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Triprolidine hydrochloride-containing oral solution and preparation method thereof

A technology of triprolidine hydrochloride and oral solution, applied in the field of pharmaceutical preparations, can solve the problems of inconvenience, short plasma half-life, reduced phenylephrine persistence, etc., and achieves a sweet taste with suitable sweet taste, controllable quality and low production cost. Effect

Pending Publication Date: 2021-05-28
NANJING GRITPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also conditions that require phenylephrine to have a sustained effect in the body, but due to the short plasma half-life of the active phenylephrine species in the body, phenylephrine is usually administered at intervals
Inconveniencing the patient and reducing the persistence of phenylephrine in the subject

Method used

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  • Triprolidine hydrochloride-containing oral solution and preparation method thereof
  • Triprolidine hydrochloride-containing oral solution and preparation method thereof
  • Triprolidine hydrochloride-containing oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Raw materials Dose (g) Triprolidine Hydrochloride 0.938 Dextromethorphan Hydrobromide 9.25 Phenylephrine Hydrochloride 4.56 glycerin 125 Propylene Glycol 235 Sorbitol 100 citric acid 1.9 Sodium citrate 1.0 stevia 0.2 Potassium sorbate 1.0 orange flavor 1.0 Maltitol liquid 0.6 purified water up to 1000ml

[0025] Preparation Process:

[0026] 1. Take purified water with 65% of the total volume of the oral liquid in the liquid preparation barrel, add the prescribed amount of sodium citrate and stir, then add the prescribed amount of triprolidine hydrochloride, dextromethorphan hydrobromide, and phenylephrine hydrochloride and stir to dissolve; After adding citric acid to dissolve completely, add stevioside and sorbitol in sequence and stir to dissolve, then add glycerin, propylene glycol, essence in turn, stir until the solution is clear, and finally add potassium sorbate and malt...

Embodiment 2

[0033] Raw materials Dose (g) Triprolidine Hydrochloride 0.5 Dextromethorphan Hydrobromide 4 Phenylephrine Hydrochloride 2 glycerin 125 Propylene Glycol 235 Sorbitol 100 citric acid 2.0 Sodium citrate 1.0 stevia 0.2 Potassium sorbate 1.0 strawberry flavor 1.0 Maltitol liquid 0.6 purified water up to 1000ml

[0034] 1. Take purified water with 65% of the total volume of the oral liquid in the liquid preparation barrel, add the prescribed amount of sodium citrate and stir, then add the prescribed amount of triprolidine hydrochloride, dextromethorphan hydrobromide, and phenylephrine hydrochloride and stir to dissolve; After adding citric acid to dissolve completely, add stevioside and sorbitol in sequence and stir to dissolve, then add glycerin, propylene glycol, essence in turn, stir until the solution is clear, and finally add potassium sorbate and maltitol solution and stir to dissolve;...

Embodiment 3

[0041] Raw materials Dose (g) Triprolidine Hydrochloride 0.938 Dextromethorphan Hydrobromide 9.25 Phenylephrine Hydrochloride 4.56 glycerin 250 Propylene Glycol 235 Sorbitol 100 citric acid 1.9 Sodium citrate 1.0 Sucralose 0.2 Methylparaben 0.1 Propylparaben 0.1 strawberry flavor 1.0 Maltitol liquid 0.6 purified water up to 1000ml

[0042]1. Take purified water with 65% of the total volume of the oral liquid in the liquid preparation barrel, add the prescribed amount of sodium citrate and stir, then add the prescribed amount of triprolidine hydrochloride, dextromethorphan hydrobromide, and phenylephrine hydrochloride and stir to dissolve; After adding citric acid to dissolve completely, add stevioside and sorbitol in sequence and stir to dissolve, then add glycerin, propylene glycol, essence in turn, stir until the solution is clear, and finally add potassium sorbate and maltitol ...

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PUM

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a compound oral solution preparation containing triprolidine. According to the compound triprolidine hydrochloride oral solution, pharmaceutically acceptable auxiliary materials are used, a dosage is accurately divided, and medication safety is improved; an aromatic and a sweetening agent are added, so the mouth feel of the solution is good; and the dosage is accurately divided by using a graduated dropper, so the compound triprolidine hydrochloride oral solution is particularly suitable for children. The compound triprolidine hydrochloride oral solution disclosed by the invention is controllable in quality, high in stability, simple in process, easy to absorb and exact in curative effect, and can better meet clinical requirements.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound oral solution preparation containing triprolidine. Background technique [0002] Allergic diseases are generally characterized by immediate allergic reactions, also known as type I allergic reactions, which mainly cause allergic rhinitis, asthma, conjunctivitis, eczema, food allergies, drug allergies, and severe allergic reactions. In the past few decades, the incidence of allergic diseases has increased significantly, which has seriously affected the quality of life of children and adults, and even endangered their lives. It has become a public health issue of global concern. [0003] Immunoglobulin E (IgE) is an antibody that mediates type I allergic reactions. There are two types of IgE receptors in the human body: the high-affinity receptor FcεRI and the low-affinity receptor FcεRII, the former expressed in mast cells and basophils, the latter expressed ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/4439A61K31/137A61K9/08A61P37/08A61P11/02A61P11/06A61P27/02A61P17/00
CPCA61K31/4439A61K31/485A61K31/137A61K9/08A61K9/0053A61P37/08A61P11/02A61P11/06A61P27/02A61P17/00A61K2300/00
Inventor 耿聪聪芦彩萍陆滢炎朱丽君吴小涛赵卿霍立茹李战
Owner NANJING GRITPHARMA CO LTD
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