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Targeted ultrasonic contrast agent for enhancing ultrasonic diagnosis of carotid arteriosclerosis and preparation method thereof

A technology for ultrasound contrast agents and arteriosclerosis, which is applied in the direction of echo/ultrasound imaging agents, preparations for in vivo tests, and pharmaceutical formulations. It can solve the problems of complex preparation methods, high requirements for storage and transportation conditions, and high use costs. The method is simple and easy, the clinical dosage is reduced, and the cost is low

Active Publication Date: 2021-06-29
HEILONGJIANG UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to further enhance the targeted imaging enhancement effect of ultrasound contrast agents, there are more and more studies on targeted ultrasound contrast agents. The existing targeted ultrasound contrast agents often use antigen-antibody, biotin-anti-biotin and other means to achieve target imaging. It has disadvantages such as complex preparation methods, high requirements for storage and transportation conditions, and high cost of use, which limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: A targeted ultrasound contrast agent for enhancing ultrasound diagnosis of carotid atherosclerosis

[0024] 7 parts of hyaluronic acid, 93 parts of soybean lecithin, 40% tert-butanol solution, appropriate amount of perfluoropropane, prepared according to the following steps:

[0025] (1) Add soybean lecithin containing hyaluronic acid to a mixed solution of 8 times the weight of tert-butanol and water, homogenize at 30°C for 4 minutes under a pressure of 100MPa, and then filter and sterilize through a 220nm filter membrane to obtain an emulsion;

[0026] (2) Divide the emulsion obtained in step (1) into vials and vacuum freeze-dry to obtain freeze-dried powder, then slowly fill in perfluoropropane to 55KPa in a vacuum state, and then slowly fill in the mixed gas of perfluoropropane and nitrogen to 1 standard atmospheric pressure, then use a rubber stopper to seal the vial, and the volume ratio of perfluoropropane in the mixed gas is 50%;

[0027] (3) Use the...

Embodiment 2

[0028] Example 2: A targeted ultrasound contrast agent for enhancing ultrasound diagnosis of carotid atherosclerosis

[0029] 3 parts of hyaluronic acid, 4 parts of mannuronic acid, 93 parts of soybean lecithin, 40% tert-butanol solution, appropriate amount of perfluoropropane, prepared according to the following steps:

[0030] (1) Add soybean lecithin containing hyaluronic acid and mannuronic acid to a mixed solution of 8 times the weight of tert-butanol and water, homogenize at 30°C and 100MPa pressure for 4 minutes, then filter and sterilize through a 220nm filter membrane, get lotion;

[0031] (2) Divide the emulsion obtained in step (1) into vials and vacuum freeze-dry to obtain freeze-dried powder, then slowly fill in perfluoropropane to 55KPa in a vacuum state, and then slowly fill in the mixed gas of perfluoropropane and nitrogen to 1 atmospheric pressure, then use a rubber stopper to seal the vial, and the volume ratio of perfluoropropane in the mixed gas is 50%;

...

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PUM

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Abstract

The invention relates to a targeted ultrasonic contrast agent for enhancing ultrasonic diagnosis of carotid arteriosclerosis and a preparation method thereof. The targeted ultrasonic contrast agent for enhancing ultrasonic diagnosis of carotid arteriosclerosis is prepared from phospholipid containing hyaluronic acid and optional mannose and derivatives thereof, and biological inert gas, the carotid arteriosclerosis targeting property of the ultrasonic contrast agent is realized at low cost, and the ultrasonic imaging effect of carotid arteriosclerosis is enhanced.

Description

technical field [0001] The invention belongs to the field of diagnostic reagents, and in particular relates to a targeted ultrasound contrast agent for enhancing ultrasound diagnosis of carotid atherosclerosis and a preparation method thereof. Background technique [0002] Atherosclerosis (Artherosclerosis, AS) refers to the deposition of blood components such as lipids in the arterial intima, the proliferation of smooth muscle cells and the increase of collagen fibers, forming atherosclerotic fat-containing necrotic lesions and sclerosis of the vessel wall. Atherosclerosis is the result of the joint action of multiple factors, and its pathogenesis is complex. Among them, lipid metabolism disorder is the basis of atherosclerosis. It is characterized by the involvement of arterial lesions starting from the intima. Sugar accumulation, hemorrhage and thrombosis, further fibrous tissue hyperplasia and calcium deposition, and gradual degeneration and calcification of the arterial...

Claims

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Application Information

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IPC IPC(8): A61K49/22
CPCA61K49/221A61K49/223
Inventor 石光煜李丹姜丽丽孟扬张倩尹磊焦洋张雪娇苏德春王丽颖
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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