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Preparation method of medicine composition containing levamlodipine and candesartan cilexetil

A technology for candesartan medoxomil and a composition is applied in the field of preparation of pharmaceutical compositions and can solve the problems of poor powder fluidity, large differences in splinter and tablet weight and the like

Inactive Publication Date: 2021-06-08
HAINAN JINRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The embodiment of the present application provides a preparation method of a pharmaceutical composition containing levamlodipine and candesartan cilexetil, which is used to solve the existing powder direct compression method to prepare a drug containing levamlodipine and candesartan cilexetil Composition, there are technical problems of poor powder fluidity, large difference in tablet weight, and easy cracking caused by powder compression

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  • Preparation method of medicine composition containing levamlodipine and candesartan cilexetil

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Embodiment 1

[0032] For ease of understanding, see figure 1 , an embodiment of the preparation method of the pharmaceutical composition containing levamlodipine and candesartan cilexetil provided by the application, comprising the following steps:

[0033]S1: The auxiliary materials sorbitol, dry starch, natural clay magnesium aluminum silicate and croscarmellose sodium were mixed in a mixer to obtain the first disintegrant. The mixing time was 30 minutes. The auxiliary materials sorbitol, dry The mass ratio of starch, natural clay magnesium aluminum silicate and croscarmellose sodium is 1:6:0.8:0.3;

[0034] S2: Put levamlodipine besylate, candesartan cilexetil, filler, binder and first disintegrant into a pulverizer for pulverization, and the filler is the mass ratio of lactose and calcium hydrogen phosphate It is a mixture of 5:3, the binder is a mixture of syrup, dextrin and highly substituted hydroxypropyl cellulose, and the mass ratio of syrup, dextrin and highly substituted hydroxy...

Embodiment 2

[0041] The preparation method of the pharmaceutical composition containing levamlodipine and candesartan cilexetil comprises the following steps:

[0042] S1: The auxiliary materials sorbitol, dry starch, natural clay magnesium aluminum silicate and croscarmellose sodium were mixed in a mixer to obtain the first disintegrant. The mixing time was 30 minutes. The auxiliary materials sorbitol, dry The mass ratio of starch, natural clay magnesium aluminum silicate and croscarmellose sodium is 1:6:0.8:0.3;

[0043] S2: Put levamlodipine besylate, candesartan cilexetil, filler, binder and first disintegrant into a pulverizer for pulverization, and the filler is the mass ratio of lactose and calcium hydrogen phosphate It is a mixture of 5:3, the binder is a mixture of syrup, dextrin and highly substituted hydroxypropyl cellulose, and the mass ratio of syrup, dextrin and highly substituted hydroxypropyl cellulose is 1:0.3:0.8;

[0044] S3: adding the pulverized raw and auxiliary mate...

Embodiment 3

[0050] The preparation method of the pharmaceutical composition containing levamlodipine and candesartan cilexetil comprises the following steps:

[0051] S1: The auxiliary materials sorbitol, dry starch, natural clay magnesium aluminum silicate and croscarmellose sodium were mixed in a mixer to obtain the first disintegrant. The mixing time was 20 minutes. The auxiliary materials sorbitol, dry The mass ratio of starch, natural clay magnesium aluminum silicate and croscarmellose sodium is 1:6:0.8:0.3;

[0052] S2: Put levamlodipine besylate, candesartan cilexetil, filler, binder and first disintegrant into a pulverizer for pulverization, and the filler is the mass ratio of lactose and calcium hydrogen phosphate It is a mixture of 5:3, the binder is a mixture of syrup, dextrin and highly substituted hydroxypropyl cellulose, and the mass ratio of syrup, dextrin and highly substituted hydroxypropyl cellulose is 1:0.3:0.8;

[0053] S3: adding the pulverized raw and auxiliary mate...

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Abstract

The invention discloses a preparation method of a medicine composition containing levamlodipine and candesartan cilexetil. Through technology improvement and formula sequence optimization, the hydrothermal stability problem of the medicine composition, which is produced by wet granulation, containing the levamlodipine and the candesartan cilexetil can be avoided, and meanwhile, the defects that powder liquidity is poor, a tablet weight difference is big, powder tableting is likely to cause a broken tablet and the like in a finished product during powder direct tableting can be effectively overcome. The preparation method is favorable for guaranteeing the stability and the tableting shaping efficiency of the medicine composition containing the levamlodipine and the candesartan cilexetil, in addition, the medicine composition containing the levamlodipine and the candesartan cilexetil has short disintegration time and good dissolution uniformity, so that the medicine is quick to take effects and is quick in absorption, and the bioavailability of the medicine can be increased. By use of the preparation method disclosed by the invention, the technical problems in the medicine composition, which is prepared by an existing powder direct tableting method, containing levamlodipine and candesartan cilexetil that the powder liquidity is poor, the tablet weight difference is big and the powder tableting is likely to cause the broken tablet can be solved.

Description

technical field [0001] The application relates to the technical field of medicine, in particular to a preparation method of a pharmaceutical composition containing levamlodipine and candesartan cilexetil. Background technique [0002] With the continuous development of society, people's living standards and work rhythm are constantly accelerating, and the number of patients with cardiovascular and cerebrovascular diseases is also increasing. Cardiac ischemia or hemorrhage caused by arterial hardening, including coronary heart disease, angina pectoris, hypertension, arrhythmia, myocardial infarction, cerebral infarction and other symptoms. Cardiovascular and cerebrovascular diseases have always threatened human health. Hypertension, hyperlipidemia, coronary heart disease and diabetes have become "the plague of the times". [0003] According to statistics, among people over the age of 60, 40% to 45% suffer from high blood pressure and high blood fat, and about 50% of diabetic...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/4184A61K9/28A61K47/38A61K47/36A61K47/26A61K47/02A61P9/12A61P9/00
CPCA61K31/4422A61K31/4184A61K9/2018A61K9/2059A61K9/2009A61K9/2054A61K9/2095A61K9/2806A61P9/12A61P9/00
Inventor 黄月娜王进宇潘淑华王寿春王小芳
Owner HAINAN JINRUI PHARMA