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Temperature photoacoustic imaging and precise control method and system based on nano photothermal preparation

A nano-light and preparation technology, applied in the field of biomedical engineering, to achieve the effect of high-efficiency deep tissue temperature imaging and precise control, good biocompatibility, and increased photostability

Pending Publication Date: 2021-04-23
HARBIN INST OF TECH AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Infrared imaging non-contact temperature measurement technology can only measure the temperature of the tissue surface

Method used

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  • Temperature photoacoustic imaging and precise control method and system based on nano photothermal preparation
  • Temperature photoacoustic imaging and precise control method and system based on nano photothermal preparation
  • Temperature photoacoustic imaging and precise control method and system based on nano photothermal preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0061] The preparation of embodiment 1 nano photothermal preparation

[0062] Weigh 1.25 mg of indocyanine green and dissolve in a mixed solvent of chloroform and ethanol (the volume ratio of chloroform and ethanol is 20:1) to form a solution containing indocyanine green with a concentration of 0.1 mg / mL. Dilute 200mg of human serum albumin with water for injection into a 5% (w / w) albumin aqueous solution. Under the action of a high-pressure homogenizer, the pressure was adjusted to 500 bar, the indocyanine green solution was injected into the albumin aqueous solution, emulsified for 4 minutes, washed with centrifugal ultrafiltration water three times, and the indocyanine green nano-photothermal preparation wrapped with albumin was prepared . Detected with a DelsaTM Nano C particle size distribution analyzer, the particle size range is 20-400nm.

Embodiment 2

[0063] Example 2 temperature photoacoustic imaging

[0064] The albumin-coated indocyanine green nanophotothermal preparation prepared in Example 1 was configured as a 540 μg / ml aqueous solution, and 0.5ml of the photothermal preparation solution was added to 1mg agar and 0.5mg carbon powder to make a height of 10mm. A human tumor mimic with a diameter of 8mm. Then make a pure agar analog with a mass fraction of 2%. The human tumor phantom was placed 18 mm below the surface of the pure agar phantom.

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Abstract

The invention relates to a temperature photoacoustic imaging and precise control method and a system based on a nano photothermal preparation. The photoacoustic ultrasonic temperature multi-mode imaging system comprises a laser, a coupling light path, an annular light emitting optical fiber, an ultrasonic transducer, an image acquisition and processing equipment, an upper computer and a lower computer; the laser emits pulse laser, the pulse laser enters the annular light emitting optical fiber through a coupling light path to excite human tissue to generate ultrasonic signals, and meanwhile laser energy changes the temperature of the human tissue; wherein the change of the temperature causes the change of the ultrasonic signals, and the ultrasonic transducer captures the ultrasonic signals; the ultrasonic signals are transmitted to the image acquisition and processing equipment, and carrying out temperature pseudo-color image reconstruction work through a photoacoustic temperature image sensitive factor extraction algorithm; and the upper computer extracts temperature information in the ultrasonic signals and continuously regulates and controls the power of the laser through a control algorithm. The invention is based on nano photothermal preparation, the temperature imaging and accurate control of deep tissue can be achieved accurately, efficiently and in real-time by adopting a photoacoustic imaging technology.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a temperature photoacoustic imaging and precise control method and system based on nano-photothermal preparations. Background technique [0002] Tumor photothermal therapy uses targeted photothermal preparations to convert the absorbed near-infrared light energy into thermal energy under the irradiation of a light source of a specific wavelength, so that the temperature of the tumor site rises rapidly above 42°C to generate local high temperature and kill tumor cells to achieve therapeutic effect. tumor purpose. Due to the advantages of non-invasiveness, no ionizing radiation, high detection sensitivity and good treatment selectivity, photothermal therapy of tumors is rapidly developing and has become a new field of cancer treatment. [0003] At present, clinical temperature measurement technology is mainly divided into two types: contact and non-contact measure...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/42A61K49/00A61K49/22A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00A61B5/00A61B5/01
CPCA61K41/0052A61K9/5169A61P35/00A61K49/225A61K49/0002B82Y5/00B82Y30/00B82Y40/00B82Y20/00A61B5/0095A61B5/01
Inventor 孙明健马一鸣秦泽政高源远
Owner HARBIN INST OF TECH AT WEIHAI
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