Preparation method of cefuroxime acid

A technology of cefuroxime acid and methoxyiminofuran acetyl chloride dichloromethane, applied in the field of preparation of cefuroxime acid, can solve problems such as poor stability, and achieve the effects of good stability, improved stability and high yield
CN112679525AActive Publication Date: 2021-04-20QILU ANTIBIOTICS PHARMA
7 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
QILU ANTIBIOTICS PHARMA
Publication Date
2021-04-20

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a preparation method of cefuroxime acid, wherein the preparation method comprises the following steps: (1) adding D-7ACA into water, and dropwisely adding an alkali solution to dissolve; adding a methoxyimino furan acetyl chloride dichloromethane solution to carry out acylation reaction, layering to obtain a water phase after the reaction is finished, adding activated carbon to decolorize, filtering, then adding dichloromethane, dropwise adding hydrochloric acid to crystallize, filtering and drying to obtain MDCC; and (2) adding MDCC into an organic solvent, adding chlorosulfonyl isocyanate to carry out aminomethyl acylation reaction, and after the reaction is finished, adding pre-cooling water to hydrolyze to obtain a cefuroxime acid suspension; and dropwise adding an alkaline solution for multiple times, growing crystals after dropwise adding is completed each time, finally adjusting the pH value of the system to 1.0-2.0, filtering, and washing to obtain the cefuroxime acid product. The obtained product is good in stability, good in product flowability and easy to subpackage; the crystallization size phase of the product is greatly improved, and the stability is obviously improved.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a preparation method of cefuroxime acid, belonging to the technical field of medicine synthesis. Background technique

[0002] Cefuroxime acid (see formula I) is the intermediate of cefuroxime sodium, and cefuroxime sodium belongs to second-generation cephalosporins. It inhibits cell division and growth by binding to penicillin-binding proteins (PBPs) on the bacterial cell membrane, and finally lyses and kills the bacteria. Cefuroxime has a broad-spectrum antibacterial effect and a wide range of applications. It can be used for respiratory infections caused by sensitive bacteria, ear, nose, throat infections, urinary tract infections, skin and soft tissue infections, bone and joint infections, gonorrhea, including sepsis and Meningeal and other infections.

[0003] At present, the processing route of producing cefuroxime acid (see formula I) at home and abroad takes 7-aminocephalosporanic acid (7-ACA) or deacetyl 7-aminocepha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More