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Preparation and application of ketorolac patch

A technology of ketorolac and patches, applied in the field of preparation and application of ketorolac patches, can solve problems such as dose dumping, impact on use and promotion, difficulties in preparation of storage-type patches, etc., and achieve painless administration, Improve medication compliance and reduce gastrointestinal side effects

Pending Publication Date: 2021-06-04
CHANGSHA JINGYI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of reservoir-type patches is more difficult, and there is a risk of dose dumping
The above preparations have affected the clinical use and promotion of the drug to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: solvent-based patch

[0045] Prescription composition:

[0046] components Prescription ratio (mg / g) effect Ketorolac 25 active ingredient Acrylic pressure sensitive adhesive (DURO-TAK 129A) 875 solvent base Propylene Glycol 50 Skin penetration enhancer Isopropyl myristate 30 Skin penetration enhancer Butylated hydroxytoluene 20 preservative

[0047] Preparation process: Dissolve ketorolac and dibutyl hydroxytoluene in propylene glycol and isopropyl myristate, and mix well. Then add it to the acrylate pressure sensitive adhesive solution (DURO-TAK 129A) and mix well. The above mixture is coated on the backing layer, dried, and then attached to the protective layer, and cut into the required size to obtain the ketorolac solvent-based patch.

Embodiment 2

[0048] Embodiment 2: solvent-based patch

[0049] Prescription composition:

[0050] components Prescription ratio (mg / g) effect Ketorolac 50 active ingredient Acrylic pressure sensitive adhesive (DURO-TAK 129A) 850 solvent base Propylene Glycol 50 Skin penetration enhancer Isopropyl myristate 30 Skin penetration enhancer Butylated hydroxytoluene 20 preservative

[0051] Preparation process: Dissolve ketorolac and dibutyl hydroxytoluene in propylene glycol and isopropyl myristate, and mix well. Then add it to the acrylate pressure sensitive adhesive solution (DURO-TAK 129A) and mix well. The above mixture is coated on the backing layer, dried, and then attached to the protective layer, and cut into the required size to obtain the ketorolac solvent-based patch.

Embodiment 3

[0052] Embodiment 3: hot-melt patch

[0053] Prescription composition:

[0054] components Prescription ratio (mg / g) effect Ketorolac 25 active ingredient SIS 200 hot melt matrix polyisobutylene 100 hot melt matrix Terpene resin 300 Tackifier liquid paraffin 300 plasticizer Isopropyl myristate 30 Skin penetration enhancer Diisopropyl adipate 20 Skin penetration enhancer Butylated hydroxytoluene 25 preservative

[0055] Preparation process: dissolve ketorolac in ethanol, melt and knead all the ingredients at a temperature of 120-160°C, coat it on the backing layer, then stick the protective layer, and cut it into the required size to obtain the ketone Rolic acid hot-melt patch.

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PUM

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Abstract

The invention discloses preparation and application of a ketorolac patch. The patch comprises an active component, a matrix material and other pharmaceutically acceptable external preparation auxiliary materials, wherein the matrix material comprises a hot melt type matrix material and a solvent type matrix material; the the content of ketorolac accounts for 0.1%-10.0% of the total weight of the patch. The ketorolac patch can be used for treating or relieving moderate to severe pains of various muscles, soft tissues and joints. The ketorolac patch has the advantages that the ketorolac patch is convenient to use, small in side reaction and high in safety, takes effect for a long time, and can improve the medication compliance of patients.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to the preparation and application of a ketorolac patch. Background technique [0002] Ketorolac is a non-steroidal antipyretic and analgesic drug, which exerts analgesic and anti-inflammatory effects by inhibiting the synthesis of prostaglandins, and can be used to relieve a variety of moderate to severe acute pain and postoperative pain. It mainly acts on peripheral cyclooxygenase receptors, has no effect on the central nervous system, and will not produce addiction. [0003] Currently marketed dosage forms containing ketorolac include oral preparations, injections, and eye drops. However, due to the rapid metabolism of ketorolac in the body, oral preparations and injections need to be used continuously, resulting in serious gastrointestinal side effects and low patient compliance. In addition, the eye drops themselves cannot strictly control the dosage of each adminis...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/407A61K47/32A61P29/00
CPCA61K9/7053A61K9/7061A61K31/407A61P29/00
Inventor 张海龙
Owner CHANGSHA JINGYI PHARM TECH CO LTD