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Policosanol microcapsule and preparation method and application thereof

A technology for priol and microcapsules, applied in the field of priitol microcapsules and their preparation, can solve problems such as poor water solubility, inability to meet production requirements, unsuitable materials, etc., achieve good water solubility and dispersibility, and improve bioavailability rate, reducing the effect of potential damage

Active Publication Date: 2021-06-22
INST OF BIOLOGICAL RESOURCES JIANGXI ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A number of studies have shown that pliol has unique physiological functions such as enhancing endurance, anti-fatigue, lowering blood fat, anti-inflammation, and protecting the liver. However, its poor water solubility and low bioavailability restrict its application in health food and medicine
[0003] Aiming at the problem of poor water solubility of pliol, the publication number is CN1316966C using gum arabic, β-hydroxypropyl cyclodextrin and maltose as wall materials to prepare pliol , although the water solubility of pliol is improved, however, the materials used are not suitable for diabetic patients and the preparation process is old, which cannot meet the requirements of modern industrial production
At present, there is a lack of a universal pliol microcapsule while solving the problem of poor water solubility of pliol

Method used

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  • Policosanol microcapsule and preparation method and application thereof
  • Policosanol microcapsule and preparation method and application thereof

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preparation example Construction

[0026] The present invention also provides a preparation method for the above-mentioned pliol microcapsules, comprising the following steps:

[0027] (1) After mixing and emulsifying pliol, emulsifier and water, perform dynamic high-pressure micro-jet treatment to obtain a nanoemulsion;

[0028] (2) After embedding the mixture of the nanoemulsion and sulfobutyl ether-beta-cyclodextrin, hydrophilic colloid and oligosaccharide, carry out secondary dynamic high-pressure micro-jet treatment to obtain a microcapsule emulsion; the microcapsule The pliol microcapsules are obtained after the emulsion is dried.

[0029] In the present invention, the mixing and emulsification of the pliol, emulsifier and water preferably includes the following steps: mixing and heating pletilol and emulsifier to 90-100° C. and then mixing with boiling water; the heating temperature is more preferably 92-98° C. °C, most preferably 95-96 °C.

[0030] In the present invention, the pressure of the dynamic...

Embodiment 1

[0037] The mass content of preparation octacosanol is 15% policosanol: take 10kg rice bran wax, add 3 times the volume of absolute ethanol, 7 times the volume of aviation kerosene, and 0.12 times the quality of sodium hydroxide, and heat it to boiling in a water bath. After stirring and refluxing for 4.5 hours, wash with 5 times the volume of hot water for 3 times, remove the lower aqueous phase, wash until the pH value is approximately equal to 7, cool the supernatant overnight, and vacuum filter to obtain a filter cake, which is desolvated , drying, namely dipricotol, wherein the mass content of octacosanol is 15%.

[0038] After mixing 50 g of pliol and 100 g of Tween 60, the obtained mixture was heated to 100° C., and then dissolved in 5 L of boiling water to obtain a proto-emulsion; the proto-emulsion was subjected to dynamic high-pressure micro-fluidization (4 times at a pressure of 200 MPa) , obtaining a nanoemulsion (the mass ratio of the nanoemulsion of 1~10nm account...

Embodiment 2

[0042] The mass content of preparing octacosanol is 50% of the pleicosanol: under the working pressure of 20Pa, kettle temperature of 210°C, and reflux ratio of 1:10, the pleicosanol (containing octacosanol) prepared in Example 1 alkanol 15%) to carry out rectification, collecting the fraction whose top temperature is 220-230° C. is pliol, wherein the mass content of octacosanol is 50%.

[0043] After mixing 40g of pliol and 30g of Tween 60, the obtained mixture was heated to 100°C and dissolved in 2.5L of boiling water to obtain a proto-emulsion; time), obtaining nanoemulsion (the mass ratio of the nanoemulsion of 1~10nm accounting for the nanoemulsion is 3%, and the mass ratio of the nanoemulsion of 10~100nm accounting for the nanoemulsion is 97%);

[0044] While stirring, the nanoemulsion was added dropwise to 130g of sulfobutyl ether-β-cyclodextrin, xanthan gum and galacto-oligosaccharide mixture (sulfobutyl ether-β-cyclodextrin, xanthan gum and low The mass ratio of poly...

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Abstract

The invention relates to a policosanol microcapsule and a preparation method and application thereof, and belongs to the technical field of medicine. The policosanol microcapsule comprises a policosanol inner core and an outer layer shell; the outer layer shell comprises the materials: sulfobutyl ether-beta-cyclodextrin, hydrophilic colloid, oligosaccharide and an emulsifying agent. The prolidinol microcapsule disclosed by the invention has good solubility and good water solubility and dispersibility, and is universal for people to use in actual production and application.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a pliol microcapsule and a preparation method and application thereof. Background technique [0002] Polyol is a naturally occurring higher alcohol, the main component is octacosanol, the appearance is white powder or scaly crystal, soluble in organic solvents, insoluble in water, mainly found in cane wax, rice bran wax, wheat germ oil , beeswax and insect wax and other natural products. A number of studies have shown that pliol has unique physiological functions such as enhancing endurance, anti-fatigue, lowering blood fat, anti-inflammation, and protecting the liver. However, its poor water solubility and low bioavailability restrict its application in health food and medicine. [0003] Aiming at the problem of poor water solubility of pliol, the publication number is CN1316966C using gum arabic, β-hydroxypropyl cyclodextrin and maltose as wall materials to prepare pliol, al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/045A61K47/69A61P39/00A61P3/06A61P29/00A61P1/16A23L33/10A23L33/125A23P10/30
CPCA61K9/5036A61K31/045A61P39/00A61P3/06A61P29/00A61P1/16A23L33/10A23L33/125A23P10/30A23V2002/00A23V2200/30A23V2200/3262A23V2200/32A23V2250/5112
Inventor 涂越刘建平欧阳克氙郭雄昌蔡力创蒋亮刘会平
Owner INST OF BIOLOGICAL RESOURCES JIANGXI ACAD OF SCI
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