Zoledronic acid calcium complex and preparation method thereof
A technology of calcium zoledronate and zoledronic acid, which is applied in the field of biomedical materials, can solve problems such as adverse reactions and low concentration threshold, and achieves the effects of simple preparation method, moderate crystal growth rate and low stress
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[0018]Example 1
[0019]The purity of 98% (0.0082 g, 0.03 mmol) was weighed, a calcium chloride (0.0033 g, 0.03 mmol), which was 98%, added 10 ml of water, slowly dropped 0.1 mol / l NaOH solution, while The solution was stirred clear and transparent and adjusted pH to 4, and then transferred the solution to the Willin bottle, covered, tighted, and placed the Tilin bottle in the incubator, reacted at 20 ° C for 30 days, then filtered, washed, dried, The larger shape-regulated flatumn-transparent crystal is a calcium phosphonate complex. Among them, the reaction time and reaction temperature of the preparation process are negatively correlated. That is, the higher the temperature, the shorter the reaction time; the prepared zozole phosphonate compound is a flatumn-transparent crystal in the aqueous solution, and with the pH Rising, the rectangle is getting smaller and smaller.
[0020]figure 1 The optical micrograph of the calcium ferronicicate compound crystals, which can be seen from the...
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[0023]Example 2
[0024]The purity of 98% of the zozoic acid (0.0136 g, 0.05 mmol) was weighed, and the purity of 98% of calcium hydroxide (0.0074 g, 0.1 mmol) was added, and 10 ml of water was added, and the 0.1 mol / l NaOH solution was slowly added. The solution was stirred to clear the solution and adjusted pH to 4, and then transferred the solution into the Willin bottle, tighted, tightened, and placed the Willin bottle in the incubator, 20 days at 80 ° C, then filtered, washed, dried, The larger shape-regulated flatumn-transparent crystal is a calcium phosphonate complex.
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[0025]Example 3
[0026]The purity of 98% of the zozole phosphonic acid (0.0272 g, 0.1 mmol) was weighed, and the purity of 98% was calcium nitrate (0.0082 g, 0.05 mmol), and 10 ml of water was added, and the solution was slowly added to the 0.1 mol / l NaOH solution, and stirring The solution was clear and transparent and adjusted to 5, and then the solution was transferred to a 15 mL reaction kettle, tighted, tighted, and reacting the reaction kettle in the incubator, 7 days at 150 ° C, then filtered, washed, dried, A moderate shape-regulated flatumn-transparent crystal, is a calcium phosphonate complex.
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