Check patentability & draft patents in minutes with Patsnap Eureka AI!

Preparation method of 3D printed bacteriostatic cavity repair stent

A 3D printing and cavity technology, applied in prosthetics, coatings, medical science, etc., can solve the problems of repairing scaffolds with single function, lack of antibacterial properties, and susceptibility to bacterial infection, etc., and achieve good cell compatibility and good Bioabsorption performance, antibacterial and antibacterial performance, and long-term antibacterial effect

Inactive Publication Date: 2021-07-16
贺义凡
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 3D printed materials also need to meet certain mechanical properties in order to have good formability; in addition, the current repair scaffolds prepared by 3D printing have relatively single functions and do not have antibacterial properties, which often lead to their susceptibility to bacteria in applications. Infection leads to a series of inflammation and complications

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method for 3D printing antibacterial cavity repair bracket, comprising the following steps:

[0027] (1) Obtain biomorphic data of the cavity to be repaired, establish three-dimensional data, and obtain a 3D printing model of the cavity through computer modeling;

[0028] (2) Put the drug-loaded polylactic acid-glycolic acid copolymer, polyε-caprolactone and modified sodium alginate mixed hydrogel into the 3D printer, and prepare the hydrogel cavity scaffold by photocuring 3D printing; , drug-loaded polylactic acid-glycolic acid copolymer, polyε-caprolactone and modified sodium alginate are mixed according to the mass ratio of 5:3:1;

[0029] (3) The surface of the hydrogel cavity scaffold described in step (2) is modified with polydopamine to obtain an antibacterial cavity repair scaffold.

[0030] Wherein, the preparation method of described modified sodium alginate comprises the steps:

[0031] (1) Take sodium alginate and prepare it as an aqueous sol...

Embodiment 2

[0035] A preparation method for 3D printing antibacterial cavity repair bracket, comprising the following steps:

[0036] (1) Obtain biomorphic data of the cavity to be repaired, establish three-dimensional data, and obtain a 3D printing model of the cavity through computer modeling;

[0037] (2) Mix vancomycin-loaded polylactic acid-glycolic acid copolymer, polyε-caprolactone, and modified sodium alginate at a mass ratio of 9:7:2, prepare a hydrogel, and put it into the 3D A printer that prepares a hydrogel cavity bracket by photocuring 3D printing;

[0038] (3) The surface of the hydrogel cavity scaffold described in step (2) is modified with polydopamine to obtain an antibacterial cavity repair scaffold.

[0039] Wherein, the preparation method of described modified sodium alginate comprises the steps:

[0040] (1) Take sodium alginate and prepare it as an aqueous solution of sodium alginate with a mass concentration of 2%;

[0041] (2) introducing oxygen into the sodium...

Embodiment 3

[0044] A preparation method for 3D printing antibacterial cavity repair bracket, comprising the following steps:

[0045] (1) Obtain biomorphic data of the cavity to be repaired, establish three-dimensional data, and obtain a 3D printing model of the cavity through computer modeling;

[0046] (2) Mix antibiotic-loaded polylactic acid-glycolic acid copolymer, polyε-caprolactone, and modified sodium alginate at a mass ratio of 7:5:1.5, prepare a hydrogel, and put it into a 3D printer. Preparation of hydrogel lumen scaffolds by photocuring 3D printing;

[0047] (3) modifying the surface of the hydrogel cavity scaffold described in step (2) with polydopamine to obtain the antibacterial cavity repair scaffold;

[0048] Wherein, the preparation method of described modified sodium alginate comprises the steps:

[0049] (1) Take sodium alginate and configure it as an aqueous solution of sodium alginate with a mass concentration of 1.5%;

[0050] (2) Oxygen is introduced into the so...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of human body stents, and particularly relates to a preparation method of a 3D printed bacteriostatic cavity repair stent, a polylactic acid-glycollic acid copolymer, poly epsilon-caprolactone and a modified sodium alginate mixed hydrogel are used as a raw material, a polydopamine coating is loaded on the surface of the prepared hydrogel cavity stent, and is applied in cavity repair; the 3D printed bacteriostatic cavity repair stent has good biological absorption performance and antibacterial and bacteriostatic performance, can slowly release active drugs, has long effective bacteriostatic time and good cytocompatibility, and has osteogenesis promoting performance.

Description

technical field [0001] The invention belongs to the technical field of human body stents, specifically relates to the technical field of human body absorbable biological stents, and in particular to a preparation method of a 3D printed antibacterial cavity repairing stent. Background technique [0002] Tissue engineering scaffold materials can be combined with tissue living cells and can be implanted into different tissues of the organism, and can replace the functional materials of the tissues according to the specific materials. In order to proliferate and differentiate seed cells, it is necessary to provide a cell scaffold composed of biomaterials, which is equivalent to artificial extracellular matrix. Tissue engineering scaffold materials include: tissue scaffold materials for bone, cartilage, blood vessels, nerves, skin and artificial organs, such as liver, spleen, kidney, bladder, etc. Hydrogel scaffolds can provide a microenvironment closer to the natural cartilage ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/54A61L27/18A61L27/20A61L27/34C08J7/04C09D179/04C08J3/075C08L67/04C08L5/04B33Y70/00
CPCA61L27/18A61L27/20A61L27/34A61L27/54A61L27/58A61L2300/406A61L2300/602A61L2430/34B33Y70/00C08J3/075C08J2367/04C08J2405/04C08J2467/04C08J2479/04C09D179/04C08L67/04C08L79/04C08L5/04
Inventor 贺义凡
Owner 贺义凡
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com