Nanofiber-based microsphere composite membrane and preparation method thereof

A nanofiber and composite membrane technology, applied in textiles, papermaking, non-woven fabrics, etc., can solve the problems of limited development, poor mechanical properties of microspheres, agglomeration, etc., achieve high economic and time benefit advantages, and easy to promote industrialization. , the effect of excellent biocompatibility

Inactive Publication Date: 2021-06-18
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Biomimetic porous microsphere tissue engineering scaffold as described in Chinese Invention Patent Application No. 200910243568.5, but the particle size of the microspheres in this patent ranges from 100 to 500 μm, which is not conducive to cell proliferation and adhesion on its surface; such as Chinese Invention Patent Application No. Antibacterial composite microspheres described in 201710265534.0, but the mechanical properties of the microspheres in this patent are not good, which limits the development of its biomedical materials. At the same time, traditional microsphere preparation methods such as emulsification precipitation, cross-linking and spray drying , not only the process is complicated, there are many by-products, the uniformity of the prepared microspheres is difficult to control and lacks, but also the phenomenon of agglomeration is almost inevitable

Method used

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  • Nanofiber-based microsphere composite membrane and preparation method thereof
  • Nanofiber-based microsphere composite membrane and preparation method thereof
  • Nanofiber-based microsphere composite membrane and preparation method thereof

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preparation example Construction

[0030] The purpose of the present invention is to provide a method for preparing a nanofiber-based microsphere composite membrane, which rapidly prepares a composite membrane in which microspheres and nanofibers coexist by using electrospinning technology. The solution components for electrospinning are one or more of polymers such as polycaprolactone, polylactic acid, polyvinyl alcohol, polystyrene, silk fibroin, wool protein, chitosan and collagen. Specific steps are as follows:

[0031] (1) Preparation of electrospinning solution

[0032] Slowly pour 1 to 10 g of polycaprolactone (Polycaprolactone, PCL) with an average molecular weight of 30,000 to 80,000 into 50 to 200 mL of chloroform (CHCl 3 ) at 20-30°C at a speed of 800-2000 rpm for 3-6 hours until completely dissolved. Then use an ultrasonic disperser, with an amplitude of 10-40%, ultrasonically disperse for 3-30 minutes to disperse evenly, and then place it in an oven at a temperature of 35-55°C to defoam for 1-30 ...

Embodiment 1

[0040] This implementation case shows a "one-step method" to efficiently prepare a composite film with uniform distribution of nanofibers and microspheres through high-voltage electrospinning technology. The steps are as follows:

[0041] (1) Preparation of electrospinning solution

[0042]Slowly pour 1-10 g of polycaprolactone (Polycaprolactone, PCL) with an average molecular weight of 5000-50000 into 50-200 mL of chloroform (CHCl 3 ) at 20-30°C at a speed of 800-2000 rpm for 3-6 hours until completely dissolved. Then use an ultrasonic disperser, with an amplitude of 10-40%, ultrasonically disperse for 3-30 minutes to disperse evenly, and then place it in an oven at a temperature of 35-55°C to defoam for 1-30 minutes under dark and sealed conditions. After 12 hours, a PCL solution with a mass fraction of 5-12% was obtained for use.

[0043] (2) Electrospinning

[0044] Prepare the nanofiber-based microsphere composite film by high-voltage electrospinning technology; put th...

Embodiment 2

[0048] This implementation case shows a "one-step method" to efficiently prepare a composite film with uniform distribution of nanofibers and microspheres through high-voltage electrospinning technology. The steps are as follows:

[0049] (1) Preparation of electrospinning solution

[0050] Slowly pour 1-10 g of polycaprolactone (Polycaprolactone, PCL) with an average molecular weight of 5000-50000 into 50-200 mL of chloroform (CHCl 3 ) at 20-30°C at a speed of 800-2000 rpm for 3-6 hours until completely dissolved. Then use an ultrasonic disperser, with an amplitude of 10-40%, ultrasonically disperse for 3-30 minutes to disperse evenly, and then place it in an oven at a temperature of 35-55°C to defoam for 1-30 minutes under dark and sealed conditions. After 12 hours, a PCL solution with a mass fraction of 12-20% was obtained for use.

[0051] (2) Electrospinning

[0052] Prepare the nanofiber-based microsphere composite film by high-voltage electrospinning technology; put ...

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Abstract

The invention discloses a preparation method of a nanofiber-based microsphere composite membrane. The preparation method comprises the following steps: preparing an electrostatic spinning solution, obtaining the nanofiber-based microsphere composite membrane by adopting an electrostatic spinning technology, soaking the nanofiber-based microsphere composite membrane in absolute ethyl alcohol, taking out the nanofiber-based microsphere composite membrane, naturally drying the nanofiber-based microsphere composite membrane, removing the redundant solvent, and then drying the nanofiber-based microsphere composite membrane in a vacuum drying oven to obtain the nanofiber-based microsphere composite membrane. According to the membrane, the problems that microspheres are prone to agglomeration and poor in mechanical property can be solved through the formation of the nanofibers, and the problems that the nanofibers are high in degradation speed, low in drug loading capacity and high in drug slow release speed can be solved through the formation of the microspheres. Besides, the nanofiber-based microsphere composite membrane can simulate an extracellular matrix with a nanoscale filamentous interlaced structure, tissue repair and regeneration are facilitated, and the structure can endow the composite membrane with good mechanical properties.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing a composite structure membrane material in which nanofibers and microspheres coexist. Background technique [0002] Nanofibers refer to linear materials with a diameter on the nanometer scale and a large aspect ratio. They can not only be used as materials for noise reduction and filtration, but also be used in biomedical fields such as tissue engineering scaffolds, medical dressings, and drug carriers. . At present, the common technology used for the preparation of nanofibers is electrospinning, and its raw materials can be divided into natural polymers such as silk fibroin, cellulose, collagen and chitosan, etc., artificially synthesized polymers such as polyethylene Alcohol, polycaprolactone and polylactic acid, etc. For example, China Invention Patent Application No. 201910497175.0, a chitosan-based drug-loaded nanofiber film applied to medical wou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/4382D04H1/435D04H1/413
CPCD04H1/728D04H1/4382D04H1/435D04H1/413
Inventor 李刚冯裕胜
Owner SUZHOU UNIV
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