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Bone repair 3D printing material with low barium titanate content as well as preparation method and application of bone repair 3D printing material

A 3D printing, low barium titanate technology, applied in additive processing, prosthesis, tissue regeneration, etc., can solve problems such as high barium titanate addition is not conducive to bone tissue formation, low barium titanate content cannot achieve electrical activity, etc. , to achieve good biological activity

Pending Publication Date: 2021-05-11
STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of the existing bone repair material that the high addition of barium titanate is not conducive to the formation of bone tissue, and the low content of barium titanate cannot achieve the corresponding electrical activity, and provide a low barium titanate content that is still It has good electrical activity, promotes bone tissue growth and blood vessel formation, and is a 3D printing material for bone repair with good biosafety

Method used

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  • Bone repair 3D printing material with low barium titanate content as well as preparation method and application of bone repair 3D printing material
  • Bone repair 3D printing material with low barium titanate content as well as preparation method and application of bone repair 3D printing material
  • Bone repair 3D printing material with low barium titanate content as well as preparation method and application of bone repair 3D printing material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 A 3D printed scaffold for bone repair with low barium titanate content

[0048] The 3D printed scaffold for bone repair with low barium titanate content is made of the following materials and their weight percentages:

[0049] 5% of 10wt% hydroxypropyl methylcellulose aqueous solution, 1.7% of 10wt% polyethyleneimine aqueous solution, 7% of barium titanate, 63% of tricalcium phosphate, 2% of dispersant and the balance of water;

[0050] Stent design: Obtain the imaging data of the patient's bone defect, and design the shape of the defect after three-dimensional reconstruction.

[0051] Preparation:

[0052] S1. Prepare 10% w / w sodium diacetate aqueous solution, add tricalcium phosphate powder (particle size 300nm) and barium titanate (particle size 100nm) and mix evenly, then add 10% w / v hydroxypropyl methyl Aqueous cellulose solution and 10% w / v polyethyleneimine aqueous solution are mixed evenly to make the suspension into a gel to obtain a 3D printing slu...

Embodiment 2

[0056] Example 2 A 3D printed scaffold for bone repair with low barium titanate content

[0057] The 3D printed scaffold for bone repair with low barium titanate content is made of the following materials and their weight percentages:

[0058] 3.3% of 10wt% hydroxypropyl methylcellulose aqueous solution, 5% of 10wt% polyethyleneimine aqueous solution, 14% of barium titanate, 56% of tricalcium phosphate, 3% of dispersant and the balance of water;

[0059] Stent design: Obtain the imaging data of the patient's bone defect, and design the shape of the defect after three-dimensional reconstruction.

[0060] Preparation:

[0061] S1. Prepare 13% w / w sodium citrate aqueous solution, add tricalcium phosphate powder (particle size 300nm) and barium titanate (particle size 100nm) and mix evenly, then add 3.3% w / v hydroxypropyl methylcellulose in turn Mix plain aqueous solution and 5% w / v polyethyleneimine aqueous solution evenly to make the suspension into a gel, and then sonicate fo...

experiment example 1

[0074] Experimental example 1 Determination of appearance and surface morphology of stents with different additions of barium titanate

[0075] With reference to the parameters and preparation method of Example 1, change the ratio of tricalcium phosphate and barium titanate (tricalcium phosphate / barium titanate are respectively 10 / 0, 9 / 1, 8 / 2, 7 / 3) to prepare a stent, And determine the appearance and surface morphology of the stent, the results can be found in figure 1 .

[0076] Depend on figure 1 It can be seen that as the content of barium titanate (BT) in the system increases, the surface of the scaffold becomes smoother and the pores become less; this is because the BT particles are smaller and can fill the voids in the TCP particles, resulting in porosity on the surface of the scaffold Less, more even. In addition, the particle size of tricalcium phosphate (TCP) particles in the calcined scaffold also tended to decrease with the increase of BT content, which may be be...

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a bone repair 3D printing material with low barium titanate content and a preparation method and application of the bone repair 3D printing material. The material is prepared by combining hydroxypropyl methyl cellulose, polyethyleneimine, barium titanate, tricalcium phosphate, a dispersing agent and the like according to a certain proportion, on the premise of ensuring the piezoelectric property, the content (smaller than or equal to 40%) of BT in a TCP / BT material system can be greatly reduced, and better biological activity, osteogenesis performance and degradation performance are obtained. Effective stimulation is formed on functions of proliferation, differentiation and the like of cells under the synergistic effect of the LIPUS, and the bone defect repair process is actively intervened. Besides, prepared slurry can also be combined with a 3D printing technology, so that personalized requirements of different patients in clinical use are met, and a personalized TCP / BT bone repair material is prepared.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials. More specifically, it relates to a 3D printing material for bone repair with low barium titanate content and its preparation method and application. Background technique [0002] The repair of large bone defects has always been a difficult problem in clinical practice, and the reconstruction of defective bone tissue through tissue engineering is currently an ideal solution. Among them, tricalcium phosphate (TCP) has good biocompatibility, degradability and osteoinductive properties, and is an ideal scaffold material for bone tissue engineering; however, TCP has weak bioresponsiveness after implantation in the body, and it is difficult to complete large-scale bone tissue engineering. Repair of tissue defects. The electroactive material barium titanate has high piezoelectric properties and can form charges in response to mechanical stimuli. The charges on the surface of the material ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/58B33Y70/10
CPCA61L27/46A61L27/58B33Y70/10A61L2430/02C08L1/286C08L79/02
Inventor 周苗谌斯郭凯李树祎耿远明
Owner STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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