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Poly(4-methyl-1-pentene) hollow fiber membrane applied to ECMO, and preparation method thereof

A fiber membrane and pentene technology, which is applied in the field of poly-4-methyl-1-pentene hollow fiber membrane and its preparation, can solve the problems of complex production process, difficult regulation of pore size, and many control conditions, etc. The effect of good continuity, uniform distribution of surface pore structure, and easy control

Pending Publication Date: 2021-07-23
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method avoids the addition of a large amount of solvent, there are many conditions to be controlled, the production process is relatively complicated, the pore size is difficult to control, and the processing temperature is high.
[0006] At present, there is still a lack of preparation technology for preparing poly-4-methyl-1-pentene hollow fiber membranes with regular structure by melt extrusion of poly-4-methyl-1-pentene applied in ECMO

Method used

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  • Poly(4-methyl-1-pentene) hollow fiber membrane applied to ECMO, and preparation method thereof
  • Poly(4-methyl-1-pentene) hollow fiber membrane applied to ECMO, and preparation method thereof
  • Poly(4-methyl-1-pentene) hollow fiber membrane applied to ECMO, and preparation method thereof

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preparation example Construction

[0057] In the preparation method of the present invention, preferably adopt binary diluent, wherein a kind of diluent is better with the compatibility of poly-4-methyl-1-pentene, such as dioctyl phthalate; And another A diluent has poor compatibility with poly-4-methyl-1-pentene, for example: dibutyl sebacate, triethyl phosphate, triethyl citrate, etc. The one-component diluent and PMP have good solubility, high interaction force, narrow phase separation area, and easy S-L phase separation to form lace-like or crystalline structures. If the second diluent with poor compatibility is used, the cloud point curve will move up, the phase separation region will become wider, and L-L phase separation will easily occur, forming a honeycomb or continuous pore structure, and the permeation flux will increase.

[0058] The purpose of the additive can enhance the overall viscosity of the casting solution, and the uniformity of the hollow fiber obtained by the casting solution system throu...

Embodiment 1

[0087] For the preparation of polymer base film by thermal phase separation method, the content and treatment method of each material in the film forming system are as follows, the polymer is poly-4-methyl-1-pentene (PMP), which is produced by Mitsui Chemicals, Japan, and the commodity type It is TPX, the mass content is 50%, and the thinner adopts dioctyl phthalate with good compatibility with TPX as the single diluent, and the mass content is 40%, and the porogen PEG-400 is used as the additive, and the mass content is 10% %.

[0088] Put the mixed raw materials into a twin-screw extruder and extrude at a temperature of 250° C.; the residence time of the entire extrusion process is 5 minutes, and the pressure is 5 MPa. Extruded through the spinneret, after passing through the 10cm air section, the temperature is lowered in the quenching bath to cause phase separation, and after cooling, it is rapidly solidified to form a film, and then stretched by the godet wheel and then e...

Embodiment 2

[0091] For the preparation of polymer base film by thermal phase separation method, the content and treatment method of each material in the film forming system are as follows, the polymer is poly-4-methyl-1-pentene (PMP), which is produced by Mitsui Chemicals, Japan, and the commodity type It is TPX, the mass content is 50%. The diluent adopts dioctyl phthalate with good compatibility with TPX and dibutyl phthalate with poor compatibility with TPX as binary diluent, and phthalic acid The mass content of dioctyl ester is 15%, the mass content of dibutyl phthalate is 25%, and the porogen PEG-400 is used as an additive, and the mass fraction is 10%.

[0092] Put the mixed raw materials into a twin-screw extruder and extrude at a temperature of 250° C.; the residence time of the entire extrusion process is 5 minutes, and the pressure is 5 MPa. Extruded through the spinneret, after passing through the 10cm air section, the temperature is lowered in the quenching bath to cause phas...

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Abstract

The invention relates to a preparation method of a hollow fiber membrane, and concretely relates to a poly(4-methyl-1-pentene) hollow fiber membrane applied to ECMO, and a preparation method thereof. According to the method for preparing the poly(4-methyl-1-pentene) porous membrane by adopting the melt extrusion method, the poly(4-methyl-1-pentene) hollow fiber membrane with different membrane pore forms is prepared from poly(4-methyl-1-pentene) and different types of diluents in the production process of the method. According to the principle of film forming, after poly(4-methyl-1-pentene) powder and a diluent are mixed, the mixture is subjected to double-screw melting and then stretched, extruded and molded through a spinning nozzle, the poly(4-methyl-1-pentene) hollow fiber membrane is prepared through two-step cold and hot stretching, rubber material coating is conducted through a deposition tank, a compact layer is formed on the surface of the hollow fiber film, and the diluent is extracted to generate different membrane pore forms and porous structures, so that the poly(4-methyl-1-pentene) composite hollow fiber membrane with certain pore size distribution, good microporous structure and anti-leakage function is obtained.

Description

technical field [0001] The invention relates to a preparation method of a hollow fiber membrane, in particular to a poly-4-methyl-1-pentene hollow fiber membrane applied to ECMO and a preparation method thereof. Background technique [0002] Extracorporeal Membrane Oxygenation (ECMO), which is a combination of artificial lung and artificial heart, is a medical emergency technical equipment, the core part is the membrane lung and blood pump, which play the role of artificial lung and artificial heart respectively , can provide short-term cardiopulmonary support to patients with severe cardiopulmonary failure, and win precious time for critically ill rescue. ECMO support is an adjuvant treatment measure that cannot be replaced by other medical technologies at present, and to a certain extent represents the hospital's rescue level for critically ill patients. According to the MarketsandMarkets research report, Microvat, Medtronic and Rinova (the ECMO brand is Sorin) are the to...

Claims

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Application Information

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IPC IPC(8): B01D67/00B01D69/08B01D71/26A61M1/36
CPCA61M1/3621B01D71/26B01D69/08B01D67/0002B01D67/0027B01D67/0081
Inventor 崔朝亮何金晖何婷周玥汪朝晖汪效祖邢卫红范益群
Owner NANJING UNIV OF TECH
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