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Material with biological anti-pollution function as well as preparation method and application thereof

A functional and biological technology, applied in the field of materials with biological antifouling function, can solve the problem of poor blood compatibility, inability to effectively inhibit cell adhesion and proliferation, and restrict the safe application and therapeutic effect of inferior vena cava filters and central venous catheters, etc. problems, achieve the effect of inhibiting thrombus formation, reducing operation failure and complications

Pending Publication Date: 2021-05-28
CHENGDU JIAODA MEDICAL SCI & TECH COMPANY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional antibiotics face the risk of drug resistance, and the use of anticoagulants may lead to complications such as thrombocytopenia and systemic bleeding
[0005] It can be seen that the existing inferior vena cava filter has poor blood compatibility and cannot effectively inhibit cell adhesion and proliferation, while the existing central venous catheter and other devices rely on the clinical side effects caused by the systemic use of anticoagulant drugs and antibiotics. , all restrict the safe application and therapeutic effect of inferior vena cava filter and central venous catheter to a certain extent

Method used

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  • Material with biological anti-pollution function as well as preparation method and application thereof
  • Material with biological anti-pollution function as well as preparation method and application thereof
  • Material with biological anti-pollution function as well as preparation method and application thereof

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preparation example Construction

[0024] The embodiment of the present invention also provides a preparation method of a material with biological antifouling function, please refer to figure 1 , including the following steps:

[0025] S1, the formation of poly(phenol-amine) coating

[0026] Dissolve polyphenolic compounds with carboxyl functional groups and polyamine molecules in the carbodiimide reaction system, and covalently modify polyphenolic compounds with carboxyl functional groups on the side chains of polyallylamine molecules through condensation reaction for 6-24 hours , to construct a polyamine-based adhesion molecule modified with a polyphenolic compound; then, the obtained polyamine-based adhesion molecule modified with a polyphenolic compound was dissolved in water, and the surface was formed by oxidative polymerization under alkaline conditions to form a surface rich in amino groups. The poly(phenol-amine) coating can be easily introduced into other functionalized coatings.

[0027] Specifical...

Embodiment 1

[0039] This embodiment provides a method for preparing a material with biological antifouling function, comprising the following steps:

[0040] (1) Dissolve hydrocaffeic acid and polyallylamine (molecular weight about 10000Da) in 2-(N-morpholine)ethanesulfonic acid (MES), 1-ethyl-3-(3-dimethylaminopropyl Base) carbodiimide (EDC) and N-hydroxysuccinamide (NHS) in the solution (pH 5.6) composition reaction, control the concentration of hydrocaffeic acid, polyallylamine, MES, EDC and NHS to be 0.5mg / mL , 5mg / mL, 9.76mg / mL, 1mg / mL, 0.24mg / mL. After reacting for 12 hours, polyamine-based adhesion molecules modified by polyphenol compounds (marked as HCAPA) were obtained.

[0041] (2) Place the inferior vena cava filter in a Tris (pH 8.5) buffer solution containing 5 mg / mL of HCAPA, react at room temperature for 12 hours, and obtain a layer of amine-rich coating on the surface of the inferior vena cava filter (marked as PHCAPA).

[0042] (3) Mix MES, EDC, NHS, hyaluronic acid (m...

Embodiment 2

[0044] This embodiment provides a method for preparing a material with biological antifouling function, comprising the following steps:

[0045] (1) Dissolve hydrocaffeic acid and polyallylamine (molecular weight about 10000Da) in 2-(N-morpholine)ethanesulfonic acid (MES), 1-ethyl-3-(3-dimethylaminopropyl Base) carbodiimide (EDC) and N-hydroxysuccinamide (NHS) in the solution (pH 5.6) composition reaction, control the concentration of hydrocaffeic acid, polyallylamine, MES, EDC and NHS to be 0.5mg / mL , 5mg / mL, 9.76mg / mL, 1mg / mL and 0.24mg / mL. After reacting for 12 hours, polyamine-based adhesion molecules modified by polyphenol compounds (marked as HCAPA) were obtained.

[0046] (2) The central venous catheter is then placed in a Tris (pH value 8.5) buffer solution containing 5 mg / mL of HCAPA, and reacted at room temperature for 12 hours, that is, a layer of amine-rich coating is obtained on the surface of the central venous catheter (marked as PHCAPA).

[0047] (3) Mix MES...

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Abstract

The invention discloses a material with a biological anti-pollution function as well as a preparation method and application thereof, and relates to the technical field of biological materials. The functional material for biological decontamination comprises a base material, a poly(phenol-amine) coating layer and a super-hydrophilic coating layer, wherein the poly(phenol-amine) coating layer and the super-hydrophilic coating layer are formed on the base material, wherein the poly(phenol-amine) coating layer is obtained by reacting a polyphenol compound containing carboxyl and polyamine macromolecules. The preparation method comprises the steps: forming the poly(phenol-amine) adhesion coating layer on the base material by utilizing a phenol-amine chemical coating technology, and then covalently grafting hyaluronic acid by utilizing amido on the poly(phenol-amine) adhesion coating layer to form a hyaluronic acid coating layer. When the coating layer is in contact with water, a hydration layer is formed on the surface of the coating layer, and a super-hydrophilic surface is formed, so that adhesion, migration and proliferation of components, endothelial cells, smooth muscle cells, inflammatory cells and the like in blood are effectively inhibited; therefore, the material or instrument with the biological anti-pollution function, such as an inferior vena cava filter or a central venous catheter or an artificial heart auxiliary pump with a recyclable function, can be prepared.

Description

technical field [0001] The invention relates to the technical field of biological materials, and in particular to materials with biological antifouling functions, their preparation methods and applications. Background technique [0002] Pulmonary embolism is a disease with a high clinical mortality rate. Although the current systemic anticoagulant therapy can achieve a certain effect, it still cannot completely avoid the occurrence of pulmonary embolism, and systemic anticoagulant therapy itself will have complications, and some patients Unable to accept systemic anticoagulant therapy. As a preventive method for pulmonary embolism, inferior vena cava filter has been widely used all over the world. With the widespread clinical use, some corresponding complications also appeared, which made the filter treatment fail and even lead to the death of the patient. [0003] During the implantation of the inferior vena cava filter, the surgical operation will cause damage to the bloo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/14A61L29/08A61L31/14A61L31/10
CPCA61L29/14A61L29/085A61L31/14A61L31/10C08L87/00C08L79/02
Inventor 黄楠杨作霞钟永英
Owner CHENGDU JIAODA MEDICAL SCI & TECH COMPANY
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