Antibacterial hydrogel with photo-thermal performance as well as preparation method and application of antibacterial hydrogel

A hydrogel and performance technology, applied in the field of antibacterial hydrogel and its preparation, can solve the problems of losing the original efficacy, effectively deal with the wound pathological environment, etc., achieve the improvement of the bactericidal effect, and be suitable for large-scale popularization and preparation. simple craftsmanship
CN113018507AActive Publication Date: 2021-06-25CHANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
CHANGZHOU UNIV
Publication Date
2021-06-25

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Abstract

The invention belongs to the field of biological materials, and particularly relates to antibacterial hydrogel with photo-thermal performance and a preparation method and application thereof. A short-sequence antibacterial peptide (AMP) is connected with polypeptide hydrogel RADA16 through a glycine (G) joint, and the antibacterial hydrogel with inherent antibacterial activity is obtained. Then, a photo-thermal agent, namely copper sulfide nanodots (CuS NDs), is wrapped in the hydrogel, and is rapidly heated through irradiation of near-infrared light, so that a synergistic sterilization effect is generated with the antibacterial hydrogel. The antibacterial hydrogel has good biocompatibility, can continuously act on the surface of a wound, and can achieve the effects of ventilating, moisturizing and sucking out tissue exudate while effectively removing pathogenic bacteria, and meanwhile, the biodegradability of the antibacterial hydrogel further avoids secondary damage to new tissues during stripping. The antibacterial hydrogel is convenient to synthesize, high in safety, excellent in antibacterial performance and capable of effectively improving the healing quality of bacterial infected wounds.
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Description

technical field

[0001] The invention belongs to the technical field of biomaterials, and in particular relates to an antibacterial hydrogel with photothermal properties and a preparation method and application thereof. Background technique

[0002] As the largest organ in the human body, the skin is extremely vulnerable to damage from burns or trauma. Wound healing is a complex and ordered biological process involving multiple stages (ie, hemostasis, inflammation, proliferation, and remodeling). Bacterial infection is one of the serious problems in the wound healing process, hindering the healing process and causing other serious infection-related syndromes.

[0003] Hydrogels are three-dimensional (3D) porous, soft, viscoelastic materials that, as wound dressings, can maintain a moist environment, provide non-adhesive coverage of sensitive underlying tissues, and reduce pain with excellent compliance. Considering the bacterial-induced infection, a series of antibacterial ...

Claims

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