Method for preparing preparation for treating habitual diarrhea from traditional Chinese medicinal material pomelo fruit and application
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A habitual, traditional Chinese medicinal material technology is applied in the field of medicinal material pomelo fruit to prepare preparations for treating habitual diarrhea, and can solve the problems of decreased efficacy, unstable properties, complex components and the like
Inactive Publication Date: 2021-05-07
古练权
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[0008] Naringin belongs to the dihydroflavonoid compound, and its properties are very unstable; under the condition of aqueous solution, it is easily oxidized into complex oxidation products
In addition, naringin is easily soluble in water, and the pomelo fruit extract obtained by water extraction not only loses a lot of its active ingredients naringin and other flavonoids, but also becomes very complex, which directly leads to a decrease in the efficacy of the medicine and cannot be obtained. Increased known side effects
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Embodiment 1
[0026] The preparation of embodiment 1 pomelo fruit powder
[0027] Select well-preserved and dried Meizhou pomelo fruit, slice, crush and pass through 80 meshes; after removing impurities, the off-white powder is obtained, which is the pomelo fruit powder.
[0028] Detected by liquid chromatography, the content of naringin in pomelo fruit powder is 22.83%, such as figure 1 as shown, figure 1 Among them, A is the reference substance of naringin, B is the whole pomelo fruit powder, and C is the blank solvent.
[0029] Instrument: Shimadzu LC20AB high performance liquid chromatography.
[0030] Chromatographic column: Agilent Eclipse XDB-C18, 4.6×250 mm, 5 μm.
[0031] Chromatographic conditions: the mobile phase is methanol-acetic acid-water (35:4:61, volume ratio), the flow rate is 0.8mL / min, and the detection wavelength is 283nm.
Embodiment 2
[0032] The preparation of embodiment 2 grapefruit tablet
[0033] Get 80 parts of pomelo fruit powders prepared in Example 1, 10 parts of crospovidone (PVPP), 4 parts of microcrystalline cellulose (MCC), 4 parts of carboxymethylcellulose sodium (CMC-Na), 2 parts of vitamin C parts), after mixing evenly, spray and moisten with 95% ethanol by volume fraction, and press into tablets. The specification is 0.3 g / tablet, and each tablet contains 50 mg or more of the active ingredient naringin.
Embodiment 3
[0034] The preparation of embodiment 3 grapefruit capsules
[0035] Get 80 parts of pomelo fruit powders prepared in Example 1, 10 parts of crospovidone (PVPP), 4 parts of microcrystalline cellulose (MCC), 4 parts of carboxymethylcellulose sodium (CMC-Na), 2 parts of vitamin C , mix well and put into capsules. The specification is 0.3 g / capsule, and each capsule contains 50 mg or more of the active ingredient naringin.
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Abstract
The invention discloses a method for preparing a preparation for treating habitual diarrhea from a traditional Chinese medicinal material pomelo fruit and application. The pomelo fruit is a new variety of traditional Chinese medicinal materials (Guangdong traditional Chinese medicinal material standard, 2011 edition), and is prepared by drying and processing young fruits of Mezhou pomelo. The invention belongs to the technical field of traditional Chinese medicine science. The invention discovers that the pomelo fruit and the preparation thereof can effectively treat the non-infectious (functional) habitual diarrhea disease, and develops new disease treatment application of the pomelo fruit and the preparation thereof. The medicinal effective component for treating the habitual diarrhea is the pomelo fruit and the medicinal preparation prepared from the pomelo fruit as a raw material. A preparation method of the pomelo fruit preparation comprises the following steps of crushing the pomelo fruit to obtain whole pomelo fruit powder, and mixing the whole pomelo fruit powder with pharmaceutic adjuvants to prepare tablets, capsules, dripping pills, sustained-release preparations and the like. Related experiments are carried out on the pomelo fruit and the preparation thereof, the effectiveness of treating the habitual diarrhea is proved, and the use is safe.
Description
technical field [0001] The invention relates to the field of traditional Chinese medicine science and technology, in particular to a method and application for preparing a preparation for treating habitual diarrhea from pomelo fruit, a Chinese medicinal material. Background technique [0002] Pomelo fruit, that is, the young fruit of Meizhou pomelo (harvested with a diameter of 3-7cm) is obtained by drying. It is a new type of high-quality Chinese medicinal material with the characteristics of Meizhou origin "Guangdong Provincial Standards of Traditional Chinese Medicinal Materials, 2011 Edition". [0003] According to traditional Chinese medicine, pomelo fruit has the functions of widening the middle and promoting Qi, invigorating the stomach and eliminating food. It can be used to treat symptoms such as indigestion and alcohol, cold pain in the abdomen, nausea and diarrhea. The main active ingredient of Meizhou pomelo fruit is naringin (content ≥ 20%), and other ingredie...
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