Application of momordica polysaccharide in preparation of medicine for treating ulcerative colitis and medicinal preparation thereof

A technology for ulcerative colitis and bitter gourd polysaccharide, which is applied in the field of biomedicine and can solve problems such as no literature report on application.

Active Publication Date: 2021-04-23
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The polysaccharide extract of bitter melon - Momordica Charantia Polysaccharide (MCP) has antibacterial, anti-oxidant, regulates and improves the body's immunity, activates or promotes the generation of antibody complement, induces interferon, promotes gastric ulcer healing and repair, etc. As a bioactive component, it has become one of the research hotspots of natural medicine in recent years, but there is no literature report on the application of Momordica charantia polysaccharide in improving ulcerative colitis

Method used

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  • Application of momordica polysaccharide in preparation of medicine for treating ulcerative colitis and medicinal preparation thereof
  • Application of momordica polysaccharide in preparation of medicine for treating ulcerative colitis and medicinal preparation thereof
  • Application of momordica polysaccharide in preparation of medicine for treating ulcerative colitis and medicinal preparation thereof

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Embodiment Construction

[0026] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0027] Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the technical field, and the kit materials used in the following examples are all commercially available.

[0028] The bitter gourd polysaccharides involved in the following examples are extracted by the following methods:

[0029] Put the fresh bitter gourd slices into a drying oven with a temperature controlled at 50°C for drying and dehydration treatment, then grind the dried bitter gourd slices with a grinder, and pass through a 0.38 mm sieve to obtain bitter gourd powder. Bitter melon powder was reflux extracted with 80% ethanol hot water bath, the solid-liquid ratio (g / ml) was 1:3, the reaction temperature was 80°C, and the reaction time was 2h. The leached bitter gourd powder ...

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Abstract

The invention discloses application of momordica polysaccharide in preparation of a medicine for treating ulcerative colitis and a medicinal preparation thereof, and belongs to the field of biological medicine. The ulcerative colitis is induced by dextran sodium sulfate. Experiments show that the momordica polysaccharide reduces disease activity indexes and improves clinical symptoms by restoring body weight and excrement viscosity and reducing bleeding; an intestinal tract damaged by inflammation is protected by repairing the mucosal barrier function of a colon tissue; and immune system disorders of the ulcerative colitis are ameliorated by attenuating expression of inflammatory cytokines in the colon and reducing recruitment of CD4+T cells. The application field of the momordica polysaccharide is widened, an experimental basis is provided for clinical application of the momordica polysaccharide in preparation of the medicine for treating the ulcerative colitis, and the momordica polysaccharide has a good application prospect and huge potential value and social significance.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of bitter gourd polysaccharide in the preparation of medicines for treating ulcerative colitis and its pharmaceutical preparations. Background technique [0002] Ulcerative colitis is a continuous inflammation of the colonic mucosa and submucosa, which can be produced by changing the composition of the intestinal flora, weakening the barrier function of the intestinal mucosa, and proliferating virulent bacteria, which can even lead to colon cancer. The pathogenesis of ulcerative colitis is related to environmental, genetic and immune factors, and its incidence and prevalence are increasing year by year worldwide. Although the fatality rate is not high, millions of patients suffer from recurrent episodes of ulcerative colitis, which places an enormous burden on the healthcare system. [0003] The dextran sulfate sodium (DSS)-induced ulcerative colitis model is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P1/00A61P1/04A61P29/00A61K36/42
CPCA61K31/715A61P1/00A61P1/04A61P29/00A61K36/42
Inventor 杨欢胡君怡吴小小齐素华单云洁
Owner XUZHOU MEDICAL UNIV
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