry preparation and wet preparation. Wet preparation mainly adopts chemical precipitation method, hydrothermal synthesis method and sol-gel method, etc. [0003] With the development of nanomaterial preparation technology, the preparation of nano-hydroxyapatite has ushered in new opportunities for development. Using technologies such as biomimetic mineralization a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00
Inventor 明津法张锋左保齐
Owner SUZHOU UNIV
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