High-elastic antibacterial eco-friendly dressing and preparation method thereof

A friendly and ecological technology, applied in the fields of filament/thread forming, medical science, non-woven fabrics, etc., can solve the problems of large expansion and contraction, the dressing can not fit the joint skin well, environmental hazards, etc., and is conducive to stability sexual effect

Active Publication Date: 2021-07-09
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large displacement and stretching range of the skin at the joint, general dressings cannot fit the joint skin well
[0003] In addition, the commonly used high-efficiency antibacterial a

Method used

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  • High-elastic antibacterial eco-friendly dressing and preparation method thereof
  • High-elastic antibacterial eco-friendly dressing and preparation method thereof
  • High-elastic antibacterial eco-friendly dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A high-elastic antibacterial eco-friendly dressing and a preparation method thereof, comprising the steps of:

[0028] 1. Wash and dry 5g of human nails, crush them, soak them together with 0.35g of sodium sulfide in 20ml of 40% liquid caustic soda solution at 90°C for 16 hours, filter them, and obtain the retentate by ultrafiltration with a molecular weight cut-off of 5000, spray Dried human nail keratin;

[0029] 2. Add 1g of human nail keratin, 12g of zein, 4g of polypyrrole with a conductivity of 30S / cm and 4g of thermoplastic polyurethane elastomer with a glass transition temperature of 110°C to 100ml of dimethyl ethyl alcohol prepared in step 1. In the amide, after fully stirring, the slurry is spray-dried to obtain the precursor powder;

[0030] 3. Heat and melt the precursor powder prepared in step 2 under a nitrogen atmosphere, and perform melt electrospinning at a temperature of 190°C, a voltage of 18kv, a distance of 18cm, and an injection rate of 1.5ml / h to...

Embodiment 2

[0033] A high-elastic antibacterial eco-friendly dressing and a preparation method thereof, comprising the steps of:

[0034] 1. Wash and dry 5g of human nails, crush them, soak them together with 0.3g of sodium sulfide in 15ml of 40% liquid caustic soda solution at 80°C for 12h, filter them, and obtain the retentate by ultrafiltration with a molecular weight cut-off of 5000, and spray Dried human nail keratin;

[0035] 2. Add 0.5g of human nail keratin prepared in step 1, 10g of zein, 3g of polypyrrole with a conductivity of 10S / cm and 2g of thermoplastic polyurethane elastomer with a glass transition temperature of 100°C to 100ml of dimethyl In acetamide, after fully stirring, the slurry is spray-dried to obtain a precursor powder;

[0036] 3. Heat and melt the precursor powder prepared in step 2 under a nitrogen atmosphere, and perform melt electrospinning at a temperature of 180°C, a voltage of 15kv, a distance of 15cm, and an injection rate of 1ml / h to obtain fibers mem...

Embodiment 3

[0039] A high-elastic antibacterial eco-friendly dressing and a preparation method thereof, comprising the steps of:

[0040] 1. Wash and dry 5g of human nails, crush them, soak them together with 0.4g of sodium sulfide in 25ml of 40% liquid caustic soda solution at 100°C for 18 hours, filter them, and obtain the retentate by ultrafiltration with a molecular weight cut-off of 5000, spray Dried human nail keratin;

[0041] 2. Add 2g of human nail keratin, 15g of zein, 5g of polypyrrole with a conductivity of 50S / cm and 5g of thermoplastic polyurethane elastomer with a glass transition temperature of 125°C to 100ml of dimethyl ethyl alcohol prepared in step 1. In the amide, after fully stirring, the slurry is spray-dried to obtain the precursor powder;

[0042] 3. Heat and melt the precursor powder prepared in step 2 under a nitrogen atmosphere, and conduct melt electrospinning at a temperature of 200°C, a voltage of 20kv, a distance of 20cm, and an injection rate of 2ml / h to o...

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Abstract

The invention belongs to the field of biomedical materials, and relates to a high-elastic antibacterial eco-friendly dressing and a preparation method thereof. The preparation method comprises the following steps of: dissolving keratin, zein, polypyrrole and polyurethane in dimethylacetamide; carrying out spray drying; performing heating and melting in a nitrogen atmosphere; carrying out melting electrostatic spinning; carrying out soaking treatment with tris (2-carboxyethyl) phosphine; carrying out treatment with a silver cyanate solution; and carrying out low-temperature plasma treatment to prepare the high-elastic antibacterial eco-friendly dressing. The prepared dressing is high in elasticity, good in antibacterial effect, low in silver ion release and environmentally friendly.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a high-elastic antibacterial eco-friendly dressing and a preparation method thereof. Background technique [0002] Human joints are vulnerable to physical and chemical damage during exercise or labor, resulting in skin damage. Wound infection caused by unclean local cleaning of damaged skin will cause delayed healing and enlargement of the wound in mild cases, and severe infection and sepsis in severe cases. However, due to the large displacement and stretching range of the skin at the joint, general dressings cannot fit the joint skin well. [0003] In addition, the commonly used high-efficiency antibacterial agent is silver preparation, but silver is highly toxic to microorganisms and aquatic organisms in the ecological environment, which can greatly affect the ecological balance and cause environmental hazards. Contents of the invention [0004] In view of t...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/46A61L15/32A61L15/26A61L15/42D01D5/00D04H1/728
CPCA61L15/18A61L15/46A61L15/32A61L15/26A61L15/42D01D5/0015D04H1/728A61L2300/104A61L2300/404C08L89/00C08L79/04
Inventor 葛彦徐飞妮傅海洪汤佳鹏刘莺
Owner NANTONG UNIVERSITY
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