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A preparation for the treatment of contact dermatitis

A contact dermatitis and preparation technology, applied in the field of preparations for the treatment of contact dermatitis, can solve problems such as increased hair growth, spots, and antibiotic resistance, and achieve the effects of inhibiting TF expression, improving slow blood flow, and restoring circulation

Active Publication Date: 2022-02-01
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, glucocorticoid drugs may cause burning and tingling sensations, and long-term external use may also cause side effects such as skin thinning or color changes, spots, and increased hair growth, and antibiotics may also cause side effects such as tolerance
[0005] Based on the above pathological characteristics and previous research results, we found that paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid and ginsenoside can inhibit inflammation by inhibiting the TLR4-MMP9 inflammatory pathway on the one hand, and on the other hand can inhibit inflammation by inhibiting PAR2 -TF improves circulation, but currently there is no drug that combines these materials for anti-inflammatory expansion, repair and improvement of circulation, and rose essential oil, paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid, and ginsenosides have been rationally proportioned, In order to achieve enhanced anti-inflammatory repair effect, it has a good effect on alcohol contact dermatitis

Method used

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  • A preparation for the treatment of contact dermatitis
  • A preparation for the treatment of contact dermatitis
  • A preparation for the treatment of contact dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Selection of raw materials: the impurity contents in paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid and ginsenoside are all less than or equal to 1 wt%.

[0036] Prepare the hand cream as follows:

[0037] (A) According to 0.08wt% of paeoniflorin, 0.7wt% of resveratrol, 0.5wt% of proanthocyanidins, 0.1wt% of glycyrrhizic acid, 0.08wt% of ginsenoside, and the balance is the external drug matrix to take raw materials for later use;

[0038] (B) adopt emulsifying agent to prepare conventional cream, after being cooled to room temperature, standby;

[0039] (C) Add paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid and ginsenoside into the cream, mix with a homogenizer and sterilize to obtain the preparation.

Embodiment 2

[0040] Example 2: Selection of raw materials: The impurity contents in paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid and ginsenoside are all less than or equal to 1 wt%.

[0041] Prepare the hand cream as follows:

[0042] (A) According to 0.04wt% of paeoniflorin, 0.2wt% of resveratrol, 0.1wt% of proanthocyanidins, 0.02wt% of glycyrrhizic acid, 0.01wt% of ginsenoside, and the balance is the external drug base to weigh the raw materials for later use;

[0043] (B) adopt emulsifying agent to prepare conventional emulsion, after being cooled to room temperature, standby;

[0044] (C) Add paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid and ginsenoside into the emulsion, mix with a homogenizer and sterilize to obtain the preparation.

Embodiment 3

[0045]Example 3: Selection of raw materials: The impurity contents in paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid and ginsenoside are all less than or equal to 1 wt%.

[0046] Prepare the hand cream as follows:

[0047] (A) According to 0.12wt% of paeoniflorin, 0.12wt% of resveratrol, 0.9wt% of proanthocyanidins, 0.14wt% of glycyrrhizic acid, 0.15wt% of ginsenoside, and the balance is the external drug matrix to take raw materials for later use;

[0048] (B) Prepare the gel matrix by using carbomer powder, cool to room temperature and set aside;

[0049] (C) Add paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid and ginsenoside into the gel matrix, mix with a homogenizer and sterilize to obtain the preparation.

[0050] The pharmaceutical properties of each raw material are as follows:

[0051] Paeoniflorin has the effects of resisting oxidative stress damage of tissue cells, inhibiting the activation of astrocytes, and enhancing nerve protec...

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Abstract

The invention discloses a preparation for treating contact dermatitis, relates to the field of pharmaceutical preparations for external use, and comprises the following components in mass fractions: 0.04-0.12 wt% of paeoniflorin, 0.2-0.12 wt% of resveratrol, and 0.1-0.12 wt% of proanthocyanidin 0.9wt%, glycyrrhizic acid 0.02-0.14wt%, ginsenoside 0.01-0.15wt%, and the rest is external drug matrix. Aiming at the pathological mechanism of alcohol contact dermatitis, the present invention makes a hand cream by rationally mixing paeoniflorin, resveratrol, proanthocyanidins, glycyrrhizic acid and ginsenoside, and then up-regulates the expression of SOCS3 through the GAS6‑AXL pathway on the one hand Play an anti-inflammatory effect, on the other hand, inhibit TF expression, improve slow blood flow, restore circulation, and play an anti-inflammatory and repairing effect. It has a definite curative effect on alcohol contact dermatitis and a clear mechanism.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations for external use, in particular to a preparation for treating contact dermatitis. Background technique [0002] Alcohol contact dermatitis refers to a series of skin adverse reactions caused by prolonged skin contact with alcohol, which belongs to irritant contact dermatitis. It often occurs on exposed parts of the body. In mild cases, erythema, edema, papules and other manifestations may occur. In severe cases, the skin lesions may have erosion, exudation, or even necrosis, often accompanied by itching. It is a problem often encountered in daily life. Some people, such as medical staff, have "alcohol hands" due to prolonged contact with alcohol disinfection, eczema and peeling of hands. Contact dermatitis is usually confined to the site of direct skin contact with the irritant and generally does not or rarely extends beyond its boundaries. Acute contact dermatitis can be cured within ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61K31/7048A61K31/353A61K31/704A61K36/258A61K9/06A61P17/00
CPCA61K31/7048A61K31/05A61K31/353A61K31/704A61K36/258A61K9/06A61K9/0014A61P17/00A61K2300/00
Inventor 刘文涛唐玉林刘煜王超钰林彤彤姜春懿胡亮王玉田田吴雪丰
Owner NANJING MEDICAL UNIV
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