Antibacterial hydrogel with photo-thermal performance as well as preparation method and application of antibacterial hydrogel

A hydrogel and performance technology, applied in the field of antibacterial hydrogel and its preparation, can solve the problems of losing the original efficacy, effectively deal with the wound pathological environment, etc., achieve the improvement of the bactericidal effect, and be suitable for large-scale popularization and preparation. simple craftsmanship

Active Publication Date: 2021-06-25
CHANGZHOU UNIV
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  • Claims
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Problems solved by technology

However, with the emergence of drug-resistant bacteria, traditional antibiotics have gradually lost their original efficacy and can no longer effectively deal with complex and changeable wound pathological environments

Method used

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  • Antibacterial hydrogel with photo-thermal performance as well as preparation method and application of antibacterial hydrogel
  • Antibacterial hydrogel with photo-thermal performance as well as preparation method and application of antibacterial hydrogel
  • Antibacterial hydrogel with photo-thermal performance as well as preparation method and application of antibacterial hydrogel

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Embodiment 1

[0045] 1. Synthesis of Antibacterial Peptide Hydrogels

[0046] The antibacterial polypeptide hydrogel sequence is synthesized by Fmoc solid-phase synthesis method using chemically modified α-amino acid as raw material and ChemMatrix resin as carrier. Specifically: take by weighing 5 times the molar equivalents of the resin, amino acid, condensing agent HBTU, HOBt and dissolve them in an appropriate amount of DMF, add DIEA to crosslink the resin for 30 minutes after fully dissolving; =1:4) Reaction for 30 minutes to remove the Fmoc protecting group. Each step uses ninhydrin solution for color inspection, and repeats the steps until the target peptide chain is synthesized.

[0047] Taking 200mg of resin as an example, the volume of DMF is 4mL, and the volume of DIEA is 400μL.

[0048] The target peptide chain uses a cleavage solution (volume ratio, TFA:EDT:TIS:H 2 O=94:2.5:1:2.5) was separated from the resin, precipitated with glacial ether and dissolved in ultrapure water, ...

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Abstract

The invention belongs to the field of biological materials, and particularly relates to antibacterial hydrogel with photo-thermal performance and a preparation method and application thereof. A short-sequence antibacterial peptide (AMP) is connected with polypeptide hydrogel RADA16 through a glycine (G) joint, and the antibacterial hydrogel with inherent antibacterial activity is obtained. Then, a photo-thermal agent, namely copper sulfide nanodots (CuS NDs), is wrapped in the hydrogel, and is rapidly heated through irradiation of near-infrared light, so that a synergistic sterilization effect is generated with the antibacterial hydrogel. The antibacterial hydrogel has good biocompatibility, can continuously act on the surface of a wound, and can achieve the effects of ventilating, moisturizing and sucking out tissue exudate while effectively removing pathogenic bacteria, and meanwhile, the biodegradability of the antibacterial hydrogel further avoids secondary damage to new tissues during stripping. The antibacterial hydrogel is convenient to synthesize, high in safety, excellent in antibacterial performance and capable of effectively improving the healing quality of bacterial infected wounds.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to an antibacterial hydrogel with photothermal properties and a preparation method and application thereof. Background technique [0002] As the largest organ in the human body, the skin is extremely vulnerable to damage from burns or trauma. Wound healing is a complex and ordered biological process involving multiple stages (ie, hemostasis, inflammation, proliferation, and remodeling). Bacterial infection is one of the serious problems in the wound healing process, hindering the healing process and causing other serious infection-related syndromes. [0003] Hydrogels are three-dimensional (3D) porous, soft, viscoelastic materials that, as wound dressings, can maintain a moist environment, provide non-adhesive coverage of sensitive underlying tissues, and reduce pain with excellent compliance. Considering the bacterial-induced infection, a series of antibacterial ...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61K41/00A61K38/10A61K9/06A61P31/04A61P17/02
CPCA61L26/008A61L26/0066A61L26/0047A61L26/0004A61L26/009A61K41/0052A61K38/10A61K9/06A61P31/04A61P17/02A61L2300/404A61L2300/102A61L2300/252A61L2300/412A61K2300/00Y02A50/30
Inventor 王建浩王璇李梦金韩倩倩陶思曼崔朋飞邱琳周舒文王程雒莉王菲
Owner CHANGZHOU UNIV
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