A kind of synthetic method of cytochalasin compound flavipesine A

A technology for the synthesis of cytochalasin and its synthesis method, which is applied in the field of synthesis of the cytochalasin compound flavipesineA, which can solve the problems of high cost, long cycle, and expensive price, and achieve the effects of low cost, short production cycle, and high production efficiency
CN113135931BActive Publication Date: 2022-05-31NANKAI UNIV
1 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2022-05-31

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a synthesis method of flavipesine A, a cytochalasin compound. The structural formula of the compound is: the synthesis method comprises: 1) dissolving compound B in tetrahydrofuran, adding a reducing agent at room temperature, and reacting at 40°C to obtain Intermediate C; 2) At room temperature, add the reaction reagent to the THF solution of Intermediate C to obtain Compound A. The reagents used in the synthesis process provided by the present invention can be purchased commercially at low prices, and this reaction strategy is also applicable to the synthesis of other types of cytochalasin-like intermediate product derivatives, so as to study the structure modification and structure-activity relationship of this type of alkaloids , New drug development and mass production lay the foundation.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of chemical synthesis, in particular to a method for synthesizing a cytochalasin compound flavipesine A. Background technique

[0002] Natural products with complex and diverse structures have always been an important source of small molecule drug discovery. Although natural products have rich and diverse structures, their natural sources are often very limited, and it is difficult to conduct in-depth research on their chemical properties and biological activities. Therefore, how to be concise and efficient. , Obtaining a large number of natural products with specific structures and their analogs has become an important research content of natural product chemical synthesis, biosynthesis and organic synthesis methodology.

[0003] Cytochalasan is a kind of fungal polyamino acid hybrid secondary metabolite with significant biological functions. So far, more than 400 different compounds in this family have be...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More