Chitosan-gallic acid graft copolymer as well as preparation method and application thereof

A technology of graft copolymer and gallic acid, which is applied in the field of chitosan-gallic acid graft copolymer, can solve the problems of complex operation, unsatisfactory grafting rate, and environmental pollution, and achieve high grafting rate and excellent antibacterial , the effect of simple equipment

Active Publication Date: 2021-06-15
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, chemical coupling method and enzyme catalysis method are mainly used to prepare polysaccharides grafted with phenolic acid compounds, but chemical crosslinking agents and organic solvents are required, resulting in complicated operation, environmental pollution, and unsatisfactory grafting rate

Method used

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  • Chitosan-gallic acid graft copolymer as well as preparation method and application thereof
  • Chitosan-gallic acid graft copolymer as well as preparation method and application thereof
  • Chitosan-gallic acid graft copolymer as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] A preparation method of chitosan (CS) surface grafted gallic acid (GA):

[0040](1) Weigh 1g of chitosan and 1.05g of gallic acid (PAR=1.0) in a 250mL three-necked bottle, stir and dissolve with 100mL of 1% hydrochloric acid / water solution (v / v), adjust with 0.1mol / L sodium hydroxide solution The pH is 3. Nitrogen (3L / min), with copper as the cathode, fix the copper at the bottom of the there-necked bottle, use the tungsten rod as the anode, soak the tungsten rod to the position 1cm below the liquid surface, after the power is turned on, the discharge voltage is 9kV , 0.5A discharge current for 20min discharge (without stirring). After the discharge was completed, the reaction bottle was transferred to a constant temperature oil bath at 85° C. to continue the polymerization reaction for 3 h.

[0041] (2) Ultrapure water dialysis (MWCO: 14000 Da) for 48 hours to remove gallic acid not grafted onto chitosan, and freeze-drying to obtain gallic acid / chitosan graft copolym...

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Abstract

The invention belongs to the technical field of material science, and particularly relates to a chitosan-gallic acid grafted copolymer as well as a preparation method and application thereof. The preparation method at least comprises the following steps: (1) carrying out low-temperature liquid-phase discharge plasma treatment on a mixed solution containing gallic acid and chitosan, wherein the discharge voltage of the low-temperature liquid-phase discharge plasma treatment is 8.5-9.5 kV; and (2) carrying out a post-polymerization reaction on the mixed solution having been subjected to low-temperature liquid-phase discharge plasma treatment. According to the method, a chemical cross-linking agent and an organic solvent are not used in the reaction process, meanwhile, the grafting rate of phenolic acid is high, green and environment-friendly effects are achieved, equipment is simple, and operation is convenient. The chitosan-gallic acid grafted copolymer prepared by the method has excellent antibacterial and wound healing accelerating capabilities, and can be widely applied as a rapid hemostatic sealant.

Description

technical field [0001] The invention belongs to the technical field of material science, and in particular relates to a chitosan-gallic acid graft copolymer and its preparation method and application. Background technique [0002] Polysaccharides are sugar chains bound by glycosidic bonds, and can be divided into homogeneous polysaccharides and heterogeneous polysaccharides. The most abundant homogeneous polysaccharides in nature are starch, glycogen and cellulose, and the common heterogeneous polysaccharides include hyaluronic acid and chondroitin sulfate. Because polysaccharides have many excellent characteristics such as biodegradability, biocompatibility, and ability to improve the immune activity of the body, they have received extensive attention in various fields. Compounding polysaccharides and other bioactive substances can give them more value. [0003] Phenolic acid compounds are a class of secondary metabolites widely present in plants, which have strong antioxi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K31/192A61K31/722A61K47/55A61P7/04A61P17/02A61P31/04
CPCC08B37/003A61K31/722A61K31/192A61K47/55A61P7/04A61P17/02A61P31/04A61K2300/00
Inventor 赵彦兵孙承园聂兰兰李志宇
Owner HUAZHONG UNIV OF SCI & TECH
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