Solid preparation containing composite-form telmisartan and preparation method of solid preparation

A technology for telmisartan and solid preparation, which is applied to the composite form of telmisartan solid preparation with low content of alkaline substances and the field of preparation thereof, and can solve the problems of poor dissolution rate, high content of alkaline substances, slow dissolution rate, etc. question

Inactive Publication Date: 2021-04-23
海南涛生医药科技研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0019] Specifically, the primary purpose of the present invention is to provide a telmisartan solid preparation containing low content of alkaline substances and improving dissolution rate, ...

Method used

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  • Solid preparation containing composite-form telmisartan and preparation method of solid preparation
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  • Solid preparation containing composite-form telmisartan and preparation method of solid preparation

Examples

Experimental program
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preparation example 1

[0096]Preparation 1: Preparation of high-uniform small particulate Misassartan crystals

[0097]S1: Preparation of high-uniform small particulate Misassartan crystals

[0098]1) In the reaction vessel with reflux condensation, the metamin (purity greater than 99%) is dissolved in formic acid-isopropanol (volume ratio 1: 5), formulated into a concentration of 8 g / 100 ml For Misassarta solution A, heated and refluxed to completely dissolved, cooling to about 75 ° C, spare; simultaneously, the deionized water is cooled to 1-2 ° C, as solvent B;

[0099]2) In the tubular reactor connected to a crystal growth, the above-described Timartan solution A and the solvent B are pumped into the reactor in the reactor via the top and side of the two different inlets, and generate crystals. Nucleic; wherein the solution A flow rate is 10 ml / sec, the solvent B flow is 60 ml / sec; the formed mixture of crystal microparticles is incorporated into the crystal kettle;

[0100]3) In a crystal tank having a tem...

preparation example 2

[0101]Preparation 2: Making replacement Misassarta micronized solid dispersion

[0102]S1: Making replacement Misassartan - cycloderathry premix

[0103]1) We will weigh the above-mentioned small particles Timartan 0.1 kg and 0.5 kg of composite cycloderathry (from 80% by weight of sulfury ether-β-cyclodextrin and 20% by weight of sulfury ether-γ). Cyclodextrin composition), a total of about 0.6 kg; a mixed solvent (ethanol volume ratio of ethanol) 4.5 L is pre-added in the water bath reaction kettle, and the proposed composite cyclodextrial derivative is added to the reactor, Heat until 70 ~ 72 ° C, stirred to dissolution, and then added to the Misassartan continued to stir for 15 min for sufficient mixing; stop heating and stirring, cooled to room temperature;

[0104]2) The above-mentioned solution is sprayed and dried to obtain gray-white fine particles; the spray pressure is about 3 bar, and the outlet air temperature is about 80 ° C. The resulting dry particle powder was over 140 mesh ...

preparation example 3A

[0107]Preparation Example 3A: Making replacement Misaartan Compound Particles 1

[0108]1) Make a crude rice salt

[0109]At room temperature, 86 g of sodium hydroxide was dissolved in 1.2 kg of deionized water to obtain an alkaline solution, stirred sufficiently to dissolve it; add 1 kg of Misassartan, heating to 35 ° C for 20 min; then cooled to room temperature; stirring The product mixture was slowly added to about 10 l ethanol, stirred slowly at 4 ° C for 1 h, and then filtered after 30 min, and the resulting filter cake was dried to give a crude material.

[0110]S2: Making replacement Misassart Sodium composite particles

[0111]1) Under room temperature and rapid stirring conditions, 1 kg of misa sodium and 10.5 g of sodium carbonate, 40 g of gluchanamine, 320 g Piwifen is added to 5L deionized water, and the material is stirred until it is completely clarified to obtain it. Mishaan sodium premix solution;

[0112]2) The sorbitol will be proud of the sorbitol, first adding the half amount ...

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Abstract

The invention provides a telmisartan solid preparation containing low-content alkaline substances and capable of improving the dissolution rate and a preparation method of the telmisartan solid preparation. The telmisartan solid preparation comprises telmisartan sodium composite particles, a micronized solid dispersion prepared from high-uniformity small-particle telmisartan and proper auxiliaries; the solid preparation is a tablet or a coated tablet; and the mass dosage of the telmisartan micronized solid dispersion in the telmisartan solid preparation is not more than 40wt% of the telmisartan sodium composite particles. The telmisartan solid preparation has lower alkaline substance content, and has the characteristics that the active components can be rapidly dissolved and rapidly release medicines and good stability.

Description

Technical field[0001]The present invention belongs to the field of pharmaceutical preparations, and more particularly to a composite form of a low content alkaline substance and a preparation method thereof.Background technique[0002]Temisham is an oral non-peptide vascular tension tensioner antagonist, which can effectively control blood pressure, which is strong, and it is difficult to dissolve in water. Temisham is usually prepared in acid form, and crystallization is present in polycrystalline form. Currently, most parts of Mishatan are solid tablets and capsules. However, since the mesham is difficult to dissolve in water, the form of tablets is usually less dissolved, and the solubility of the aqueous solution is poor.[0003]In order to improve the solubility problem in the gastrointestinal tract, overcome the defects of the meshamin in water. When producing, the addition of a certain amount of sodium hydroxide and / or glucomethyme is used to make it Salt thus increased solubil...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/4184A61K47/69A61K47/32A61K47/18A61K47/02A61K47/26A61P9/12A61K9/20A61J3/00
CPCA61J3/00A61K9/1611A61K9/1617A61K9/1635A61K9/1682A61K9/2095A61K31/4184A61K47/6951A61P9/12C07D235/18
Inventor 汪淮胜陈太博王辉
Owner 海南涛生医药科技研究院有限公司
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