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Thuja leaf gel absorbent for treating alopecia areata, preparation method thereof, and an external patch for treating alopecia areata

A technology of arborvitae leaves and absorbents, applied in the field of external patches for the treatment of alopecia areata, can solve the problems of serious side effects and low bioavailability, and achieve the effects of reducing side effects, good curative effect, and improving bioavailability

Active Publication Date: 2022-04-29
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the disadvantages of low bioavailability and serious side effects of oral and external preparations in the prior art in the treatment of alopecia areata, the present invention provides a non-irritating and effectively absorbed arborvitae leaf gel absorbent, which can target The absorption characteristics of the skin in the area of ​​alopecia areata fully and slowly release the active ingredients to achieve the purpose of treating alopecia areata

Method used

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  • Thuja leaf gel absorbent for treating alopecia areata, preparation method thereof, and an external patch for treating alopecia areata
  • Thuja leaf gel absorbent for treating alopecia areata, preparation method thereof, and an external patch for treating alopecia areata
  • Thuja leaf gel absorbent for treating alopecia areata, preparation method thereof, and an external patch for treating alopecia areata

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 is used for the preparation of the orientalis leaf gel absorbent for the treatment of alopecia areata

[0047] (1) Dissolve 10mg of Arborvitae leaf extract and 100mg of glyceryl monostearate in 4mL of absolute ethanol, and prepare an organic phase in a water bath at 70°C; dissolve 100mg of poloxamer-188 and 100mg of lecithin in 20mL Prepare the water phase in deionized water in a water bath at 70°C. Quickly inject the organic phase into the water phase, keep the water bath temperature at 70°C, 1000rpm, stir magnetically for 50min, remove the organic solvent to form a translucent nanoemulsion, then pour the prepared nanoemulsion into 10mL of water at 4°C, and stir magnetically for 2h , to prepare nanoparticle dispersion of orientalis leaf extract.

[0048] (2) After adding 1 g of mannitol to the nanoparticle dispersion of the cypress leaf extract as a freeze-drying protective agent, put it in a -80°C refrigerator for pre-freezing for 18 hours, and place it ...

Embodiment 2

[0051] Example 2 Utilizing different batches of orientalis leaf extracts to prepare the arborvitae leaf extract gel absorbent

[0052] The content of different batches of oriental cypress leaf extracts is slightly different. Using different batches of oriental cypress leaf extracts to prepare arborvitae leaf extract gel preparations can study the repeatability of its preparation process and explore its release in vitro . The preparation steps are specifically the same as in Example 1, and the ingredients are as shown in Table 1:

[0053] Table 1

[0054]

[0055] The particle size of the nanoparticles of the cypress leaf extract was 240±36nm, the encapsulation efficiency of the three batches were 73.6%, 72.5%, and 73.24%, respectively, and the phase transition temperature of the temperature-sensitive gel was 33±2°C.

[0056] The release amount of three batches of orientalis leaf extract gel absorbent in different time periods was measured by the following method:

[0057...

Embodiment 3

[0061] The screening of embodiment 3 lipid material

[0062] Weigh 100 mg each of glyceryl monostearate, stearic acid, beeswax, myristic acid, and polyoxyethylene monostearate, and put them in a 10 mL beaker. quality melted. In each lipid, slowly add the powder of oriental thuja leaf extract until reaching saturation, and calculate the solubility of the orientalis leaf extract in different lipids.

[0063] like figure 2 As shown, in 100mg of lipid material, glyceryl monostearate dissolves 10.38mg of Arborvitae leaf extract, which is higher than the other four lipid materials. The solubility of drugs in lipids determines the encapsulation efficiency of drugs, so glycerol monostearate was selected as the material for preparing solid lipid nanoparticles of orientalis leaf extract.

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Abstract

The invention discloses a cypress leaf gel absorbent for treating alopecia areata, a preparation method thereof and an external patch for treating alopecia areata, belonging to the technical field of traditional Chinese medicine preparations. The arborvitae leaf gel absorbent is composed of oriental cypress leaf extract nanoparticles and gel at a mass ratio of 1:1 to 100, wherein the arborvitae leaf extract nanoparticles are a mixture of arborvitae leaf extract and medicinal polymer lipids The nanoparticle dispersion was prepared from the raw material, and then freeze-dried; the temperature-sensitive hydrogel was composed of the following components according to the mass fraction: sodium carboxymethylcellulose 5-10%, poloxamer-188 1-5%, Poloxamer-407 5-10%, monolauryl phosphate 3-10%, glycerin 1-10%, the balance water. The arborvitae leaf gel absorbent of the present invention has the advantages of high safety, good curative effect, low side effects and significant promotion of hair growth, can significantly improve bioavailability, increase patient compliance, reduce patient side effects, and thus improve therapeutic effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a cypress leaf gel absorbent for treating alopecia areata, a preparation method thereof, and an external patch for treating alopecia areata. Background technique [0002] With the increasing pace of life in modern society, the phenomenon of sudden non-scarring hair loss is increasing due to local blood circulation disorder caused by excessive brain use, excessive mental stress, and scalp tension. At present, the external preparations of Western medicine for alopecia areata mainly include minoxidil lotion. The principle of minoxidil for hair loss is that it can stimulate the expression of vascular endothelial growth factor in dermal papilla cells, dilate blood vessels in the scalp, improve microcirculation, and promote hair growth. . However, it has the disadvantages of short residence time of active ingredients, obvious dose dependen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/14A61K47/14A61K47/10A61K47/24A61K47/38A61K9/70A61P17/14
CPCA61K36/14A61K9/06A61K9/0014A61K47/14A61K47/10A61K47/24A61K47/38A61K9/7023A61P17/14
Inventor 金青李微微刘兴华郝小惠陈永根赵文英谭心舜
Owner QINGDAO UNIV OF SCI & TECH
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