Solid preparation containing composite-form telmisartan and preparation method of solid preparation

A technology for telmisartan and solid preparation, which is applied to the composite form of telmisartan solid preparation with low content of alkaline substances and the field of preparation thereof, and can solve the problems of poor dissolution rate, high content of alkaline substances, slow dissolution rate, etc. question
CN112691082AInactive Publication Date: 2021-04-23海南涛生医药科技研究院有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
海南涛生医药科技研究院有限公司
Publication Date
2021-04-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a telmisartan solid preparation containing low-content alkaline substances and capable of improving the dissolution rate and a preparation method of the telmisartan solid preparation. The telmisartan solid preparation comprises telmisartan sodium composite particles, a micronized solid dispersion prepared from high-uniformity small-particle telmisartan and proper auxiliaries; the solid preparation is a tablet or a coated tablet; and the mass dosage of the telmisartan micronized solid dispersion in the telmisartan solid preparation is not more than 40wt% of the telmisartan sodium composite particles. The telmisartan solid preparation has lower alkaline substance content, and has the characteristics that the active components can be rapidly dissolved and rapidly release medicines and good stability.
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Description

Technical field

[0001] The present invention belongs to the field of pharmaceutical preparations, and more particularly to a composite form of a low content alkaline substance and a preparation method thereof.Background technique

[0002] Temisham is an oral non-peptide vascular tension tensioner antagonist, which can effectively control blood pressure, which is strong, and it is difficult to dissolve in water. Temisham is usually prepared in acid form, and crystallization is present in polycrystalline form. Currently, most parts of Mishatan are solid tablets and capsules. However, since the mesham is difficult to dissolve in water, the form of tablets is usually less dissolved, and the solubility of the aqueous solution is poor.

[0003] In order to improve the solubility problem in the gastrointestinal tract, overcome the defects of the meshamin in water. When producing, the addition of a certain amount of sodium hydroxide and / or glucomethyme is used to make it Salt thus increased solubil...

Claims

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