Application of non-oral berberine

A berberine, non-oral technology, applied in the field of non-oral berberine or its salts, can solve the problems of poor gastrointestinal absorption, buried pharmacological activity, low bioavailability and the like, and achieves less adverse reactions, good effects, The effect of high safety
CN113171364APending Publication Date: 2021-07-27厦门市健康医疗大数据中心
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
厦门市健康医疗大数据中心
Publication Date
2021-07-27

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Abstract

The invention discloses an application of non-oral berberine. The berberine is used as a main effective component of heat-clearing and detoxifying traditional Chinese medicines such as coptis chinensis and golden cypress, is clinically and widely used for treating gastrointestinal bacterial infection, has main indications of enteritis, dysentery and the like, and is relatively high in safety, few in adverse reaction, low in price and high in acceptability. The invention finds that berberine has a good curative effect on mouse acute pneumonia and lung injury caused by the mouse acute pneumonia in a non-oral administration way, which prompts that berberine is expected to be used for preparing non-oral medicines for preventing and treating lung injury and pneumonia, and can also be used for preparing potential medicines for upper respiratory infection and lung injury caused by the upper respiratory infection. The application is expected to increase the indications of berberine and expand the clinical application range of berberine, has potential application prospects in the fields of traditional Chinese medicine modernization, health, medical treatment and the like, and generates certain social benefits and economic benefits.
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Description

technical field

[0001] The invention belongs to the field of medicine, in particular to the use of berberine, in particular to the use of non-oral berberine or a salt thereof. Background technique

[0002] Berberine is an antibacterial active ingredient extracted from Chinese medicine Coptis chinensis and Cortex Phellodendron by Japanese and German scholars in the early 20th century, and its trade name is berberine. Berberine is an isoquinoline alkaloid with the molecular formula C 20 h 18 NO 4 , molecular weight 336.3, yellow solid, soluble in water, low solubility in organic solvents. The commonly used clinical form is the salt formed by berberine and acid, such as berberine hydrochloride and berberine sulfate. Berberine is a medicinal ingredient derived from plants. It has been used clinically as an antibacterial drug for many years. It has definite curative effect and high safety. Fungi, molds, viruses, protozoa, and nematodes have inhibitory and killing effects, an...

Claims

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