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Magnetocaloric-immune combined medicine and application thereof

A drug and magnetocaloric technology, applied in the field of combined magnetocaloric-immune drugs, can solve the problems of high side effects of the body and the development limitation of immunocombination therapy, and achieve the effect of good thermal effect, inhibition of remote tumor growth, and high-efficiency tumor treatment effect.

Active Publication Date: 2021-07-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most common ones are chemotherapy, radiotherapy or photothermal therapy combined with immunotherapy, but chemotherapy and radiotherapy usually have high side effects on the body, while photothermal therapy can only treat the tissue surface due to poor tissue penetration of light. These factors have limited the development of immunocombination therapies for tumors below a few millimeters

Method used

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  • Magnetocaloric-immune combined medicine and application thereof
  • Magnetocaloric-immune combined medicine and application thereof
  • Magnetocaloric-immune combined medicine and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0058] Embodiment 1 A kind of magnetothermic-immune combination therapy medicine

[0059] (1) A combination of magnetocaloric-immune therapy comprising amphiphilic polyphosphate-modified ferromagnetic nanocrystals (PPE FION ) and amphiphilic polyphosphate modified immune adjuvants (PPE R848 ).

[0060] (2) Amphiphilic polyphosphate modified ferromagnetic nanocrystals (PPE FION ) preparation: the ultrasonic self-assembly method was used to prepare amphiphilic polyphosphate-modified ferromagnetic nanocrystals, specifically as follows: Weigh 20 mg polyethylene glycol-b-poly 2-hexyloxy-2-oxygen-1,3 , 2-dioxaphospholane (PEG-PHEP) (polyethylene glycol-b-poly 2-hexyloxy group-2-oxygen-1,3, the synthetic method of 2-dioxaphospholane References: Junxia, ​​Wang, Yang, et al.NIR-Activated Supersensitive Drug Release Using Nanoparticles with a Flow Core[J].Advanced Functional Materials,2016,26(41):7516-7525), and 1mL ferromagnetic nanocrystals (FION ) solution (2mg / mL, the solvent is...

Embodiment 2

[0066] Embodiment 2 A kind of magnetothermic-immune combination therapy medicine

[0067] (1) A combination of magnetocaloric-immune therapy comprising amphiphilic polyphosphate-modified ferromagnetic nanocrystals (PPE FION ) and amphiphilic polyphosphate modified immune adjuvants (PPE R848 ).

[0068] (2) Amphiphilic polyphosphate modified ferromagnetic nanocrystals (PPE FION ) preparation: the ultrasonic self-assembly method was used to prepare amphiphilic polyphosphate-modified ferromagnetic nanocrystals, as follows: Weigh 10 mg polyethylene glycol-b-poly2-hexyloxy-2-oxygen-1,3 , 2-dioxaphospholane (PEG-PHEP) (polyethylene glycol-b-poly 2-hexyloxy group-2-oxygen-1,3, the synthetic method of 2-dioxaphospholane References: Junxia, ​​Wang, Yang, et al.NIR-Activated Supersensitive Drug Release Using Nanoparticles with a Flow Core[J].Advanced Functional Materials,2016,26(41):7516-7525), and 1mL ferromagnetic nanocrystals (FION ) solution (2mg / mL, the solvent is dimethyl sulf...

Embodiment 3

[0074] Embodiment 3 A kind of magnetothermic-immune combination therapy medicine

[0075] (1) A combination of magnetocaloric-immune therapy comprising amphiphilic polyphosphate-modified ferromagnetic nanocrystals (PPE FION) and amphiphilic polyphosphate modified immune adjuvants (PPE R848 ).

[0076] (2) Amphiphilic polyphosphate modified ferromagnetic nanocrystals (PPE FION ) preparation: the ultrasonic self-assembly method was used to prepare amphiphilic polyphosphate-modified ferromagnetic nanocrystals, as follows: Weigh 30 mg of polyethylene glycol-b-poly 2-hexyloxy-2-oxygen-1,3 , 2-dioxaphospholane (PEG-PHEP) (polyethylene glycol-b-poly 2-hexyloxy group-2-oxygen-1,3, the synthetic method of 2-dioxaphospholane References: Junxia, ​​Wang, Yang, et al.NIR-Activated Supersensitive Drug Release Using Nanoparticles with a Flow Core[J].Advanced Functional Materials,2016,26(41):7516-7525), and 1mL ferromagnetic nanocrystals (FION ) solution (2mg / mL, the solvent is dimethyl s...

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Abstract

The invention belongs to the field of biological medicine, and discloses a magnetocaloric-immune combined medicine and an application thereof. The combined medicine comprises a magnetocaloric agent and an immunologic adjuvant, and the magnetocaloric agent is a ferromagnetic nanocrystal. The combined medicine is directly injected at a focus part, and an alternating magnetic field with specific field intensity is applied, so that tumor cells are killed, generated tumor cell fragments can be used as tumor antigens, and in combination with an immune amplification effect of an immunologic adjuvant, a tumor-like related vaccine effect can be generated, the in-situ tumors can be killed, and far-end tumor growth can be inhibited, and an efficient tumor treatment effect is provided; compared with photo-thermal therapy, the magnetic thermal therapy used in the invention has better tissue penetrability; and compared with traditional commercial Fe3O4 particles, the adopted magnetocaloric agent (ferromagnetic nanocrystals) has a better heat effect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a magnetothermal-immunity combined drug and application thereof. Background technique [0002] With the advancement of science and technology in the fields of biology and medicine, the treatment of tumors by means of immunity (tumor immunotherapy) has attracted more and more attention, and has become a very promising development direction. Tumor immunotherapy is a new type of therapy after surgery, radiation, and chemical drug therapy. Specifically, modern immunotherapy can promote T cell-mediated immunity by modulating immune regulatory signals or activating the immune system against specific tumor-associated antigens. tumor regression. Immunotherapy for the treatment of tumors mainly includes CAR-T therapy, immune checkpoint blockade therapy, cytokine therapy, and cancer vaccine therapy. Despite extensive research during the development phase, treatment failure is often...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K39/39A61K9/00A61K47/52A61K47/59A61K47/64A61P35/00B82Y5/00B82Y20/00B82Y25/00B82Y30/00B82Y40/00
CPCA61K41/0052A61K9/0019A61K9/0009A61K39/39A61P35/00A61K47/52A61K47/59A61K47/645B82Y5/00B82Y20/00B82Y25/00B82Y30/00B82Y40/00A61K2300/00Y02A50/30
Inventor 杨显珠杨冬梅李冬冬
Owner SOUTH CHINA UNIV OF TECH
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