Method for preparing hollow mesoporous silica nanosphere loaded propranolol hydrochloride composite system

A technology of propranolol hydrochloride and mesoporous silica is applied in the field of preparing hollow mesoporous silica nanospheres supporting propranolol hydrochloride composite system, and can solve the problems of difficult control, long preparation time, complicated operation and the like

Active Publication Date: 2021-04-20
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]However, most of the drug loading methods reported in the literature at this stage have problems such as complicated operation, long preparation time, low drug loading and difficult to control

Method used

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  • Method for preparing hollow mesoporous silica nanosphere loaded propranolol hydrochloride composite system
  • Method for preparing hollow mesoporous silica nanosphere loaded propranolol hydrochloride composite system
  • Method for preparing hollow mesoporous silica nanosphere loaded propranolol hydrochloride composite system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Solid silica spheres (sSiO 2 ) preparation

[0042] Prepare solution A: Put 2mL of 28% concentrated ammonia water, 16.25mL of absolute ethanol and 24.75mL of deionized water into a 250mL three-neck flask, and place it in a constant temperature water bath at 24°C and 1100rpm magnetic stirring for 30min.

[0043] Prepare solution B: put 4.5mL tetraethyl orthosilicate and 45.5mL absolute ethanol into a 100mL beaker, seal it with plastic wrap, and ultrasonically dissolve it for 45min.

[0044] Quickly add B to A, reduce the stirring speed to 360-400rpm after 1min, and react in a constant temperature water bath at 24°C for 2h, then centrifuge the product and wash it with ethanol (three times, centrifuge speed 8000rpm, time 5min), and then put it in a vacuum dryer Store in airtight after drying.

[0045] (2) Preparation of hollow mesoporous silica nanospheres (HMSS)

[0046] 50 mg of prepared sSiO 2 After ultrasonic treatment for 15 min, it was uniformly dispersed in ...

Embodiment 2

[0055] (1) Solid silica spheres (sSiO 2 ) preparation

[0056] With embodiment 1.

[0057] (2) Preparation of hollow mesoporous silica nanospheres (HMSS)

[0058] 50 mg of prepared sSiO 2 After ultrasonic treatment for 15 min, it was uniformly dispersed in 9 mL of deionized water, and then 1 mL of cetyltrimethylammonium bromide aqueous solution (12.5 mg / mL) was added and stirred at room temperature for 30 min. Anhydrous sodium carbonate (212 mg) was added to the mixture, and after stirring at 35 °C, 1500 rpm for 24 h, the product was collected by centrifugation and washed with deionized water and ethanol and dried. The dried solid was heated to 550 °C in air at a rate of 1.5 °C / min and kept for 6 h to obtain hollow mesoporous silica nanospheres (HMSS).

[0059] (3) Preparation of propranolol hydrochloride solution

[0060] Weigh 161 mg of propranolol hydrochloride and dissolve it in 7 mL of methanol to obtain a solution with a concentration of 23 mg / mL, and weigh 500 mg o...

Embodiment 3

[0067] (1) Solid silica spheres (sSiO 2 ) preparation

[0068] With embodiment 1.

[0069] (2) Preparation of hollow mesoporous silica nanospheres (HMSS)

[0070] With embodiment 1.

[0071] (3) Preparation of propranolol hydrochloride solution

[0072] Weigh 231 mg of propranolol hydrochloride and dissolve it in 7 mL of methanol to obtain a solution with a concentration of 33 mg / mL, and weigh 500 mg of hollow mesoporous silica nanospheres.

[0073] (4) drug load

[0074] Slowly add the propranolol hydrochloride solution to the hollow mesoporous silica nanospheres, drop 0.6mL each time to form a viscous paste and there is no clear liquid in the upper layer, put the paste in a constant temperature blast drying oven Dry at 50°C, then continue to add 0.6mL propranolol hydrochloride solution dropwise until a paste is formed, dry, and repeat the operation until all the propranolol hydrochloride solution is added dropwise.

[0075] (5) washing

[0076] The composite system ob...

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Abstract

The invention relates to a method for preparing a hollow mesoporous silica nanosphere loaded propranolol hydrochloride composite system. The method comprises the following steps of: (1) preparing solid silica spheres; (2) preparing hollow mesoporous silica nanospheres; (3) preparing a propranolol hydrochloride solution; (4) loading propranolol hydrochloride onto the hollow mesoporous silica nanospheres; and (5) performing washing. The hollow mesoporous silica nanospheres prepared by the method disclosed by the invention are adjustable in particle size, good in monodispersity, uniform in particle size and high in propranolol hydrochloride drug loading capacity, and have a slow-release structure.

Description

technical field [0001] The invention relates to a method for preparing a composite system of propranolol hydrochloride supported by hollow mesoporous silicon dioxide nanospheres. Background technique [0002] With the development of nanotechnology, a variety of nano drug delivery systems based on organic and inorganic materials have been developed, and hollow mesoporous silica nanospheres (HMSS) due to their unique characteristics, such as internal hollow structure, high pore volume, Ordered channels, large surface area, etc. are used as carriers for traditional drugs such as propranolol hydrochloride, thereby improving their pharmacokinetic and pharmacodynamic properties. [0003] At present, the most commonly used method for preparing hollow mesoporous silica nanoparticles is the template method, which can be divided into soft template method, hard template method and self-template method. The templating agent of the soft template has strict requirements on the reaction c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18A61K31/138A61K47/69
Inventor 许永权李凯赵瑞红张向京李昆杰解楠宋可欣
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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